Impaired, spared, and enhanced ACh efflux across the hippocampus and striatum in diencephalic amnesia is dependent on task demands

Diencephalic amnesia manifests itself through a host of neurological and memory impairments. A commonly employed animal model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), results in brain lesions and impairments similar in nature and distribution to those observed in humans with Wernicke–Korsakoff syndrome (WKS). In the current investigation, 2 separate experiments were conducted in which acetylcholine (ACh) efflux was assessed in the hippocampus and striatum of PTD-treated and pair-fed (PF) control male Sprague–Dawley rats. The goal was to determine under what behavioral conditions and in which brain structures ACh efflux was spared, impaired, or adaptively enhanced. In Experiment 1, rats were assessed on a spontaneous alternation task; in Experiment 2, rats were tested on a T-maze discrimination task that could be learned via a hippocampal- or striatal-based strategy. In Experiment 1, PTD-treated rats were impaired on the spontaneous alternation task and ACh efflux in the hippocampus during testing was significantly reduced, but spared in the striatum. In Experiment 2, PTD- and PF-treated rats did not differ in the number of trials to criterion, but PTD-treated rats demonstrated greater reliance upon egocentric cues to solve the task. Furthermore, ACh efflux in the striatum was greater during maze learning in the PTD-treated animals when compared to the PF animals. These results suggest that there is behavioral and systems level plasticity that can facilitate the use of alternative strategies to solve a task following diencephalic damage and WKS.     

Macromolecular synthesis, distributed synaptic plasticity, and fear conditioning

Recent work from a number of laboratories has provided new and important insights about how gene expression is altered by experience and how these molecular changes may provide a substrate for the long-term storage of new memories. Here, we review a series of recent studies using aversive Pavlovian conditioning in rats as a well characterized model system in which experience-dependent alterations in gene expression can be manipulated and quantified within a specific neural circuit. We highlight some of the issues involved in using broad-spectrum inhibitors of mRNA and protein synthesis to study cellular changes underlying the formation and long-term stability of memory and discuss the idea that these changes occur over widespread, behaviorally-defined, networks of cells. We also discuss the idea that the maintenance of memory and its susceptibly to disruption after retrieval may relate to local protein synthesis in dendrites. Finally, a series of recent experiments from our laboratory studying the role of a specific signaling pathway (mTOR) which regulates translational processes and memory formation in the amygdala and hippocampus during fear conditioning are reviewed.     

Do government brochures affect physical activity cognition? A pilot study of Canada's physical activity guide to healthy active living

Health Canada has published national physical activity (PA) guidelines, which are included in their 26-page Physical Activity Guide to Healthy Active Living (CPAG). To date, the use of CPAG as a motivational instrument for PA promotion has not been evaluated. The purpose of this study was to determine whether reading CPAG 1) increased motivational antecedents to engage in regular PA, and 2) increased regular PA intention and behaviour over 1 month. Participants included 130 randomly sampled Canadian adults (18 years or older) who were randomly mailed pack ages consisting of either 1) a questionnaire and a copy of CPAG, or 2) a questionnaire. Questionnaire items pertained to participants' sociodemographics, previous PA behaviours (Godin Leisure-Time Questionnaire) and PA motivation (theory of planned behaviour). Participants were then sent a follow-up questionnaire pertaining to their PA behaviours throughout the previous month. Results revealed significant interactions between the guide condition and previous activity status on instrumental behavioural beliefs about strength activities and subjective norms about endurance activities (p < 0.05), but all other factors were not significantly different. It was concluded that among previously inactive people, receiving this guide may change some informational/motivational constructs, but key motivational antecedents (affective attitude, perceived behavioural control) and outcomes (intention, behaviour) seem unaffected.     

Hedonia, eudaimonia, and well-being: an introduction

Research on well-being can be thought of as falling into two traditions. In one—the hedonistic tradition—the focus is on happiness, generally defined as the presence of positive affect and the absence of negative affect. In the other—the eudaimonic tradition—the focus is on living life in a full and deeply satisfying way. Recognizing that much recent research on well-being has been more closely aligned with the hedonistic tradition, this special issue presents discussions and research reviews from the eudaimonic tradition, making clear how the concept of eudaimonia adds an important perspective to our understanding of well-being.     

COMPARISON OF DATA‐COLLECTION METHODS IN A BEHAVIORAL INTERVENTION PROGRAM FOR CHILDREN WITH PERVASIVE DEVELOPMENTAL DISORDERS: A REPLICATION

Cummings and Carr (2009) compared two methods of data collection in a behavioral intervention program for children with pervasive developmental disorders: collecting data on all trials versus only the first trial in a session. Results showed that basing a child's progress on first‐trial data resulted in identifying mastery‐level responding slightly sooner, whereas determining mastery based on all trials resulted in slightly better skill maintenance. In the current replication, no such differences in indication of mastery or maintenance were observed when data were collected on all trials or the first trial.     

Politics, schadenfreude, and ingroup identification: The sometimes happy thing about a poor economy and death

Political campaigns are often characterized by the various events occurring that move the tide in favor of one candidate or another. Each event, depending on which candidate it favors or harms, produces either happiness or sadness for those who care about the outcome. This research examined whether such reactions would hold for events that are misfortunes for other people and even when they negatively affect society more broadly regardless of political party affiliation. Ingroup (i.e. political party) identification was examined as an important moderating variable. In four studies, undergraduate participants gave their emotional reactions to news articles describing misfortunes happening to others (e.g. poor economic news and house foreclosures). Party affiliation and the intensity of ingroup identification strongly predicted whether these events produced schadenfreude.     

The Problem of Patriotism: A Psychoanalytic and Theological Analysis

In this article, I examine patriotism from psychoanalytic and theological perspectives, arguing that it is a deeply problematic form of love and devotion. After providing a brief overview of the discourse vis-à-vis patriotism, I depict the characteristics of a dominant form of patriotism (self-state) in the U.S. Given this, I argue that, while patriotism has a variety of forms, the most prevalent form tends toward tragic consequences and it is this tragic tendency that I depict from psychoanalytic and theological perspectives. From a psychoanalytic perspective, the extant form of patriotism in the U.S. represents a self-state that signifies an idealized, omnipotent, and imaginary identification, which is accompanied by and contingent upon a devaluation of the Other. Moreover, the dominant form of patriotic self-states is secured by weak dissociation, omnipotent thinking and, in most cases, a collapse of the symbolic equation. From a Christian theological perspective, patriotism signifies absolutizing the relative and contingent. This form of idolatry manifests a distortion of reason and will, which contributes to corrupted and corrupting forms of love and devotion.     

School Violence and the Culture of Honor

ABSTRACT— We investigated the hypothesis that a sociocultural variable known as the culture of honor would be uniquely predictive of school-violence indicators. Controlling for demographic characteristics associated in previous studies with violent crime among adults, we found that high-school students in culture-of-honor states were significantly more likely than high-school students in non-culture-of-honor states to report having brought a weapon to school in the past month. Using data aggregated over a 20-year period, we also found that culture-of-honor states had more than twice as many school shootings per capita as non-culture-of-honor states. The data revealed important differences between school violence and general patterns of homicide and are consistent with the view that many acts of school violence reflect retaliatory aggression springing from intensely experienced social-identity threats.     

The Effect of Mindfulness on Heart Rate Control

An experiment was conducted to test the hypothesis that mindful attention to change regarding heart rate (HR) would result in greater control over HR. Experimental groups monitored the changing or stable nature of HR, respectively. All participants’ HR slowed during the decrease phase. Participants whose attention was directed to the stable nature of HR performed the worst on the increase phase of the HR control task. These results suggest that mindfulness, instantiated here as attention to variability, is a means to increasing control.

Eyewitness identification evidence and innocence risk

It is well known that the frailties of human memory and vulnerability to suggestion lead to eyewitness identification errors. However, variations in different aspects of the eyewitnessing conditions produce different kinds of errors that are related to wrongful convictions in very different ways. We present a review of the eyewitness identification literature, organized around underlying cognitive mechanisms, memory, similarity, and decision processes, assessing the effects on both correct and mistaken identification. In addition, we calculate a conditional probability we call innocence risk, which is the probability that the suspect is innocent, given that the suspect was identified. Assessment of innocence risk is critical to the theoretical development of eyewitness identification research, as well as to legal decision making and policy evaluation. Our review shows a complex relationship between misidentification and innocence risk, sheds light on some areas of controversy, and suggests that some issues thought to be resolved are in need of additional research.