Understanding the Psychosocial Effects of WES Test Results on Parents of Children with Rare Diseases

The use of whole exome sequencing (WES) for diagnostics of children with rare genetic diseases raises questions about best practices in genetic counselling. While a lot of attention is now given to pre-test counselling procedures for WES, little is known about how parents experience the (positive, negative, or inconclusive) WES results in daily life. To fill this knowledge gap, data were gathered through in-depth interviews with parents of 15 children who underwent WES analysis. WES test results, like results from other genetic tests, evoked relief as well as worries, irrespective of the type of result. Advantages of obtaining a conclusive diagnosis included becoming more accepting towards the situation, being enabled to attune care to the needs of the child, and better coping with feelings of guilt. Disadvantages experienced included a loss of hope for recovery, and a loss by parents of their social network of peers and the effort necessary to re-establish that social network. While parents with conclusive diagnoses were able to re-establish a peer community with the help of social media, parents receiving a possible diagnosis experienced hurdles in seeking peer support, as peers still needed to be identified. These types of psychosocial effects of WES test results for parents are important to take into account for the development of successful genetic counselling strategies.     

Choice in transition: Replication and extension to preschool children in a naturalistic setting

This study replicated previous basic research into the dynamics of choice and extended this analysis to children's behavior in a naturalistic setting. Two preschoolers with disabilities were observed interacting with their teachers at baseline and during an experimental analysis involving four pairs of concurrent variable‐interval schedules of adult attention implemented by an experimenter. Each child was exposed to four experimental phases in which the relative reinforcer rates for on‐ and off‐task behavior were 10:1, 1:1, 1:10, and reversed back to 10:1. The 10:1 phase was designed to mimic the same schedules and types of adult attention observed at baseline. We used the generalized matching equation to model steady‐state behavior at the end of the transition phases and to evaluate changes in sensitivity at various points throughout the phases. Choice in transition was evaluated by plotting log behavior ratios by session, cumulated time on‐ and off‐task and cumulated attention for on‐ and off‐task behavior by session, and interreinforcer behavior ratios following different sequences of the first four reinforcer deliveries. The generalized matching equation accounted for a large proportion of variance in steady‐state responding, sensitivity values increased steadily throughout the phases, patterns of choice in transition were similar to those reported in basic research, and interreinforcer preference generally shifted toward the just‐reinforced alternative. These findings are consistent with previous basic research and support the generality of the dynamics of choice to children's on‐ and off‐task behavior reinforced by adult attention.     

The Productivity of Wh‐ Prompts when Children Testify

Wh‐ prompts (what, how, why, who, when, and where) vary widely in their specificity and accuracy, but differences among them have largely been ignored in research examining the productivity of different question types in child testimony. We examined 120 six‐ to 12‐year‐olds' criminal court testimony in child sexual abuse cases to compare the productivity of various wh‐ prompts. We distinguished among wh‐ prompts, most notably the following: what/how‐happen prompts focusing generally on events, what/how‐dynamic prompts focusing on actions or unfolding processes/events, what/how‐causality prompts focusing on causes and reasons, and what/how‐static prompts focusing on non‐action contextual information regarding location, objects, and time. Consistent with predictions, what/how‐happen prompts were the most productive, and both what/how‐dynamic prompts and wh‐ prompts about causality were more productive than other wh‐ prompts. Prosecutors asked proportionally more what/how‐dynamic prompts and fewer what/how‐static prompts than defense attorneys. Future research and interviewer training may benefit from finer discrimination among wh‐ prompts. Copyright © 2016 John Wiley & Sons, Ltd.     

Train the Trainers: A First Step towards a Science‐Based Cognitive Lie Detection Training Workshop Delivered by a Practitioner

A training workshop utilising recent research in cognitive lie detection was designed and evaluated. A unique future of the training was that a practitioner (retired police detective) instead of scientists (e.g. the training developers) introduced the techniques. To evaluate the training, 27 experienced police detectives each interviewed one mock suspect (a truth teller or liar) before training, and another group of 23 experienced police detectives interviewed one mock suspect (a truth teller or liar) after training. The police detectives were free to interview the mock suspect in any way they felt appropriate, but those who had received training were asked to try to incorporate (some of) the taught techniques in their interviews. The detectives made veracity judgements, and the interviews were transcribed and coded for the amount of detail elicited and the questions asked. Training had a modest effect on the ability to distinguish between truths and lies but resulted in a higher percentage of appropriate questions asked. Trainees did not implement the taught techniques to an equal extent, but when they did, the techniques enhanced the elicitation of information. The training study also revealed challenges, particularly difficulty in implementing the taught techniques into practice and asking the right questions to elicit differences in detail between truth tellers and liars. Copyright © 2015 John Wiley & Sons, Ltd.     

Distinct neuronal patterns of positive and negative moral processing in psychopathy

Psychopathy is a disorder characterized by severe and frequent moral violations in multiple domains of life. Numerous studies have shown psychopathy-related limbic brain abnormalities during moral processing; however, these studies only examined negatively valenced moral stimuli. Here, we aimed to replicate prior psychopathy research on negative moral judgments and to extend this work by examining psychopathy-related abnormalities in the processing of controversial moral stimuli and positive moral processing. Incarcerated adult males (N = 245) completed a functional magnetic resonance imaging protocol on a mobile imaging system stationed at the prison. Psychopathy was assessed using the Hare Psychopathy Checklist–Revised (PCL-R). Participants were then shown words describing three types of moral stimuli: wrong (e.g., stealing), not wrong (e.g., charity), and controversial (e.g., euthanasia). Participants rated each stimulus as either wrong or not wrong. PCL-R total scores were correlated with not wrong behavioral responses to wrong moral stimuli, and were inversely related to hemodynamic activity in the anterior cingulate cortex in the contrast of wrong > not wrong. In the controversial > noncontroversial comparison, psychopathy was inversely associated with activity in the temporal parietal junction and dorsolateral prefrontal cortex. These results indicate that psychopathy-related abnormalities are observed during the processing of complex, negative, and positive moral stimuli.     

The Web-Surf Task: A translational model of human decision-making

Animal models of decision-making are some of the most highly regarded psychological process models; however, there remains a disconnection between how these models are used for pre-clinical applications and the resulting treatment outcomes. This may be due to untested assumptions that different species recruit the same neural or psychological mechanisms. We propose a novel human foraging paradigm (Web-Surf Task) that we translated from a rat foraging paradigm (Restaurant Row) to evaluate cross-species decision-making similarities. We examined behavioral parallels in human and non-human animals using the respective tasks. We also compared two variants of the human task, one using videos and the other using photos as rewards, by correlating revealed and stated preferences. We demonstrate similarities in choice behaviors and decision reaction times in human and rat subjects. Findings also indicate that videos yielded more reliable and valid results. The joint use of the Web-Surf Task and Restaurant Row is therefore a promising approach for functional translational research, aiming to bridge pre-clinical and clinical lines of research using analogous tasks.     

Psychiatry,Cultural Competency,and the Care of Ultra-Orthodox Jews: Achieving Secular and Theocentric Convergence Through Introspection

Several socio-cultural factors complicate mental health care in the ultra-Orthodox Jewish population. These include societal stigma, fear of the influence of secular ideas, the need for rabbinic approval of the method and provider, and the notion that excessive concern with the self is counter-productive to religious growth. Little is known about how the religious beliefs of this population might be employed in therapeutic contexts. One potential point of convergence is the Jewish philosophical tradition of introspection as a means toward personal, interpersonal, and spiritual growth. We reviewed Jewish religious-philosophical writings on introspection from antiquity (the Babylonian Talmud) to the Middle Ages (Duties of the Heart), the eighteenth century (Path of the Just), the early Hasidic movement (the Tanya), and modernity (Alei Shur, Halakhic Man). Analysis of these texts indicates that: (1) introspection can be a religiously acceptable reaction to existential distress; (2) introspection might promote alignment of religious beliefs with emotions, intellect and behavior; (3) some religious philosophers were concerned about the demotivating effects of excessive introspection and self-critique on religious devotion and emotional well-being; (4) certain religious forms of introspection are remarkably analogous to modern methods of psychiatry and psychology, particularly psychodynamic psychotherapy and cognitive-behavioral therapy. We conclude that homology between religious philosophy of emotion and secular methods of psychiatry and psychotherapy may inform the choice and method of mental health care, foster the therapist-patient relationship, and thereby enable therapeutic convergence.     

Defensive Reactions to Masculinity Threat: More Negative Affect Toward Effeminate (but not Masculine) Gay Men

We examined whether, due to men’s desire to reject stereotypically feminine traits in themselves, a masculinity threat would elicit negative affect toward effeminate, but not masculine gay men. Fifty-three male undergraduates from the United States received bogus feedback that they had either a “masculine” or “feminine” personality before rating affect toward two “types” of gay men: effeminate and masculine. Results were consistent with the notion that defensive reactions target groups stereotyped as having the specific traits perceivers wish to deny in themselves: masculinity threat selectively increased negative affect toward effeminate, but not masculine, gay men. Thus, gay men who exhibit feminine traits may be at particular risk from men whose masculinity is threatened.     

The changing nature of motorcycling: Patterns of use and rider characteristics

Notable increases in motorcycling activities since the mid-1990s have been reported in a number of countries worldwide. Governments and enforcement agencies have begun to recognise that not only has this mode of transport been neglected in terms of safety interventions, but also that the reasons behind the increase in popularity are poorly understood. This paper reports the results of a survey distributed to a sample of the UK motorcycling population in order to discover the types of motorcycles they ride and the trips they engage in. From the data, three groups of riders were identified – new, long-term and returning riders. They were additionally stratified by the type of riding they engaged in (leisure or commuting). The results indicated that long-term and returning riders dominated ownership of the higher capacity motorcycles whilst new riders favoured low powered mopeds and scooters. Those riders who used their motorcycles for leisure trips were more likely to be long-term and returning motorcyclists. Using retrospective data, it was found that those motorcyclists who had taken up the activity in recent years, increased the engine size of their machines more quickly, compared to earlier cohorts. Motorcycles purchased today are much more likely to be purchased for reasons of styling and image compared to previous cohorts who relied on them as a form of transport. The overall conclusion is that there is evidence of a shift in the nature of motorcycling in that it has, for some, become a leisure activity, with the motorcycle being more of accessory than a means of transport.