Analysis of five cases with neurogenic stuttering following brain injury in the basal ganglia

This study examined stuttering patterns in five patients with basal ganglia injury. None of the patients had a history of developmental stuttering. Four patients were right-handed; one patient was ambidextrous. Stuttering tests administered to patients assessed sentence repetition, reading aloud, explanations of a comic strip, and conversation. Accessory behaviors such as facial grimaces, associated movements of the limbs, and avoidance behaviors were observed. The results of this study differ from those of previous studies of neurogenic stuttering in several respects: (1) blocks were frequently observed. (2) Adaptation was observed. (3) Almost all stuttering occurred at the initiation of words. (4) Across patients, stuttering frequency did not vary in a consistent manner with speaking task. New speech characteristics for neurogenic stuttering without aphasia following injury to the basal ganglia are described.Educational objectives: After reading this text, the reader will be able to: (1) provide characteristics of neurogenic stuttering after the basal ganglia in patients without aphasia; (2) discuss the difference of the features and characteristics of stuttering between previously reported patients and present patients.     

Characteristics of Family Interaction of Individuals with Hikikomori (Prolonged Social Withdrawal) From the Viewpoint of Behavior Theory

The cognitive behavioral approach for families of individuals with hikikomori (IWH) places importance on assessing family interaction from a behavior theory. However, there is no gold standard method for the assessment of family interaction of IWH. Additionally, the characteristics of the family interactions of IWH have not been clarified. This study aims to (a) develop the Family Interaction Scale for Hikikomori (FIS‐H) using parent‐reported data, and (b) clarify the characteristics of hikikomori cases. First, the FIS‐H factor structure was examined. Second, to examine the reliability and validity of the FIS‐H and the characteristics of hikikomori cases, parents of IWH (hikikomori‐group) and unaffected parents (without‐group) completed the FIS‐H and the Relationship Happiness Scale. Based on data from 146 parents, the FIS‐H preliminary version consisted of four factors with a total of 12 items (Study 1). The reliability and validity of the FIS‐H were also confirmed to be acceptable using data from 246 hikikomori‐group participants. The hikikomori‐group had higher FIS‐H scores than did the without‐group (Study 2). These results show that it is important to appropriately assess family interactions.     

Formation of icosahedral quasicrystals in an annealed Zr65Al7.5Ni10Cu12.5Ag5 metallic glass

The formation and thermal stability of an icosahedral quasicrystalline phase in an annealed Zr₆₅Al_7.5Ni₁₀Cu_12.5Ag₅ metallic glass have been investigated by X-ray diffraction and transmission electron microscopy analyses. It was found that the quasicrystalline phase can precipitate from the glassy state and the supercooled liquid of the alloy over a wide range of annealing temperatures. After optimizing the heat-treatment conditions, the volume fraction of the quasicrystalline phase in the alloy can reach as high as about 80%. Investigation of the thermal stability of the quasicrystalline phase demonstrates that it is very stable when the annealing temperature is below the glass transformation temperature T _g of the alloy.     

Emergence of rhythm during motor learning

Complex motor skill often consists of a fixed sequence of movements. Recent studies show that a stereotyped temporal pattern or rhythm emerges as we learn to perform a motor sequence. This is because the sequence is reorganized during learning as serial chunks of movements in both a sequence-specific and subject-specific manner. On the basis of human imaging studies we propose that the formation of chunk patterns is controlled by the cerebellum, its posterior and anterior lobes contributing, respectively, to the temporal patterns before and after chunk formation. The motor rhythm can assist the motor networks in the cerebral cortex to control automatic movements within chunks and the cognitive networks to control non-automatic movements between chunks, respectively. In this way, organized motor skill can be performed automatically and flexibly.     

Chronic stress, metabolism, and metabolic syndrome

The prevalence of obesity has rapidly escalated and now represents a major public health concern. Although genetic associations with obesity and related metabolic disorders such as diabetes and cardiovascular disease have been identified, together they account for a small proportion of the incidence of disease. Environmental influences such as chronic stress, behavioral and metabolic disturbances, dietary deficiency, and infection have now emerged as contributors to the development of metabolic disease. Although epidemiological data suggest strong associations between chronic stress exposure and metabolic disease, the etiological mechanisms responsible remain unclear. Mechanistic studies of the influence of chronic social stress are now being conducted in both rodent and nonhuman primate models, and phenotypic results are consistent with those in humans. The advantage of these models is that potential neural mechanisms may be examined and interventions to treat or prevent disease may be developed and tested. Further, circadian disruption and metabolic conditions such as diabetes mellitus could increase susceptibility to other stressors or serve as a stressor itself. Here, we review data from leading investigators discussing the interrelationship between chronic stress and development of metabolic disorders.     

Development of a cognitive function test using virtual reality technology: examination in healthy participants

We developed a virtual reality test to assess the cognitive function of Japanese people in near-daily-life environment, namely, a virtual shopping test (VST). In this test, participants were asked to execute shopping tasks using touch panel operations in a “virtual shopping mall.” We examined differences in VST performances among healthy participants of different ages and correlations between VST and screening tests, such as the Mini–Mental State Examination (MMSE) and Everyday Memory Checklist (EMC). We included 285 healthy participants between 20 and 86 years of age in seven age groups. Therefore, each VST index tended to decrease with advancing age; differences among age groups were significant. Most VST indices had a significantly negative correlation with MMSE and significantly positive correlation with EMC. VST may be useful for assessing general cognitive decline; effects of age must be considered for proper interpretation of the VST scores.     

Set-size effects in simple visual search for contour curvature

In a visual-search paradigm, both perception and decision processes contribute to the set-size effects. Using yes - no search tasks in set sizes from 2 to 8 for contour curvature, we examined whether the set-size effects are predicted by either the limited-capacity model or the decision-noise model. There are limitations in perception and decision-making in the limited-capacity model, but only in decision-making in the decision-noise model. The results of four experiments showed that the slopes of the logarithm of threshold plotted against the logarithm of set size ranged from 0.24 to 0.32, when the curvature was high or low, contour convexity was upward or downward, and stimulus was masked or unmasked. These slopes were closer to the prediction of 0.23 by the decision-noise model than that of 0.73 by the limited-capacity model. We interpret this that in simple visual search for contour curvature, the decision noise mainly affects the set-size effects and perceptual capacity is not limited.     

Predictive and postdictive mechanisms jointly contribute to visual awareness

One of the fundamental issues in visual awareness is how we are able to perceive the scene in front of our eyes on time despite the delay in processing visual information. The prediction theory postulates that our visual system predicts the future to compensate for such delays. On the other hand, the postdiction theory postulates that our visual awareness is inevitably a delayed product. In the present study we used flash-lag paradigms in motion and color domains and examined how the perception of visual information at the time of flash is influenced by prior and subsequent visual events. We found that both types of event additively influence the perception of the present visual image, suggesting that our visual awareness results from joint contribution of predictive and postdictive mechanisms.     

Contrast effect in evaluating palatability of beverages.

This study aimed to clarify the contextual effect in evaluation of the pleasantness of beverages. Participants were presented a test stimulus and were then asked to rate how much they liked it before and after presentation of a contextual stimulus. Specifically, after participants were exposed to a less palatable beverage, they evaluated the test beverage as being more palatable than when their judgment of a test drink occurred after presentation of a neutral or palatable beverage (a positive contrast effect). This contextual effect can be explained by the reasoning that participants were affectively adapted to the palatability (less palatable) of a less palatable stimulus after repeated exposure; thus, they evaluated the test stimulus as more palatable. This study suggests that the evaluated value of the contextual stimuli affects evaluation of the test stimulus. The authors also suggest that these context effects are probably found in everyday life.