Cognitive functioning after medial frontal lobe damage including the anterior cingulate cortex: a preliminary investigation

Two patients with medial frontal lobe damage involving the anterior cingulate cortex (ACC) performed a range of cognitive tasks, including tests of executive function and anterior attention. Both patients lesions extended beyond the ACC, therefore caution needs to be exerted in ascribing observed deficits to the ACC alone. Patient performance was compared with age and education matched healthy controls. Both patients showed intact intellectual, memory, and language abilities. No clear-cut abnormalities were noted in visuoperceptual functions. Speed of information processing was mildly reduced only in Patient 2 (bilateral ACC lesion). The patients demonstrated weak or impaired performance only on selective executive function tests. Performance on anterior attention tasks was satisfactory. We tentatively suggest that our findings are inconsistent with anterior attention theories of ACC function based on neuroimaging findings. We propose that the data may imply that the ACC does not have a central role in cognition. We speculate that our findings may be compatible with the view that the ACC integrates cognitive processing with autonomic functioning to guide behaviour.     

Neural synchrony in stochastic resonance, attention, and consciousness.

We describe briefly three of our lab's ongoing projects studying the role of neural synchrony in human perception and cognition. These projects arise from two main interests: the role of noise both in human perception and in neural synchrony, and neural synchrony as a basis for integration of functional modules in the brain. Our experimental work on these topics began with a study of the possibility that noise-influenced neural synchrony might be responsible for the fact that small amounts of noise added to weak signals can enhance their detectability (stochastic resonance). We are also studying the role of neural synchrony in attention and consciousness in several paradigms. On the basis of our own and related work by others, we conclude that (1) neural synchrony plays an important role in the integration of functional modules in the brain and (2) neural synchrony is profoundly affected and possibly regulated, in part, by the "noisiness" of the brain.     

Emotional Responses to APO E Genotype Disclosure for Alzheimer Disease

The purpose of our study is to assess the emotional responses to disclosing APO E genotype to asymptomatic older adults at increased risk for Alzheimer disease (AD). This is a longitudinal cohort study of volunteer subjects who were aged 50 years or over, asymptomatic for (AD), had a family history of AD, passed a psychological assessment, and participated in pre- and post-test genetic counseling and three follow-up visits over 10 months. We analyzed responses by three emotional constructs: depressed, worried, and relieved. Three hundred and twenty-eight subjects were screened, 76 received their APO E genotype. When emotional responses occurred it was immediate, between baseline and the 1 month follow-up. Emotional reactions did not change significantly past 1 month. Our results suggest that for emotionally stable persons, disclosing results of their APO E genotype, high risk subjects did not report more depression or worry and low risk subjects felt relieved by knowing the results. Future studies should evaluate the risks of disclosure to family members involved in the diagnostic work-up of a relative and include subjects from a broader range of emotional stability and socioeconomic background.     

Age-related changes in children's hedonic response to male body odor

Male sweat smells disgusting to many adults, but it is unclear whether children find it so. In Experiment 1A, children (mean age = 8.7 years) and adolescents (M=16.6 years) smelled male sweat and other odors, rated each for liking, and attempted their identification. Only female adolescents disliked male sweat and could identify it. Experiment 1B, using the same procedure, obtained this gender difference in adults (M=26.7 years). In Experiment 2, children (M=8.1 years) and adolescents (M=16.6 years) were cued about the identity of the same odors. Irrespective of gender, adolescents disliked male sweat more than did children. In sum, dislike for the odor of male sweat may be an acquired social response that is based on odor identification.     

Accuracy in scientific discourse

Response to Rudmin, F. W. & Ahmadzadeh, V. (2001). Psychometric critique of acculturation psychology: The case of Iranian migrants in Norway.     

Historical misrepresentation in science: The case of fetal alcohol syndrome

The history of the fetal alcohol syndrome (FAS) provides a microcosm in which to explore the larger ramifications of historical citations in biomedical publications. Though some historical references such as Biblical writings may hint at a rudimentary understanding of the relationship between maternal drinking and fetal development, no definitive case can be made for an understanding of FAS dating back hundreds of years. Authors who claim an impressive history for FAS misrepresent that history. The modern history of FAS raises a question concerning citations of original discoveries. The first paper describing ethanol-induced damage to the fetus appeared in 1968 yet most researchers cite one of two papers from 1973. Both ancient citations and modern references to original discoveries pose difficult questions for the scientist. Both dilemmas may be solved by a better reading of the literature and a more judicious wording when writing about history. This work was supported in part by Grant # AA10681 to SNP.     

Sankara's fatal mistake

Sankara's philosophy fails definitively at the point where he leaves the human experience—’sinning and suffering‘—unaccounted for. What in each of us, he asks, sins and suffers? Is it the antahkarana, the ‘mental organ’ giving rise to the series of mental states (buddins) that file by illumined by the atman? Impossible, he says, for the antahkarana by itself is material (jada,) and therefore unconscious (acit). Then is it the ātman, upon which the antahkarana is superimposed? Inconceivable, he says, for the atman is identical with Brahman, and Brahman is by definition pure bliss‐consciousness, as far removed from sin and suffering as can be imagined. Then is the atman in conjunction with the antahkarana—a partnership that Sankara calls the jiva (or soul)—the sinner and sufferer? Yes, he says, as long as you remember that the sin and suffering are ultimately illusory, as illusory as the antahkarana itself. I show why Sankara's answer fails and what the failure implies, then suggest a fruitful way to approach Sankara and teach his philsophy to our students.     

Process and detection in fraud and deceit

There has been considerable interest recently in scientific misconduct. Although much has been written and discussed about specific cases, very little, if any, research has been carried out on the process of fraud. An understanding of this aspect can contribute much to methods of detection and lead to recommendations for preventing misconduct and for implementation of appropriate sanctions where fraud has been detected and proved. In this article I initiate a study of the process of fraud using a series of case studies. Hypotheses are generated by methods pioneered by Peirce and most recently developed and thoroughly discussed by Glaser and Strauss under the name of grounded theory. Some illustrations of what can be learned from such studies are included.