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261.
Plaschke K Feindt J Djuric Z Heiland S Autschbach F Lewicka S Martin E Bardenheuer HJ Nawroth PP Bierhaus A 《Stress (Amsterdam, Netherlands)》2006,9(2):97-106
We investigated whether long-lasting stress induced by chronic glucocorticoid (GC) exposure affects activation of brain NF-kappaB and whether these changes are related to functional deterioration and structural changes in the rat hippocampus. Psychometric investigations were conducted using a holeboard test system in 28 one-year-old male Wistar rats. Thereafter, rats were divided into three groups for daily administration of 10 mg corticosterone (treatment) or sesame oil (placebo = sham control for effects of the vehicle) for 60 days. Additional control rats did not receive any treatment or handling until the end of the experiment. Behavioural and cognitive changes were tested again in the holeboard system. Rat body weights and corticosterone concentrations in plasma, hippocampus and urine were determined and adrenal glands were investigated histopathologically. Hippocampal concentrations of corticosterone, NF-kappaB and I-kappaBalpha were determined using RIA, EMSA and Western blotting techniques, respectively. Structural changes in rat hippocampus were measured using magnetic resonance imaging techniques. High peripheral corticosterone concentrations after chronic treatment led to significant reductions in rat body weight. Significant atrophy of both adrenal glands with marked histological deterioration was detected. Furthermore, an increase in hippocampal corticosterone concentrations was observed after chronic administration. Chronic corticosterone treatment also significantly altered behaviour and working and reference memory capacity without changing hippocampal structure. Daily injections of sesame oil in the placebo group, however, were also sufficient to reduce the pellet-finding time. However, neither in the corticosterone group nor in the placebo group were behavioural changes paralleled by significant changes in brain NF-kappaB activation and I-kappaBalpha expression. Thus, cognitive alterations in rats seen after chronic corticosterone exposure are not paralleled by hippocampal NF-kappaB modulation. 相似文献
262.
Windmann S Schneider T Reczio J Grobosch M Voelzke V Blasius V Brämer A Ischebeck W Janikowski G Mandrella W Unger C Wischnjak L 《Cognitive, affective & behavioral neuroscience》2006,6(4):270-276
In recognition memory tasks, emotionally negative words are judged more often as "old" relative to emotionally neutral words, suggesting a shift in response bias. We wondered whether this bias shift was due to the flexible regulation of executive control during memory retrieval. To address this question, we investigated individuals with high variability in executive control functions. As expected, we observed that emotional word meaning did indeed have a strong influence on the bias toward responding "old," independent of recognition accuracy and overall response bias. However, these effects were uncorrelated with executive control, as measured by the Trail Making Test, and were fully intact, even in a sample of hospitalized neurological patients with severe executive dysfunctions, some of whom had marked damage in fronto-thalamo-striatal networks. Having concluded that the emotion-induced bias must develop on different grounds, we went on to discuss alternative explanations. 相似文献
263.
Using a lexical decision task, the authors investigated whether brain asymmetries in the detection of emotionally negative semantic associations arise only at a perceptually discriminative stage at which lexical analysis is accurate or can already be found at crude and incomplete levels of perceptual representation at which word-nonword discrimination is based solely on guessing. Emotionally negative and neutral items were presented near perceptual threshold in the left and right visual hemifields. Word-nonword discrimination performance as well as the bias to classify a stimulus as a "word" (whether or not it actually is a word) were assessed for a normal, horizontal stimulus presentation format (Experiment 1) and for an unusual, vertical presentation format (Experiment 2). Results show that while the two hemispheres are equally able to detect affective semantic associations at a prelexical processing stage (both experiments), the right hemisphere is superior at a postlexical, perceptually discriminative stage (Experiment 2). Moreover, the findings suggest that only an unusual, nonoverlearned stimulus presentation format allows adequate assessment of the right hemisphere's lexical-semantic skills. 相似文献
264.
Buhlmann U Wilhelm S McNally RJ Tuschen-Caffier B Baer L Jenike MA 《CNS spectrums》2002,7(6):435-6, 441-3
Anxiety-disordered patients and individuals with high trait anxiety tend to interpret ambiguous information as threatening. The purpose of this study was to investigate whether interpretive biases would also occur in body dysmorphic disorder (BDD), which is characterized by a preoccupation with imagined defects in one's appearance. We tested whether BDD participants, compared with obsessive-compulsive disorder participants and healthy controls, would choose threatening interpretations for ambiguous body-related, ambiguous social, and general scenarios. As we hypothesized, BDD participants exhibited a negative interpretive bias for body-related scenarios and for social scenarios, whereas the other groups did not. Moreover, both clinical groups exhibited a negative interpretive bias for general scenarios. 相似文献
265.
Memory consolidation for the discrimination of frequency-modulated tones in mongolian gerbils is sensitive to protein-synthesis inhibitors applied to the auditory cortex 总被引:3,自引:1,他引:2
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Kraus M Schicknick H Wetzel W Ohl F Staak S Tischmeyer W 《Learning & memory (Cold Spring Harbor, N.Y.)》2002,9(5):293-303
Differential conditioning of Mongolian gerbils to linearly frequency-modulated tones (FM) has recently received experimental attention. In the study of the role of cerebral protein synthesis for FM discrimination memory, gerbils received post-training bilateral injections of anisomycin into the auditory cortex under light halothane anesthesia. Compared with saline-treated controls, anisomycin-treated gerbils showed a discrimination decrement during the subsequent three days of training. They markedly improved their performance within training sessions, but started each session at low levels. When repeatedly trained gerbils received post-session injections of anisomycin, discrimination performance during subsequent sessions was similar to the pre-injection performance, indicating that retention, retrieval, reconsolidation, and expression of the established reaction were not affected. However, the improvement of a partially established discrimination reaction was impaired after this treatment. Intracortical injections of emetine confirmed this finding. Neither drug affected FM discrimination learning when given several days before the initial training. Our results suggest that protein-synthesis inhibitors applied to the auditory cortex of gerbils during the post-acquisition phase interfered with learning and memory-related aspects of FM processing. The resulting deficit was evident for a number of post-injection training days. This effect was probably due to impaired consolidation, i.e., processes required for long-term stabilization or retrieval of the memory trace while leaving short-term memory intact. 相似文献
266.
The present research questions whether mere valence affects self-other comparisons in the domain of trait characteristics. While some previous studies have reported greater positivity bias for the self when traits were positive than when traits were negative, we suggest that this is an ambiguous finding, because valence and content were confounded. When we unconfounded content and valence, valence had no effect on the magnitude of self-positivity bias displayed. We also replicate several findings for our unconfounded set of traits. Firstly, comparing others to the self, rather than comparing the self to others, lowered self-positivity for positive and negative traits (focus effect). Secondly, extremely positive and negative traits triggered greater positivity bias than did more moderately evaluated ones. Finally, we suggest that comparative self-positivity biases may be based on a general positivity bias. 相似文献
267.
Memory illusions--vivid experiences of events that never occurred--could result from inaccuracies either in retrieving memories or in initially storing them. In two experiments, people studied lists of associated words that either did or did not induce later illusory (false) memories of associated but nonpresented lure words. The amplitude of the electrical brain activity during study of words (approximately 500-1,300 ms) that were themselves later correctly remembered reliably distinguished list words that led to such illusory memories from those that did not. This encoding difference associated with subsequent illusory memory (referred to as a DIM)--presumably reflecting item-specific encoding differences--is a neural precursor of memory illusions. 相似文献
268.
The contention of this article is that, since its inception in the mid-twentieth century, mainstream psycholinguistics has been monologistic, that is, has concentrated on monologue as its source of empirical material and has, largely implicitly, involved a monologistic epistemology. The article is not a comprehensive history of psycholinguistics but does attempt to establish a historical perspective. Monologism has been the historical bias of Cartesianism, positivism, behaviorism, and cognitivism. Monologism is concerned only with the person in whom cognition takes place and from whom communication proceeds. It is essentially asocial. By contrast, the merits of dialogism include an openness to the sociocultural, interactive nature of all cognition and communication and an empirical engagement of contextualized discourse situations. Dialogism is presented here not as a supplement to mainstream psycholinguistics but as a radical innovation that construes mainstream psycholinguistics as "strongly misleading if presented as a full theory of communication through spoken interaction" (Linell, 1998, p. 23). Some approaches to dialogism and research on dialogue are critically reviewed. 相似文献
269.
270.
Stephanie Kelter Holger Grötzbach Ralf Freiheit Barbara Höhle Sabine Wutzig Eugen Diesch 《Memory & cognition》1984,12(2):123-133
In two experiments, subjects indicated whether two pictures of familiar objects were equivalent. The picture pairs were identical, showed the same object in various perspectives and states, or showed different objects with varying degrees of conceptual relatedness. In Experiment 1, the equivalence criterion for judging the picture pairs was varied between subjects (identity of pictures; conceptual equivalence of objects at subordinate, basic, or superordinate level). The reaction times of the four subject groups suggest that a pictorial stimulus is not always mentally represented in the same way, and that the instructions given determine which attributes of the stimulus are represented. In Experiment 2, the visual similarity of the picture pairs was varied. The results indicate, at least with a basic-level equivalence instruction, that not only perceptual, but also non-perceptual, functional attributes are represented—namely, those that, according to Rosch et al. (1976), are common to the members of a superordinate category. 相似文献