Understanding youth antisocial behavior using neuroscience through a developmental psychopathology lens: Review,integration, and directions for research

Youth antisocial behavior (AB) is an important public health concern impacting perpetrators, victims, and society. Functional neuroimaging is becoming a more common and useful modality for understanding neural correlates of youth AB. Although there has been a recent increase in neuroimaging studies of youth AB and corresponding theoretical articles on the neurobiology of AB, there has been little work critically examining the strengths and weaknesses of individual studies and using this knowledge to inform the design of future studies. Additionally, research on neuroimaging and youth AB has not been integrated within the broader framework of developmental psychopathology. Thus, this paper provides an in-depth review of the youth AB functional neuroimaging literature with the following goals: (1) to evaluate how this literature has informed our understanding of youth AB, (2) to evaluate current neuroimaging studies of youth AB from a developmental psychopathology perspective with a focus on integrating research from neuroscience and developmental psychopathology, as well as placing this research in the context of other related areas (e.g., psychopathy, molecular genetics), and (3) to examine strengths and weaknesses of neuroimaging and behavioral studies of youth AB to suggest how future studies can develop a more informed and integrated understanding of youth AB.     

Directed forgetting for categorised pictures: recognition memory for perceptual details versus gist

ABSTRACT

Item-based directed forgetting (DF) was tested using 2-alternative forced-choice recognition to examine the effects of forgetting instructions on memory for perceptual detail and gist of categorised pictures of scenes and objects in three experiments. When the distractor is from the same category as the target (exemplar test condition), discrimination must be based on memory for perceptual details, whereas recognition can be based on gist or general category information when the distractor is from a novel category (novel test condition). Recognition accuracy was greater for Remember-cued than Forget-cued pictures when discrimination must be based on perceptual details in the exemplar test condition but not when discrimination could be based on gist in the novel test condition. Accuracy in scene and object recognition is greater for gist than for perceptual details, and DF instructions serve to reduce recognition memory based on perceptual details.     

Patients as Teaching Tools: Merely Informed or True Consent

Using patients as teaching tools raise many ethical issues like informed consent, privacy, confidentiality and beneficence. The current study highlights issues on respecting patient’s choice and acquiring informed consent with its spirit rather than as mere formality. The study was conducted in out-patient department of The Kidney Center Postgraduate Training Institute Karachi Pakistan in May 2008 to July 2008. All patients who had come for the first time to see the author were included in the study. The said study explored the willingness of patients to allow medical students to be present during history taking and physical examination by the consultant. There were 18 male and 03 female patients. Age ranging from 22 to 73 years with mean age of 53.5 ± 13.7 years. There were total of 21 patient–students encounters out of which two encounters were with male students only and two with female students only. So in 17 Patient–students encounters, students of both genders were present. All patients permitted history taking in the presence of medical students except one who had a history of extramarital sexual contact and signs and symptoms suggestive of sexually transmitted disease. Of the male patients 50% (9/18) did not allow intimate examination before medical students. Out of these nine patients who refused, four consented earlier but when enquired again about their true willingness, they expressed their preference not to have medical students in the room while undergoing digital rectal and external genital examinations. Physicians need to develop sensitivity to acquire informed consent in its true essence rather than just as a formality by exploring actual willingness of the patient. One should refrain from being judgmental on the basis of gender, looks, religion or norms.     

Using mouse models to explore genotype-phenotype relationship in Down syndrome

Down Syndrome (DS) caused by trisomy 21 is characterized by a variety of phenotypes and involves multiple organs. Sequencing of human chromosome 21 (HSA21) and subsequently of its orthologues on mouse chromosome 16 have created an unprecedented opportunity to explore the complex relationship between various DS phenotypes and the extra copy of approximately 300 genes on HSA21. Advances in genetics together with the ability to generate genetically well-defined mouse models have been instrumental in understanding the relationships between genotype and phenotype in DS. Indeed, elucidation of these relationships will play an important role in understanding the pathophysiological basis of this disorder and helping to develop therapeutic interventions. A successful example of using such a strategy is our recent studies exploring the relationship between failed nerve growth factor (NGF) transport and amyloid precursor protein (App) overexpression. We found that increased dosage of the gene for App is linked to failed NGF signaling and cholinergic neurodegeneration in a mouse model of DS. Herein, we discuss several mouse models of DS and explore the emergence of exciting new insights into genotype-phenotype relationships, particularly those related to nervous system abnormalities. An important conclusion is that uncovering these relationships is enhanced by working from carefully defined phenotypes to the genes responsible.     

Distinguishing familiarity from fluency for the compound word pair effect in associative recognition

We examined whether processing fluency contributes to associative recognition of unitized pre-experimental associations. In Experiments 1A and 1B, we minimized perceptual fluency by presenting each word of pairs on separate screens at both study and test, yet the compound word (CW) effect (i.e., hit and false-alarm rates greater for CW pairs with no difference in discrimination) did not reduce. In Experiments 2A and 2B, conceptual fluency was examined by comparing transparent (e.g., hand bag) and opaque (e.g., rag time) CW pairs in lexical decision and associative recognition tasks. Lexical decision was faster for transparent CWs (Experiment 2A) but in associative recognition, the CW effect did not differ by CW pair type (Experiment 2B). In Experiments 3A and 3B, we examined whether priming that increases processing fluency would influence the CW effect. In Experiment 3A, CW and non-compound word pairs were preceded with matched and mismatched primes at test in an associative recognition task. In Experiment 3B, only transparent and opaque CW pairs were presented. Results showed that presenting matched versus mismatched primes at test did not influence the CW effect. The CW effect in yes-no associative recognition is due to reliance on enhanced familiarity of unitized CW pairs.     

The addiction-stroop test: Theoretical considerations and procedural recommendations

Decisions about using addictive substances are influenced by distractions by addiction-related stimuli, of which the user might be unaware. The addiction-Stroop task is a paradigm used to assess this distraction. The empirical evidence for the addiction-Stroop effect is critically reviewed, and meta-analyses of alcohol-related and smoking-related studies are presented. Studies finding the strongest effects were those in which participants had strong current concerns about an addictive substance or such concerns were highlighted through experimental manipulations, especially those depriving participants of the substance. Theories to account for addiction-related attentional bias are discussed, of which the motivational theory of current concerns appears to provide the most complete account of the phenomenon. Recommendations are made for maximizing the precision of the addiction-Stroop test in future research.     

Motivation in a MOOC: a probabilistic analysis of online learners’ basic psychological needs

Self-determination theory (SDT) is one of the most well-known approaches to achievement motivation. However, the three basic psychological needs of SDT have not received equivalent attention in the literature: priority has been given to autonomy, followed by the need for competence, with research into relatedness lacking (Bachman and Stewart in Teach Psychol 38: 180–187, 2011. doi: 10.1177/0098628311411798). One new educational setting where relatedness may be particularly important is massive open online courses (MOOCs), which provide unprecedented opportunities for either relatedness or isolation. The purpose of the research was to use Bayesian networks (BN) to establish probabilistic relationships between learners’ basic psychological needs in the context of one MOOC. The majority (59 %) of participants (N = 1037; 50 % female and 50 % male) were under 45 (age range was 18–74 years). This sample represented approximately 88 regions and countries. Participants completed a revised Basic Student Needs Scale (Betoret and Artiga in Electron J Res Educ Psychol 9(2): 463–496, 2011). In order to reveal the best structural understanding of SDT within a MOOC learning environment, analysis of the data involved the development of a BN probabilistic model. The best fitting BN model included autonomy, competence, and relatedness—resulting in a probabilistic accuracy of 77.41 %. Analyses revealed participants with high autonomy had an 80.01 % probability of having a moderate level of competence. Relatedness was distinct from the autonomy and competence relationship. The strong inter-connections between autonomy and competence support existing research. The notion that relatedness may be a distinct need, at least in this context, was supported and warrants future research.     

Treating minorities with fatwas: a study of the Ahmadiyya community in Indonesia

The term “minority religious community” in the Muslim country of Indonesia refers not only to those embracing religions other than Islam, but also to minority groups like the Ahmadiyya. Recently, the treatment of Ahmadis has been worse than the treatment of non-Muslims. This article, therefore, intends to study the status of ‘deviant’ groups under Islamic law and the treatment of them in Muslim society. Specifically, this article addresses the following questions: How did ulama in the past define and treat minority groups? How do contemporary Sunni ulama define and treat the Ahmadiyya? What is the status of this group under Islamic law? Are they apostates, heretics, or unbelievers? And what are the legal consequences of these charges? To answer these questions, this article employs two methods. First, for theoretical treatment of minority groups in the past, this article focuses its analysis on al-Ghazāli’s Fay?al al-tafriqa and Fa?ā’i? al-bā?iniyya. Second, following a discussion of classical Islam, the article moves to contemporary time by analyzing fatwas against the Ahmadiyya from five institutions: the Rābi?a al-‘?lam al-Islāmī, Majelis Ulama Indonesia (MUI), Muhammadiyah, Council of the Islamic Fiqh Academy of the Organization of Islamic Cooperation (OIC), and Nahdlatul Ulama (NU). This article argues that, first, fatwas against the Ahmadiyya issued by these institutions were intended as a device to sustain orthodoxy of umma and, second, orthopraxy or devoutness in observing religious rituals, as practiced by the Ahmadis, does not exempt them from the charge of apostasy because theologically they are believed to deviate from orthodox beliefs.     

Hating the Ahmadiyya: the place of “heretics” in contemporary Indonesian Muslim society

Religious diversity and pluralism is commonly understood within the context of the relation between various religious traditions, not within a single religious tradition. This limitation of the boundary of religious pluralism could overlook the fact that conflict within a single tradition can be bitterer and more disastrous than conflict with other religions. In the last decade, for instance, the Ahmadis in Indonesia have become victims of constant attacks. This article, therefore, intends to study the place of the Ahmadiyya in the context of religious pluralism in Indonesia by answering the following questions: Why was the treatment of the Ahmadis in recent years by Muslims more vitriolic than their treatment of non-Muslims? What is the nature and quality of life for people who have been excluded from a ‘normal’ religious identity in a time when religious attachment is a necessary fact for that society? Why did the attacks on the Ahmadiyya occur in the present regime, not during the past authoritarian one? This article argues that the charge of heresy issued by Muslim institutions put the Ahmadiyya in liminal status; they are in the zone of indistinction between Muslims and non-Muslims. This makes them vulnerable to persecution since they have been deprived of their rights as Muslims, while their rights as non-Muslims are still suspended. Non-Muslims, particularly ahl al-kitāb (People of the Book), have been accepted theologically in Muslim society, but there is no place of tolerance for heretics. The rise of intolerance in Indonesia parallels the rise of religious conservatism after the fall of Suharto in 1998.