Monozygotic twins with Asperger syndrome: differences in behaviour reflect variations in brain structure and function

A pair of monozygotic twins discordant for symptoms of Asperger syndrome was evaluated at the age of 13.45 years using psychometric, morphometric, behavioural, and functional imaging methods. The lower-functioning twin had a smaller brain overall, a smaller right cerebellum, and a disproportionately large left frontal lobe, and manifested almost no differential activation between distractors of high and low-congruence with target visual stimuli. The higher-functioning twin manifested a typically autistic pattern of anterior deactivation and posterior hyperactivation in response to incongruent distractors, overlaid with a typically normal pattern of activation of superior frontal cortex. The morphometric results are consistent with known correlations between brain structure and behaviour in autism, and the physiological results suggest correspondences between structure and function.     

Adherence to HAART: perspectives from clients in treatment support programs

The development of highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and mortality for HIV-infected individuals. Because the long-term efficacy of HAART is dependent on near perfect adherence, many providers offer services to support adherence, including education, regimen review, counseling, and reminder tools. Little is known regarding the utilization or efficacy of these services. In this paper, we report on data collected during 32 open-ended interviews conducted with individuals receiving services through the New York State Treatment Adherence Demonstration Project. Participants in the project reported deriving benefits from a broad range of project activities. Educational efforts helped clients to recognize HIV as a manageable, rather than terminal, illness. Information and tools focused on specific regimens provided clients with concrete knowledge and skills. Effective communication with medical providers and pharmacists was facilitated by adherence staff who proactively advocated for client needs. Program-based social support was particularly valuable for many participants, helping them to retain needed motivation and strength. Educational, practical, and supportive services were all considered valuable to clients participating in adherence support programs. A mix of services may best meet the range of needs found among persons taking HAART.     

Parent-infant synchrony and the social-emotional development of triplets

To study the social-emotional development of triplets, 23 sets of triplets, 23 sets of twins, and 23 singleton infants (N=138) were followed from birth to 2 years. Maternal depression and social support were assessed in the postpartum period, mother-infant and father-infant interaction and the home environment were observed at 3 months, a separation-reunion episode and a maternal interview were conducted at 12 months, and infant behavior problems were evaluated at 24 months. Lower parent-infant synchrony was observed for triplets. Triplets showed less distress during maternal separation and less approach at reunion. Mothers reported lower adjustment and differentiation among siblings for triplets than for twins. Higher internalizing problems were reported for triplets, and the triplet with intrauterine growth retardation showed the poorest outcomes. Behavior problems were predicted by medical risk, maternal depression, parent-infant synchrony, infant approach, and mother adjustment. Discussion focuses on developmental risk when the exclusivity of the parent-infant relationship is compromised.     

Effects of preshift small magnitude of reward received during goalbox placements on the negative contrast effect

During preshift, one experimental group of rats was given a large magnitude of food reward following a traversal of a straight alley and during a goalbox placement, while the other experimental group was given a small reward during goalbox placement and a large reward following a run. During postshift, all experimental groups were given a small reward of food following a traversal down the runway and during a goalbox placement. A control group was maintained on small reward during placements and following a traversal throughout the study. Only the group who received preshift large reward during placement and following a runway response ran slower to small reward during postshift than the control group maintained on small reward (negative contrast effect).     

Speechreading skill and visual movement sensitivity are related in deaf speechreaders

Individual speechreading abilities have been linked with a range of cognitive and language-processing factors. The role of specifically visual abilities in relation to the processing of visible speech is less studied. Here we report that the detection of coherent visible motion in random-dot kinematogram displays is related to speechreading skill in deaf, but not in hearing, speechreaders. A control task requiring the detection of visual form showed no such relationship. Additionally, people born deaf were better speechreaders than hearing people on a new test of silent speechreading.     

Social risk and protective factors for suicide attempts in low income African American men and women

A case-control study was conducted to examine a broad array of potential social risk and protective factors for suicide attempt among 200 African American men and women receiving care at a large, public, urban hospital. Specifically, we examined the effect of the following potential risk factors for suicide attempt: life hassles, partner abuse, partner dissatisfaction, and racist events; as well as the following potential protective factors: effectiveness of obtaining resources, social embeddedness, and social support. Using logistic regression, suicide attempter status was predicted by two independently significant social variables: one risk factor (life hassles) and one protective factor (social support). Male versus female suicide attempters were not distinguished by the social variables. These findings, which support the utility of an ecological conceptualization of risk and protective factors for suicide attempt, help to clarify the independently significant social environment risk and protective factors for suicide attempts among economically disadvantaged African Americans in particular. Research on both risk factors and protective factors provide a basis for culturally competent interventions aimed at reducing both the risk of future suicide attempts and completions.     

Involvement and role of the hypothalamo-pituitary-adrenal (HPA) stress axis in animal models of chronic pain and inflammation

Hypothalamo-pituitary-adrenal (HPA) axis changes have been reported in several disease states, including major depressive disorder, rheumatoid arthritis, multiple sclerosis and various other conditions associated with chronic pain. These observations suggest that stress and the HPA axis may play important roles in the pathology of these diseases. In order to contribute to a better understanding of the role that chronic stress may play in human pathology, this review article explores the involvement of the HPA axis in those animal models of chronic pain and inflammation that entail persistent rather than intermittent stress.     

The Beck effect is back,now in color: A demonstration

It has been repeatedly found (e.g., Beck, 1982; Beck & Ambler, 1973) that a tilted T is detected better than an L when presented on the background of a number of upright Ts, although in isolation both are discriminated from an upright T about equally well. We demonstrate that an analogous interaction between context presence and stimulus type can be obtained with color stimuli: A light green was discriminated from a dark green better than an olive brown was, yet that occurred only in the context of a background of three dark green disks. This indicates that the effects, both original and novel, probably are not due to anything peculiar to form perception, such as line arrangement or supraelement configurations. It is suggested that the presence of collateral background stimuli probably enables the perceptual system to capitalize on relative judgment involving contrasts or deviations from a presented anchor value.     

Perceptual grouping and attention: Not all groupings are equal

We examined grouping under inattention using Driver, Davis, Russell, Turatto, & Freeman’s (2001) method. On each trial, two successive displays were briefly presented, each comprising a central target square surrounded by elements. The task was to judge whether the two targets were the same or different. The organization of the background elements stayed the same or changed, independently of the targets. In different conditions, background elements grouped into columns/rows by color similarity, a shape (a triangle/arrow, a square/cross, or a vertical/horizontal line) by color similarity, and a shape with no other elements in the background. We measured the influence of the background on the target same-different judgments. The results imply that background elements grouped into columns/rows by color similarity and into a shape when no segregation from other elements was involved and the shape was relatively “good.” In contrast, no background grouping was observed when resolving figure-ground relations for segregated units was required, as in grouping into a shape by color similarity. These results suggest that grouping is a multiplicity of processes that vary in their attentional demands. Regardless of attentional demands, the products of grouping are not available to awareness without attention.