Acoustically evoked brain stem potential in Wilson disease

By 48 patients with Wilson's disease the brainstem acoustic evoked potentials were stated. There were 35 pathological findings (73%), 13 were normal (27%). The waves, determined by the middle and upper brainstem (Pons and Mesencephalon) showed most of all pathological changes. Those patients with forms of Wilson's disease called Pseudoskelerose and Pseudoparkinson showed the most pathological findings. But one could watch these findings by about 30% of patients in preclinical stage. This method can possibly be used for early detection of disorders of brainstem functions and in the same way it can be used for control of treatment by patients in preclinical stage.     

Smoking and pain--a method of limits and sensory decision theory analysis

The effects of tobacco smoking on responses to electrical stimulation were studied according to a Method of Limits (ML) threshold analysis and a Sensory Decision Theory (SDT) analysis. For the ML procedure, Detection Threshold (DT), Pain Threshold (PT) and Tolerance Level (TL) measures were obtained. For the SDT procedure, nonparametric estimates of capacity to discriminate between stimulus intensities (P(A)) and response criterion (B) were calculated. There was no main effect of tobacco smoking on responses to electrical stimulation. Males had consistently higher ML thresholds than females in both the NS and S condition. Males also tended to increase in DT and PT after smoking. From a comparison between the effects of smoking on ML and SDT measures it was suggested that PT is related mainly to sensory factors and TL to response factors.     

Constrained classification: The use of a priori information in cluster analysis

In many classification problems, one often possesses external and/or internal information concerning the objects or units to be analyzed which makes it appropriate to impose constraints on the set of allowable classifications and their characteristics. CONCLUS, or CONstrained CLUStering, is a new methodology devised to perform constrained classification in either an overlapping or nonoverlapping (hierarchical or nonhierarchial) manner. This paper initially reviews the related classification literature. A discussion of the use of constraints in clustering problems is then presented. The CONCLUS model and algorithm are described in detail, as well as their flexibility for use in various applications. Monte Carlo results are presented for two synthetic data sets with appropriate discussion of the resulting implications. An illustration of CONCLUS is presented with respect to a sales territory design problem where the objects classified are various Forbes-500 companies. Finally, the discussion section highlights the main contribution of the paper and offers some areas for future research.We wish to thank C. Mallows and J. D. Carroll for some helpful technical discussion and L. Clark and D. Art for their valuable computer assistance. We also wish to thank H. Pollak, R. Gnanadesikan, and J. Kettenring for their thorough reviews of a previous draft of this paper. Finally, we acknowledge helpful comments of the editor and two anonymous reviewers.     

The St. Pauls' riot: An explanation of the limits of crowd action in terms of a social identity model

The paper contains a detailed study of the St. Pauls' riots of April 1980. Particular attention is paid to the limits of participation in the event and the limits of crowd action. It is argued that these limits show clear social form and cannot be explained in terms of the individualistic theories that dominate crowd psychology. Instead a model of crowd behaviour based on the social identity model is advanced to account for the observations. It is concluded that crowd behaviour is more sophisticated and creative than hitherto allowed and that the neglect of this field should be remedied.     

Influence of prolonged deprivation,age and culture on the development of future orientation

Prolonged deprivation and future orientation (FO) were studied in 200 Indian and Nepalese students of 14–16 and 18–20 years with verbal measures. In both cultures low deprived subjects were significantly more future-oriented. In the development of FO both age and deprivation were significant with experiential aspect of socialization exerting greater influence than physico-economic deprivation.     

Acoustic and semantic similarity effects on repetition avoidance in produced sequences

The question of whether repetition avoidance in sequential response production depends on the phonetic or the semantic encoding of previous responses was investigated by varying the acoustic and semantic similarity among the response alternatives. The results indicated that acoustic similarity affected repetition avoidance with six alternative words and a production rate of one per second, but not with four alternative letters and a rate of one per 2 sac. Semantic similarity between words was also studied, and was not seen to affect repetition avoidance. Results were explained by means of a model in which comparisons between a memory set of admissible responses and a memory set of recent responses are made at a phonetic level of response representation.     

Mental extrapolation in patterns constructed from memory

Finke and Pinker (1982, 1983) showed subjects an array of dots followed by an arrow in a blank field, and asked them to determine whether the arrow pointed to any of the previously seen dots. Response times were linearly related to the distance between the arrow and the nearest dot, suggesting that subjects spontaneously used an internal scanning or extrapolation process to perform the task. We replicate and extend this finding by varying the retention interval, and by employing a paradigm in which subjects’ eyes are closed and the arrows are described to them using a coordinate scheme. We also show that subjects are unable to predict the form of the data when the task simply is described to them. Results suggest that mental scanning along a straight path can be performed on images reconstructed from memory, and that it does not depend on the ongoing perception of a continuous surface, on physical eye movements, or on demand characteristics.     

Centering culture in the treatment of opioid use disorder with American Indian and Alaska Native Communities: Contributions from a National Collaborative Board

American Indian/Alaska Native (AI/AN) communities are disproportionally impacted by the opioid overdose epidemic. There remains a dearth of research evaluating methods for effectively implementing treatments for opioid use disorder (OUD) within these communities. We describe proceedings from a 2-day Collaborative Board (CB) meeting tasked with developing an implementation intervention for AI/AN clinical programs to improve the delivery of medications to treat OUD (MOUD). The CB was comprised of Elders, cultural leaders, providers, individuals with lived experience with OUD, and researchers from over 25 communities, organizations, and academic institutions. Conversations were audio-recorded, transcribed, and coded by two academic researchers with interpretation oversight provided by the CB. These proceedings provided a foundation for ongoing CB work and a frame for developing the program-level implementation intervention using a strength-based and holistic model of OUD recovery and wellbeing. Topics of discussion posed to the CB included engagement and recovery strategies, integration of extended family traditions, and addressing stigma and building trust with providers and clients. Integration of traditional healing practices, ceremonies, and other cultural practices was recommended. The importance of centering AI/AN culture and involving family were highlighted as priorities for the intervention.