Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory

Many studies suggest sex differences in memory and hippocampal size, and that hormone therapy (HT) may positively affect these measures in women; however, the parameters of HT use that most likely confer benefits are debated. We evaluated the impact of sex and postmenopausal HT use on verbal learning and memory and hippocampal size in 94 cognitively intact women and 49 men. Using analysis of covariance that controlled for age and education, women had better total word learning and delayed verbal memory performance than men. HT analyses showed that non-HT users performed similarly to men, while HT users performed better than men in Delayed Memory regardless of whether use was current or in the past. Women had larger hippocampal volumes than men regardless of whether they were HT users. Using univariate linear models, we assessed group differences in the predictive value of hippocampal volumes for verbal learning and memory. Hippocampal size significantly predicted memory performance for men and non-HT users, but not for HT users. This lack of relationship between hippocampal size and verbal learning and memory performance in HT users suggests HT use may impact memory through extra-hippocampal neural systems.     

Imagination and immortality: thinking of me

Recent work in developmental psychology indicates that children naturally think that psychological states continue after death. One important candidate explanation for why this belief is natural appeals to the idea that we believe in immortality because we can’t imagine our own nonexistence. This paper explores this old idea. To begin, I present a qualified statement of the thesis that we can’t imagine our own nonexistence. I argue that the most prominent explanation for this obstacle, Freud’s, is problematic. I go on to describe some central features of contemporary cognitive accounts of the imagination, and I argue that these accounts provide an independently motivated explanation for the imaginative obstacle. While the imaginative obstacle does not dictate a belief in immortality, it does, I maintain, facilitate such a belief.     

Octopuses (Octopus bimaculoides) and cuttlefishes (Sepia pharaonis, S. officinalis) can conditionally discriminate

In complex navigation using landmarks, an animal must discriminate between potential cues and show context (condition) sensitivity. Such conditional discrimination is considered a form of complex learning and has been associated primarily with vertebrates. We tested the hypothesis that octopuses and cuttlefish are capable of conditional discrimination. Subjects were trained in two maze configurations (the conditions) in which they were required to select one of two particular escape routes within each maze (the discrimination). Conditional discrimination could be demonstrated by selecting the correct escape route in each maze. Six of ten mud-flat octopuses (Octopus bimaculoides), 6 of 13 pharaoh cuttlefish (Sepia pharaonis), and one of four common cuttlefish (S. officinalis) demonstrated conditional discrimination by successfully solving both mazes. These experiments demonstrate that cephalopods are capable of conditional discrimination and extend the limits of invertebrate complex learning.     

Intergenerational solidarity in the creation of science: The ross-sorokin correspondence, 1921–1931

The paper examines the relationship between two seminal figures in American sociology, in terms of its contribution to the movement to establish the science within the academic world. Using archival data, the analysis shows how Edward A. Ross and Pitirim A. Sorokin became acquainted and subsequently collaborated to expand the intellectual horizons and institutional base of sociology. Their collaboration is understood as intergenerational solidarity, which the paper argues is fundamental to an understanding of both the past and the future of organized sciences.     

Natural Compatibilism,Indeterminism, and Intrusive Metaphysics

The claim that common sense regards free will and moral responsibility as compatible with determinism has played a central role in both analytic and experimental philosophy. In this paper, we show that evidence in favor of this “natural compatibilism” is undermined by the role that indeterministic metaphysical views play in how people construe deterministic scenarios. To demonstrate this, we re-examine two classic studies that have been used to support natural compatibilism. We find that although people give apparently compatibilist responses, this is largely explained by the fact that people import an indeterministic metaphysics into deterministic scenarios when making judgments about freedom and responsibility. We conclude that judgments based on these scenarios are not reliable evidence for natural compatibilism.     

If Folk Intuitions Vary,Then What?

We have recently presented evidence for cross‐cultural variation in semantic intuitions and explored the implications of such variation for philosophical arguments that appeal to some theory of reference as a premise. Devitt (2011) and Ichikawa and colleagues (forthcoming) offer critical discussions of the experiment and the conclusions that can be drawn from it. In this response, we reiterate and clarify what we are really arguing for, and we show that most of Devitt’s and Ichikawa and colleagues’ criticisms fail to address our concerns.     

Short-Term Effect of Crural Fasciotomy on Kinematic Variability and Propulsion During Level Locomotion

Treadmill locomotion can be characterized by consistent step-to-step kinematics despite the redundant degrees of freedom. The authors investigated the effect of disrupting the crural fascia in decerebrate cats to determine if the crural fascia contributed to kinematic variability and propulsion in the limb. Crural fasciotomy resulted in statistically significant decreases in velocity and acceleration in the joint angles during level walking, before, during, and after paw-off, particularly at the ankle. A further finding was an increase in variance of the limb segment trajectories in the frontal plane. The crural fascia therefore provides force transmission and reduction in kinematic variability to the limb during locomotion.