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121.
In order to test the possible effectiveness of peripheral interventions with the adrenergic system for the alleviation of certain disorders that typically follow bilateral hippocampal lesions, rats with bilateral lesions of the hippocampus, the overlying neocortex, or sham operations were tested at two postoperative times in the Morris water maze, a frequently used "spatial task." Half of the animals in all groups were exposed to the adrenergic manipulations, i.e., a chronic, 7-day, systemic bretylium regime (5 mg/kg) and, in addition, a peripheral injection of norepinephrine (4 micrograms/kg) 30 min before the start of each training day. The other half received saline chronically and a single saline injection before each training day. Five days of training were given at each of the two training periods. The first began 7 days after surgery while the second began 33 days after surgery. As expected, the hippocampally lesioned animals were severely impaired in the task. The adrenergic treatment produced enhanced performances in the rats with hippocampal lesions at both training sessions, although the improvement was greatest at the later period. Although the animals receiving the pharmacologic treatment located the general area of the hidden platform better than the saline-treated animals with hippocampal lesions, the treated animals were still impaired, swimming directly to the hidden platform on fewer trials than did animals in the other groups.  相似文献   
122.
The current study examined the relation between perceiving a calling, living a calling, and job satisfaction among a diverse group of employed adults who completed an online survey (N = 201). Perceiving a calling and living a calling were positively correlated with career commitment, work meaning, and job satisfaction. Living a calling moderated the relations of perceiving a calling with career commitment and work meaning, such that these relations were more robust for those with a stronger sense they were living their calling. Additionally, a moderated, multiple mediator model was run to examine the mediating role of career commitment and work meaning in the relation of perceiving a calling and job satisfaction, while accounting for the moderating role of living a calling. Results indicated that work meaning and career commitment fully mediated the relation between perceiving a calling and job satisfaction. However, the indirect effects of work meaning and career commitment were only significant for individuals with high levels of living a calling, indicating the importance of living a calling in the link between perceiving a calling and job satisfaction. Implications for research and practice are discussed.  相似文献   
123.
Duchenne/Becker muscular dystrophy (DBMD) and spinal muscular atrophy (SMA) are rare neuromuscular disorders that present challenges to therapeutic and clinical trial decision making. We developed an interactive, evidence-based online tool designed to encourage thoughtful deliberation of the pros and cons of trial participation and to inform meaningful discussions with healthcare providers. Prior research demonstrates the importance of tool availability at the time each family is considering trial participation, which may be prior to the informed consent process. The tool is intended to be easily modified to other pediatric disease communities. Tool development was informed by prior qualitative research, literature reviews, and stakeholder input. Specific items were derived based on an online exploratory questionnaire of parents whose children participated in a trial for DBMD or SMA to understand motivations for participation. Parent participants in the exploratory survey reported strong impact of altruistic and individual benefit motivations and placed much greater emphasis on anticipated trial benefits than on harms when making participation decisions. We used this data to develop the evidence-based deliberation tool using a community-engaged approach. We initially targeted the tool for DBMD while using SMA survey data to evaluate ease of transition to that population. We conducted two iterative sets of activities to inform development and refinement of the tool: (1) community engagement of key stakeholders and (2) user experience testing. These activities suggest that the tool may increase deliberation and the weighing of benefits and harms. Ongoing evaluation will determine the acceptability and efficacy of this online intervention.  相似文献   
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125.
Individual differences in self-control have been shown to reflect two underlying dimensions: initiation and inhibition. We examined the possibility that degrees of self-control might likewise be modeled at a broader social level, similar to other socio-cultural differences that operate at an individual level (e.g., collectivism). To test this notion, we used a variety of mundane behaviors measured at the level of U.S. states to create inhibitory and initiatory indices of self-control at a collective level. We show that statewide levels of initiatory and inhibitory self-control, despite being correlated with one another, exhibit unique patterns of association with a wide range of outcomes, including homicide, suicide, home foreclosures, divorce, and infidelity. This study represents one of the first attempts to model the dimensional structure of self-control at a social level and supports the utility of conceptualizing self-control as an important socio-cultural variable.  相似文献   
126.
In recent decades, the amount of text available for organizational science research has grown tremendously. Despite the availability of text and advances in text analysis methods, many of these techniques remain largely segmented by discipline. Moreover, there is an increasing number of open-source tools (R, Python) for text analysis, yet these tools are not easily taken advantage of by social science researchers who likely have limited programming knowledge and exposure to computational methods. In this article, we compare quantitative and qualitative text analysis methods used across social sciences. We describe basic terminology and the overlooked, but critically important, steps in pre-processing raw text (e.g., selection of stop words; stemming). Next, we provide an exploratory analysis of open-ended responses from a prototypical survey dataset using topic modeling with R. We provide a list of best practice recommendations for text analysis focused on (1) hypothesis and question formation, (2) design and data collection, (3) data pre-processing, and (4) topic modeling. We also discuss the creation of scale scores for more traditional correlation and regression analyses. All the data are available in an online repository for the interested reader to practice with, along with a reference list for additional reading, an R markdown file, and an open source interactive topic model tool (topicApp; see https://github.com/wesslen/topicApp, https://github.com/wesslen/text-analysis-org-science, https://dataverse.unc.edu/dataset.xhtml?persistentId=doi:10.15139/S3/R4W7ZS).  相似文献   
127.
In two experiments, learners studied word pairs one or two times and took a final cued recall test. They studied each pair upon its initial presentation and decided whether they would restudy it later, take a practice test on it later (retrieval practice), or forego all further practice with the pair. Whether learners preferred restudying or testing depended upon conditions. Regardless of whether practice tests were followed by feedback, they chose to take practice tests relatively more often when items were easy and the lag or spacing interval between the first and second occurrence was short, whereas they chose to restudy relatively more when items were hard and the lag was long. That is, they preferred testing under conditions in which successful retrieval on the practice test was likely. In Experiment 2, we varied the number of points each item was worth if recalled on the final test. A high point value led to a marked increase in both the preference for testing when the lag was short and the preference for restudying when the lag was long. Results support the hypothesis that learners appreciate at some level that retrieval practice can be a more effective learning strategy than restudying. However, they appear to believe that successful retrieval is necessary to reap the benefits of retrieval practice. As a consequence, their tendency to choose testing is influenced by conditions (item difficulty and spacing interval) that affect the likelihood of successful practice-test retrieval.  相似文献   
128.
This paper argues that there is significant motivation for contemporary ethicists to affirm a view I call “moral property eliminativism.” On this eliminativist view, there are no moral properties, but there are moral truths that are made true by only nonmoral entities. Moral property eliminativism parallels eliminativist views defended in other domains of philosophical inquiry, but has gone nearly entirely overlooked by contemporary ethicists. I argue that moral property eliminativism is motivated by the claim that there cannot be differences in moral truths without differences in nonmoral ontology—a claim widely endorsed by contemporary ethicists. Engaging with a variety of ways whereby one might resist the motivation I cite for moral property eliminativism, I argue that alternative contemporary metaethical views tend to purchase moral properties at the price of unnecessary theoretical complexity.  相似文献   
129.
Mobile internet testing (MIT) is the latest cost effective technological push in employment testing. The ability to access assessments via the internet using mobile devices provides increased speed and convenience for both administrators and respondents. In this article, we examine the equivalence of MIT compared with testing on personal computers (PCs) and whether attitudes and other individual differences influence responses and reactions to MIT. Results demonstrated equivalence for a supervisory situational judgment test across testing modes, but not for a cognitive ability test. Significant relationships were found between anxiety and both performance and reactions to mobile assessment. Respondents also reported significantly more positive reactions when tested on a PC versus a mobile device. Future research and practical implications are discussed.  相似文献   
130.
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