Cancer Risk Assessment Using Genetic Panel Testing: Considerations for Clinical Application

With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines.     

If I imagine it,then it happened: The Implicit Truth Value of imaginary representations

Imagination sometimes leads people to behave, feel, and think as though imagined events were real even when they know they were not. In this paper, we suggest that some understanding of these phenomena can be achieved by differentiating between Implicit Truth Value (ITV), a spontaneous truth evaluation, and Explicit Truth Value (ETV), a self-reported truth judgment. In three experiments, we measure ITV using the autobiographical Implicit Association Test (Sartori, Agosta, Zogmaister, Ferrara, & Castiello, 2008), which has been used to assess which of two autobiographical events is true. Our findings demonstrate that imagining an event, like experiencing an event, increases its ITV, even when people explicitly acknowledge the imagined event as false (Experiments 1a and 1b). Furthermore, we show that imagined representations generated from a first-person perspective have higher ITV than imagined representations generated from a third-person perspective (Experiment 2). Our findings suggest that implicit and explicit measures of truth differ in their sensitivity to properties underlying truth judgment. We discuss the contribution of characterizing events according to both ITV and ETV to the understanding of various psychological phenomena, such as lying and self-deception.     

A Normative Database and Determinants of Lexical Retrieval for 186 Arabic Nouns: Effects of Psycholinguistic and Morpho-Syntactic Variables on Naming Latency

Research into lexical retrieval requires pictorial stimuli standardised for key psycholinguistic variables. Such databases exist in a number of languages but not in Arabic. In addition there are few studies of the effects of psycholinguistic and morpho-syntactic variables on Arabic lexical retrieval. The current study identified a set of culturally and linguistically appropriate concept labels, and corresponding photographic representations for Levantine Arabic. The set included masculine and feminine nouns, nouns from both types of plural formation (sound and broken), and both rational and irrational nouns. Levantine Arabic speakers provided norms for visual complexity, imageability, age of acquisition, naming latency and name agreement. This delivered a normative database for a set of 186 Arabic nouns. The effects of the morpho-syntactic and the psycholinguistic variables on lexical retrieval were explored using the database. Imageability and age of acquisition were the only significant determinants of successful lexical retrieval in Arabic. None of the other variables, including all the linguistic variables, had any effect on production time. The normative database is available for the use of clinicians and researchers in the Arab world in the domains of speech and language pathology, neurolinguistics and psycholinguistics. The database and the photographic representations will be soon available for free download from the first author’s personal webpage or via email.     

Longitudinal Analysis of Adolescent NSSI: The Role of Intrapersonal and Interpersonal Factors

Non-suicidal self-injury (NSSI) occurs in approximately 10 % of adolescents. To establish effective prevention and intervention initiatives, it is important to understand onset, maintenance and cessation of NSSI. We explored whether the relationships between interpersonal factors (i.e. attachment, social support) and NSSI were mediated by intrapersonal factors (i.e. emotion regulation, self-esteem, self-efficacy). Participants were 1973 students (1414 female and 559 male) aged between 12 and 18 years (M?=?13.89, SD?=?0.97) recruited from 40 Australian high schools. Participants completed a questionnaire at two time-points with a 12-month interval. At baseline, 8.3 % of adolescents engaged in NSSI, increasing to 11.9 % at follow-up. Family support was most salient in onset, maintenance and cessation of NSSI. Attachment anxiety was related to NSSI onset. Of the intrapersonal variables, self-esteem and self-efficacy were significant in predicting onset of NSSI. Self-esteem, self-efficacy and cognitive reappraisal mediated the relationship between attachment anxiety and NSSI onset. A combination of interpersonal and intrapersonal variables contributes to the onset, maintenance and cessation of NSSI in adolescence. Perceived family support appears to be an important safeguard against NSSI. Strategies targeting family functioning and teaching cognitive reappraisal techniques to adolescents may reduce the number engaging in NSSI.     

“There is Something not Quite Right with Brad…”: The Ways in Which Families Construct ADHD Before Receiving a Diagnosis

This study explored how four families who were in the midst of the process of a potential diagnosis of ‘Attention Deficit Hyperactivity Disorder’ (ADHD) for their child negotiated competing explanations of the problems. The research drew on a social constructionist, systemic and attachment lens to understand; (a) the constellations of meanings that are constructed by the families to explain the difficulties and (b) how families use strategies in their talk to account for or contest these constellations of meaning. A discursive analysis revealed that the families in this study, following initial explorations, adopted a sequential and cumulative dismissal of psychosocial explanations. Hence, the thrust of the conversation implicitly added up to the only possibility, the inevitable conclusion that it was ADHD. The malleability and flexibility in which the families explored these explanations varied and for some families the process of closure towards ‘illness’ as a dominant explanation sealed alternative conversations more than in others. The findings also revealed a complexity for the parents in balancing the need to offer discipline versus another response and this has clinical implications and highlights the need for further research in this area.     

Can learning about the Holocaust be spiritual? Reflections on a teaching and learning experience with Primary School children.

In April 2017, I spent a week in Poland researching the Holocaust in Europe. Most notably, I visited the Auschwitz and Birkenau concentration camps. Following the visit, I facilitated three History lessons with 10- and 11-year-old children on the role of Auschwitz in the Second World War. As the sessions unfolded, the spiritual themes of meaning, identity and remembering emerged from the children’s responses; therefore, this article forms a reflection on how the lessons impacted the children’s spiritual lives. It also considers how the History curriculum might include a critical dimension to pedagogy. In particular, it explores how issues such as theology, morality and the role of representation open up a space for critical questioning. I suggest that such questioning is also spiritual. Thus, the self-awareness and criticality inspired might contribute to transformation – of both the teachers and learners and the world around them.     

Inferences from disclosures about the truth and falsity of expert testimony

Participants acting as mock jurors made inferences about whether a person was a suspect in a murder based on an expert's testimony about the presence of objects at the crime scene and the disclosure that the testimony was true or false. Experiment 1 showed that participants made more correct inferences, and made inferences more quickly, when the truth or falsity of the expert's testimony was disclosed immediately after the testimony rather than when the disclosure was delayed. Experiment 2 showed no advantage for prior disclosure over immediate disclosure. Experiment 3 showed that the pattern of inferences when there was no disclosure mirrored the pattern when it was disclosed that the expert's testimony was true rather than false. Participants made more correct inferences from true conjunctions than disjunctions, and from false disjunctions than conjunctions. We discuss the implications for theories of the mental representations and cognitive processes that underlie human reasoning.     

Why Frankenstein is a Stigma Among Scientists

As one of the best known science narratives about the consequences of creating life, Mary Shelley’s Frankenstein; or, The Modern Prometheus (1818) is an enduring tale that people know and understand with an almost instinctive familiarity. It has become a myth reflecting people’s ambivalent feelings about emerging science: they are curious about science, but they are also afraid of what science can do to them. In this essay, we argue that the Frankenstein myth has evolved into a stigma attached to scientists that focalizes the public’s as well as the scientific community’s negative reactions towards certain sciences and scientific practices. This stigma produces ambivalent reactions towards scientific artifacts and it leads to negative connotations because it implies that some sciences are dangerous and harmful. We argue that understanding the Frankenstein stigma can empower scientists by helping them revisit their own biases as well as responding effectively to people’s expectations for, and attitudes towards, scientists and scientific artifacts. Debunking the Frankenstein stigma could also allow scientists to reshape their professional identities so they can better show the public what ethical and moral values guide their research enterprises.