Mechanisms underlying corruption of working memory in Parkinson's disease

Working memory (WM) impairments are reported to occur in patients with Parkinson's disease (PD). However, the mechanisms are unclear. Here, we investigate several putative factors that might drive poor performance, by examining the precision of recall, the order in which items are recalled and whether memories are corrupted by random guessing (attentional lapses). We used two separate tasks that examined the quality of WM recall under different loads and retention periods, as well as a traditional digit span test. Firstly, on a simple measure of WM recall, where patients were asked to reproduce the orientation of a centrally presented arrow, overall recall was not significantly impaired. However, there was some evidence for increased guessing (attentional lapses). On a new analogue version of the Corsi-span task, where participants had to reproduce on a touchscreen the exact spatial pattern of presented stimuli in the order and locations in which they appeared, there was a reduction in the precision of spatial WM at higher loads. This deficit was due to misremembering item order. At the highest load, there was reduced recall precision, whereas increased guessing was only observed at intermediate set sizes. Finally, PD patients had impaired backward, but not forward, digit spans. Overall, these results reveal the task- and load-dependent nature of WM deficits in PD. On simple low-load tasks, attentional lapses predominate, whereas at higher loads, in the spatial domain, the corruption of mnemonic information—both order item and precision—emerge as the main driver of impairment.     

Empirical equivalence and underdetermination

Jarrett Leplin in A Novel Defense of Scientific Realism (1997) argues that if the thesis of empirical equivalence is cogent, then the thesis of underdetermination cannot even get off the ground. Part of Leplin's argument rests on the claim that auxiliary hypotheses can be independently confirmed, thus enabling us to determine the epistemic worth of a theory. This, in turn, helps in determining about what we should be realists. Leplin's claims are demonstrated to be problematic. Leplin wants, inconsistently, to use only those auxiliary hypotheses which dovetail with confirmed theories. Finally, a detail of Leplin's argument is found wanting.     

Assessment of apathy in neurological patients using the Apathy Motivation Index caregiver version

Apathy is a common, disabling neuropsychiatric syndrome that occurs across many brain disorders and may be associated with diminished motivation in behavioural, cognitive, emotional and social domains. Assessment is complicated by the variability of symptoms across apathy domains and self-report from patients, which can be misleading due to their lack of insight. Independent evaluation by clinicians also has limitations though if it has to be performed with limited time. Caregiver reports are a viable alternative, but current assessments for them either do not distinguish between different apathy domains or are interview-based and take long to administer. In this study, we developed a brief caregiver questionnaire version of the recently developed Apathy Motivation Index (AMI), which is a self-report tool. We confirmed three apathy factors in this new caregiver measure (AMI-CG) that were also present in the AMI: Behavioural Activation, Emotional Sensitivity and Social Motivation. Furthermore, we validated the scores against more extensive caregiver interviews using the established Lillle apathy rating scale as well as patient self-reports of apathy, measures of depression, anhedonia, cognition, activities of daily living and caregiver burden across four different neurological conditions: Parkinson's disease, Alzheimer's disease, subjective cognitive impairment and limbic encephalitis. The AMI-CG showed good internal reliability, external validity and diagnostic accuracy. It also uncovered cases of social apathy overlooked by traditional instruments. Crucially, patients who under-rated their apathy compared to informants were more likely to have difficulties performing everyday activities and to be a greater burden to caregivers. The findings provide evidence for a multidimensional conceptualization of apathy and an instrument for efficient detection of apathy based on caregiver reports for use in clinical practice.     

Differences between literates and illiterates on symbolic but not nonsymbolic numerical magnitude processing

The study of numerical magnitude processing provides a unique opportunity to examine interactions between phylogenetically ancient systems of semantic representations and those that are the product of enculturation. While nonsymbolic representations of numerical magnitude are processed similarly by humans and nonhuman animals, symbolic representations of numerical magnitude (e.g., Hindu–Arabic numerals) are culturally invented symbols that are uniquely human. Here, we report a comparison of symbolic and nonsymbolic numerical magnitude processing in two groups of participants who differ substantially in their level of literacy. In this study, level of literacy is used as an index of level of school-based numeracy skill. The data from these groups demonstrate that while the processing of nonsymbolic numerical magnitude (numerical distance effect) is unaffected by an individual’s level of literacy, the processing of Hindu–Arabic numerals differs between literate and illiterate individuals who live in a literature culture and have limited symbolic recognition skills. These findings reveal that nonsymbolic numerical magnitude processing is unaffected by enculturation, while the processing of numerical symbols is modulated by literacy.     

School Counseling in Lebanon: Past,Present, and Future

This article examines the status of school counseling in Lebanon. An overview that points out some weakness in the educational system, such as high dropout and repetition rates, is presented. Calls for counseling have been voiced partly because of the psychological consequences of social change, such as political instability in Lebanon. A sample of school counselors in public and private schools were surveyed. Private school counselors reported fewer stressors and more rewards than did their counterparts in public schools.     

Factors that impact the sociocultural adjustment and well-being of Syrian refugees in Stuttgart – Germany

This study investigated the impact of age, gender, language and acculturation choice on the sociocultural adjustment and well-being of Syrian refugees in Stuttgart, Germany. A total of 214 Syrian refugees participated in this study by filling a demographics questionnaire, the Acculturation Attitudes Scale (AAS-16), the Revised Sociocultural Adjustment Scale (R-SCAS), and the Mental Health Inventory (MHI-18). The results showed that the level of German language acquisition significantly correlated with sociocultural adjustment. No significant correlation was found between age and depression level and no significant difference in depression scores were found as a function of gender. Integration significantly correlated with sociocultural adjustment and mental health. Assimilation correlated significantly with sociocultural adjustment, and separation correlated negatively with mental health.     

Attention,competition, and the parietal lobes: insights from Balint’s syndrome

Simultanagnosia (resulting from occipito-parietal damage) is a profound visual deficit, which impairs the ability to perceive multiple items in a visual display, while preserving the ability to recognise single objects. Here we demonstrate in a patient presenting with Balint’s syndrome that this deficit may result from an extreme form of competition between objects which makes it difficult for attention to be disengaged from an object once it has been selected.     

Be is a raising verb: Psycholinguistic evidence

Psycholinguistic evidence is reported supporting the proposal from theoretical linguistics that the D-structure representation of English copular sentences likeJohn is a fool, The man is happy, etc., is [S [NP e] [vp BE [sc NP XP]]], containing a small clause (SC), rather than [s NP [vp BE XP]], in other words, thatbe is a raising verb. Response times to lexical targets following unaccusative, passive, intransitive, and transitive sentences were compared with response times to lexical targets following corresponding copular sentences. A raising analysis of copular sentences specifies a post-verbal NP-trace of the (raised) NP subject at S-structure. This trace should facilitate the response time to a post-sentence presentation of the head noun of the subject NP, causing copular sentence response times to pattern with the response times for corresponding unaccusatives and passives, which also contain such traces. A traditional nonraising analysis specifies no trace at S-structure. Response times to copular sentences should then pattern with corresponding intransitives and transitives, which also do not contain traces. The observed response-time patterns confirmed the raising analysis.This study was conducted at the National Technical Institute for the Deaf at Rochester Institute of Technology, in the course of an agreement with the U.S. Department of Education.