The Butterfly,the Mole and the Sage

Zhuangzi chooses a butterfly as a metaphor for transformation, a sighted creature whose inherent nature contains, and symbolizes, the potential for transformation from a less valued state to a more valued state. If transformation is not to be valued; if, according to a recent article by Jung Lee, ‘there is no implication that it is either possible or desirable for the living to awake from their dream’, why not tell a story of a mole awakening from a dream? This would be a more perfect story. There would be no point of a mole awakening since (setting aside tactile, olfactory, auditory and taste sensations for the purpose of the example), there is no way to distinguish between the world of the mole's imagination and the real world that is forever unavailable to a mole. In addition, Zhuangzi relates the story of the coming of a great sage in which it is clearly stated that ‘Only at the ultimate awakening shall we know that this is the ultimate dream’. Such textual evidence both from the choice of metaphors and evidential passages indicates that the message of the Zhuangzi is not epistemological relativity, but one of transformation from a state of intellectual blindness to a state of true understanding.     

Color and psychological functioning: the effect of red on performance attainment

This research focuses on the relation between color and psychological functioning, specifically, that between red and performance attainment. Red is hypothesized to impair performance on achievement tasks, because red is associated with the danger of failure in achievement contexts and evokes avoidance motivation. Four experiments demonstrate that the brief perception of red prior to an important test (e.g., an IQ test) impairs performance, and this effect appears to take place outside of participants' conscious awareness. Two further experiments establish the link between red and avoidance motivation as indicated by behavioral (i.e., task choice) and psychophysiological (i.e., cortical activation) measures. The findings suggest that care must be taken in how red is used in achievement contexts and illustrate how color can act as a subtle environmental cue that has important influences on behavior.     

Effects of response priming and inhibition on movement planning and execution

The authors used a precueing method to examine the effects of response priming and inhibition on goal-directed action. Participants (N = 18) completed aiming movements to 1 of 2 locations following predictive (80% cued), nonpredictive (50% cued), and antipredictive (20% cued) precues at 1 of the 2 possible target locations. Consistent with previous research, participants responded more quickly to targets at cued locations than to targets at uncued locations in the 80% condition, and more quickly to targets presented at the uncued than to those presented at cued locations in the 50% and 20% conditions. As predicted by models of action-centered selective attention, movement trajectories deviated away from the cued location in the 50% condition. Movement trajectories were also altered in the 80% and the 20% conditions. Movements directed to the uncued location deviated away from the cued location in the 80% condition, whereas movements directed to the cued location deviated away from the uncued location in the 20% condition. The authors explain the latter trajectory results as a strategy of overcompensation.     

Grammaticality sensitivity in children with early focal brain injury and children with specific language impairment

Grammaticality judgments and processing times associated with violation detection were examined in typically developing children, children with focal brain lesions (FL) acquired early in life, and children with specific language impairment (SLI). Grammatical sensitivity in the FL group, while below typically developing children, was above levels seen in children with SLI. Age effects were noted with developmental changes in sensitivity extending into adolescence. Developmental delays in grammatical processing were particularly pronounced for children with SLI, who showed sensitivity levels below those of younger typically developing children. Sensitivity to agreement violations was also protracted in the SLI group providing further evidence of the vulnerability of morphology, a pattern not unlike that seen in adult aphasics. Findings for the FL group provide compelling evidence of neural and behavioral plasticity in children with early unilateral brain injury. Moreover, results from these children underscore how very different compensatory organization may be compared to profiles seen in adult aphasics who have comparable lesions. In contrast, although it was expected that the SLI children would perform below the typically developing children, the disadvantage seen with respect to the FL group suggests that the underlying pathology responsible for SLI may be more pervasive and less plastic than the focal pathology of children with early brain damage.     

Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning

Previous functional magnetic resonance imaging (fMRI) studies have characterized brain systems involved in conditional response acquisition during Pavlovian fear conditioning. However, the functional neuroanatomy underlying the extinction of human conditional fear remains largely undetermined. The present study used fMRI to examine brain activity during acquisition and extinction of fear conditioning. During the acquisition phase, participants were either exposed to light (CS) presentations that signaled a brief electrical stimulation (paired group) or received light presentations that did not serve as a warning signal (control group). During the extinction phase, half of the paired group subjects continued to receive the same treatment, whereas the remainder received light alone. Control subjects also received light alone during the extinction phase. Changes in metabolic activity within the amygdala and hippocampus support the involvement of these regions in each of the procedural phases of fear conditioning. Hippocampal activity developed during acquisition of the fear response. Amygdala activity increased whenever experimental contingencies were altered, suggesting that this region is involved in processing changes in environmental relationships. The present data show learning-related amygdala and hippocampal activity during human Pavlovian fear conditioning and suggest that the amygdala is particularly important for forming new associations as relationships between stimuli change.     

Midazolam amnesia and retrieval from semantic memory: Developing methods to test theories of implicit memory

Studies of organic anterograde amnesia have been central to the development of theories of implicit memory. Pharmacological amnesia provides an additional method for exploring implicit memory, allowing for the experimental manipulation of amnesia and the testing of more participants. A significant concern with pharmacological amnesia is whether its cognitive effects are specific to explicit memory. The current research examines the effects of the benzodiazepine, midazolam, on retrieval from semantic memory and encoding in explicit memory. We focus on midazolam because it holds significant advantages over other benzodiazepines in inducing pharmacological amnesia and prior research suggests it may be useful for testing theories of implicit memory. Our results demonstrate that midazolam does not impair accuracy of retrieval from semantic categories, even when it produces anterograde amnesia for retrieved category items on a later recall test. These results suggest ways midazolam can be used to help test theories of implicit memory.     

Reliability of a portable head-mounted eye tracking instrument for schizophrenia research

Smooth pursuit eye movement (SPEM) abnormalities are some of the most consistently observed neurophysiological deficits associated with genetic risk for schizophrenia. SPEM has been traditionally assessed by infrared or video oculography using laboratory-based fixed-display systems. With growing interest in using SPEM measures to define phenotypes in large-scale genetic studies, there is a need for measurement instruments that can be used in the field. Here we test the reliability of a portable, head-mounted display (HMD) eye movement recording system and compare it with a fixed-display system. We observed comparable, modest calibration changes across trials between the two systems. The between-methods reliability for the most often used measure of pursuit performance, maintenance pursuit gain, was high (ICC = 0.96). This result suggests that the portable device is comparable with a lab-based system, which makes possible the collection of eye movement data in community-based and multicenter familial studies of schizophrenia.     

Lack of long-lasting consequences of starvation on eating pathology in Jewish Holocaust survivors of Nazi concentration camps

The purpose of the present study was to investigate whether Holocaust survivors will show the same eating pathologies that were found in other participants who had also undergone starvation. Fifty-five Holocaust survivors and 43 matched control participants answered a questionnaire designed to explore eating problems and pathologies described in the literature as lasting for decades after a period of severe food restriction. Confirmation of the survivors' reports was obtained from their children. No significant differences in current eating habits were found between the Holocaust survivors and their matched controls. Prolonged starvation in Holocaust survivors did not lead to disordered eating habits in the sample. These results conflict with the notion that severe starvation consistently leads to food preoccupation and disordered eating.     

Task-dependent modulation of target-flanker lateral interactions in vision

Visibility of a central target Gabor element often improves in the presence of collinear flankers. Such lateral interactions may reflect fundamental mechanisms underlying the perceptual integration of contours in early vision. We recently reported (Freeman, Sagi, & Driver, 2001) attentional modulation of these interactions. Here, we test whether this modulation is task dependent. Subjects had to detect a near-threshold central target while performing a secondary discrimination task on one pair of flankers that could appear with another distractor pair (one pair collinear with the target, the other orthogonal). Central target thresholds were lowered when collinear flankers were judged for the secondary task, but only when this task concerned the global spatial relationship between these flankers (discrimination of their Vernier offset or global orientation). Other secondary tasks involving discriminating the local orientations, contrasts, or colors of the relevant flanker pair produced no such attentional modulation. However, this task-dependent modulation was observed only when two flanker pairs were present, not for displays with only a single flanker pair. Top-down modulation of lateral interactions may function to select between overlapping potential contours whenever the global spatial properties of one are task relevant.