Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle

The cannabinoid CB1 receptor has been shown to be critically involved in the extinction of fear memory. Systemic injection of a CB1 receptor antagonist prior to extinction training blocked extinction. Conversely, administration of the cannabinoid uptake inhibitor AM404 facilitated extinction in a dose-dependent manner. Here we show that bilateral infusion of CB1 receptor agonists into the amygdala after memory reactivation blocked reconsolidation of fear memory measured with fear-potentiated startle. The effect was dose-dependent and could be blocked by AM251, a specific CB1 receptor antagonist. In contrast, the effect of CB1 agonists on reconsolidation was no longer seen if memory reactivation was omitted. Concomitant with block of reconsolidation, CB1 agonist-treated animals did not exhibit shock-induced reinstatement or spontaneous recovery of fear. The absence of recovery was not attributable to permanent damage to the amygdala in WIN-treated rats, nor did the effect result from alteration of baseline startle or shock reactivity. These results suggest that CB1 agonists could impair fear memory via blocking reconsolidation.     

Action orientation overcomes the ego depletion effect

It has been consistently demonstrated that initial exertion of self‐control had negative influence on people's performance on subsequent self‐control tasks. This phenomenon is referred to as the ego depletion effect. Based on action control theory, the current research investigated whether the ego depletion effect could be moderated by individuals' action versus state orientation. Our results showed that only state‐oriented individuals exhibited ego depletion. For individuals with action orientation, however, their performance was not influenced by initial exertion of self‐control. The beneficial effect of action orientation against ego depletion in our experiment results from its facilitation for adapting to the depleting task.     

论罗尔斯的政治义务理论

政治义务是政治哲学的核心问题。哈特首先用“相互限制原则”来解释政治义务,这一原则为罗尔斯所继承并加以修正。鉴于该原则存在的诸多问题,罗尔斯在《正义论》中削减了它在政治义务的道德证明中的作用,而诉诸正义的自然责任原则。这个原则仍然受到来自多方面的批评,许多罗尔斯的追随者对这些批评作了回应。罗尔斯从公平游戏原则到自然责任原则的转变反映了他对契约论不同的态度。     

《太平经》的和谐观

世界是人、社会、自然的复合生态系统,各要素之间相互联系,相互作用,维持着整个世界的和谐。成书于我国东汉中期的《太平经》,又称《太平清领书》,是道教早期的重要经典。我国传统思想中的“天人合一”的基本命题和这个命题所表现的“体用一源”的思维模式,熔铸了一种独特的宇宙人生理论。汤一介先生称之为“普遍和谐观念”①。这种“普遍和谐观念”在《太平经》中至少包括四个层次,即自然界的和谐、人与自然、人与人、人自我身心的和谐,本质上体现为一种整体和谐观念。一、自然界的和谐《太平经》继承并发展了老子《道德经》“道生一,一生…     

Adapting to an initial self-regulatory task cancels the ego depletion effect

The resource-based model of self-regulation provides a pessimistic view of self-regulation that people are destined to lose their self-control after having engaged in any act of self-regulation because these acts deplete the limited resource that people need for successful self-regulation. The cognitive control theory, however, offers an alternative explanation and suggests that the depletion effect reflects switch costs between different cognitive control processes recruited to deal with demanding tasks. This account implies that the depletion effect will not occur once people have had the opportunity to adapt to the self-regulatory task initially engaged in. Consistent with this idea, the present study showed that engaging in a demanding task led to performance deficits on a subsequent self-regulatory task (i.e. the depletion effect) only when the initial demanding task was relatively short but not when it was long enough for participants to adapt. Our results were unrelated to self-efficacy, mood, and motivation.     

弱智儿童在上课时和自由活动时的行为表现

研究了４１名弱智儿童。采用时间样本的方法收集材料,以期从动态角度了解弱智儿童在上课时和自由活动时的行为表现。按园别和智力落后程度两个方面对被试在上课时的８大类行为和自由活动时的７大类行为进行了分析。结果发现：班级人数、不同教学方法和智力落后程度与弱智儿童的行为表现有关。还对收集材料的方法、园别和智力落后程度与弱智儿童的行为表现的关系、高频率的自娱活动等,进行了讨论。最后,根据研究结果对教师提出了教学建议。     

关于闪光盲的研究——Ⅱ 短暂强闪光对中心视觉恢复时间的影响

在暗适应条件下对11名正常视力的男性受试者测定了进入眼内的闪光能量与恢复时间的关系。当闪光时间为0.1—5毫秒,积分亮度为0.07—1.69熙提秒时,人眼辨别一6’视角的蓝道环缺口所需的恢复时间仅取决于亮度和曝光时间的乘积,即Bloch律成立。文章并对防闪光盲护目镜应具的关闭时间进行了讨论。     

智力落后儿童用左、右手抓物的实验研究

本研究旨在探讨智力落后儿童在实验情景下用手抓物的方式、及其与大脑侧偏化的关系。结果表明:(1)智力落后儿童混用手情况多。被试在取物时,使用左手或右手次数的比率平均约为1:2,相当于1—2岁正常儿童用左、右手取物的比率;(2)性别与年龄对落后儿童用手方式无明显影响;(3)病情等级对用手方式有明显影响:轻度智力落后儿童使用左、右手的比率大于中、重度智力落后儿童的同样比率;(4)智力落后儿童抓物的线索在四个实验中不完全相同:实验Ⅰ至Ⅲ的线索为位置(近手),实验Ⅳ为对实验用具的喜爱;(5)在混用手与大脑侧偏化(或优势脑未分化)不完善之间,可能有直接关系。此问题尚需进一步研究。     

文化转型期刘师培的经学研究

处于传统与现代之间的文化转型期,刘师培从思想自由的角度批判了传统经学作为意识形态对人们思想的控制,又从字义考证入手彻底解构和颠覆了经学作为价值准则的合法性地位,同时借助于西学对传统经学进行新的阐释,为现代新文化的构建提供资源,从而开启了经学研究的近代之路。     

项目反应理论框架下的新等值方法——对数对比等值法

项目反应理论有一些以除法形式给出的多级评分模型,若采用Haebara等值法、Stocking_Lord等值法或对称相对熵等值法进行测验等值,都因其对初值有较高要求而可能导致失败。针对这一类模型,我们给出了一种新的等值方法——对数对比等值法。这种方法收敛快,对迭代初值要求低,所得结果精度较高,可以为其他等值方法提供良好的初值。研究表明,对数对比等值法还改进和推广了0-1评分的两参数Logistic模型的Logit变换等值法