Genetic Counselors’ Perspectives About Cell-Free DNA: Experiences,Challenges, and Expectations for Obstetricians

The expansion of cell-free fetal DNA (cfDNA) screening for a larger and diverse set of genetic variants, in addition for use among the low-risk obstetric population, presents important clinical challenges for all healthcare providers involved in the delivery of prenatal care. It is unclear how to leverage the different members of the healthcare team to respond to these challenges. We conducted interviews with 25 prenatal genetic counselors to understand their experience with the continued expansion of cfDNA screening. Participants supported the use of cfDNA screening for the common autosomal aneuploidies, but noted some reservations for its use to identify fetal sex and microdeletions. Participants reported several barriers to ensuring that patients have the information and support to make informed decisions about using cfDNA to screen for these different conditions. This was seen as a dual-sided problem, and necessitated additional education interventions that addressed patients seeking cfDNA screening, and obstetricians who introduce the concepts of genetic risk and cfDNA to patients. In addition, participants noted that they have a professional responsibility to educate obstetricians about cfDNA so they can be prepared to be gatekeepers of counseling and education about this screening option for use among the general obstetric population.     

Facts and Possibilities: A Model‐Based Theory of Sentential Reasoning

This article presents a fundamental advance in the theory of mental models as an explanation of reasoning about facts, possibilities, and probabilities. It postulates that the meanings of compound assertions, such as conditionals (if) and disjunctions (or), unlike those in logic, refer to conjunctions of epistemic possibilities that hold in default of information to the contrary. Various factors such as general knowledge can modulate these interpretations. New information can always override sentential inferences; that is, reasoning in daily life is defeasible (or nonmonotonic). The theory is a dual process one: It distinguishes between intuitive inferences (based on system 1) and deliberative inferences (based on system 2). The article describes a computer implementation of the theory, including its two systems of reasoning, and it shows how the program simulates crucial predictions that evidence corroborates. It concludes with a discussion of how the theory contrasts with those based on logic or on probabilities.     

Teenagers’ Perceptions of Volunteering Following the 2010–2011 Canterbury Earthquakes,New Zealand

ABSTRACT

Limited research exists of teenagers’ involvement in the response phase of a natural disaster. There is little, for example on volunteering, and of specifically what motivates teenagers to volunteer and the activities they participate in. Therefore, this study investigated teenagers’ involvement and perceptions of volunteering following the 2010–2011 Canterbury, New Zealand, earthquakes. Six focus groups were conducted with 31 teenagers aged 16–18 who had experienced the earthquakes. The data were analyzed using thematic analysis leading to four themes, namely sense of control, sense of purpose, shift in perspective, and restrictions. Findings emphasize the importance of organizing youth-focused volunteer groups, due to volunteering potentially reducing teenagers’ psychological distress postdisaster.     

Dissecting stimulus–response binding effects: Grouping by color separately impacts integration and retrieval processes

In selection tasks, target and distractor features can be encoded together with the response into the same short-lived memory trace, or event file (see Hommel, 2004), leading to bindings between stimulus and response features. The repetition of a stored target or distractor feature can lead to the retrieval of the entire episode, including the response—so-called “binding effects.” Binding effects due to distractor repetition are stronger for grouped than for nongrouped target and distractor stimulus configurations. Modulation of either of two mechanisms that lead to the observed binding effects might be responsible here: Grouping may influence either stimulus–response integration or stimulus–response retrieval. In the present study we investigated the influences of grouping on both mechanisms independently. In two experiments, target and distractor letters were grouped (or nongrouped) via color (dis)similarity separately during integration and retrieval. Grouping by color similarity affected integration and retrieval mechanisms independently and in different ways. Color dissimilarity enhanced distractor-based retrieval, whereas color similarity enhanced distractor integration. We concluded that stimulus grouping is relevant for binding effects, but that the mechanisms that contribute to binding effects should be carefully separated.     

Pygmalion in the genes? On the potentially negative impacts of polygenic scores for educational attainment

Social Psychology of Education - Polygenic scores for educational attainment and related variables, such as IQ and “mathematical ability” are now readily available via...     

Feeling Hopeful Inspires Support for Social Change

Hope is an emotion that has been implicated in social change efforts, yet little research has examined whether feeling hopeful actually motivates support for social change. Study 1 (N = 274) confirmed that hope is associated with greater support for social change in two countries with different political contexts. Study 2 (N = 165) revealed that hope predicts support for social change over and above other emotions often investigated in collective action research. Study 3 (N = 100) replicated this finding using a hope scale and showed the effect occurs independent of positive mood. Study 4 (N = 58) demonstrated experimentally that hope motivates support for social change. In all four studies, the effect of hope was mediated by perceived efficacy to achieve social equality. This research confirms the motivating potential of hope and illustrates the power of this emotion in generating social change.     

Comparing Continuous and Discontinuous Data Collection during Discrete Trial Teaching of Tacting by Children with Autism

The present study compared continuous and discontinuous data collection systems on acquisition, generalization, and maintenance of tacts, and on‐task behavior, during discrete trial teaching with three children with autism. A constant prompt‐delay procedure was used to teach tacts. Performance across data collection systems was compared using continuous measurement collected daily in the presence of teaching, discontinuous measurement of the first trial only, and discontinuous measurement collected weekly in the absence of teaching (i.e., probe data). An adapted alternating treatments design was used. For two of the three participants, tacts were acquired most rapidly in the continuous measurement condition, although the differences were small. For the third participant, no systematic differences were found in skill acquisition across the three data collection systems. For all three participants, minimal to no differences were found across data collection systems with regard to generalization and maintenance of tacting, and on‐task behavior. Additionally, procedural integrity was high and comparable across all data collection procedures. Overall, these results suggest the use of continuous data collection for teaching tacts to children with autism, as it provides the most sensitive measure of change in performance. Copyright © 2016 John Wiley & Sons, Ltd.     

The role of ‘<Emphasis Type="Italic">accompagnement</Emphasis>’ in the end-of-life debate in France: from solidarity to autonomy

This article traces the way autonomy has become a recognised value in health care in France. In a country that based its social fundamentals on the very idea of solidarity for many years, autonomy has long been considered a foreign ‘Anglo-American principle’. Taking the example of the end-of-life debate, the article shows, however, how the use of the French term ‘accompagnement’ allowed autonomy to be redefined and to be associated with the concept of solidarity. Exploring the arguments used over the past 25 years in professional guidelines, parliamentary reports, ethics committee reports, and legal texts, the authors describe the shift that took place in public and legal discourses on end-of-life care. The analysis demonstrates how the scope of autonomy has been limited by other social values, such as the protection of the dying person, in order to become an accepted social value in its own right. The example of the French end-of-life debate shows that depending on how the concept of autonomy is adapted and applied in a specific context, it can be compatible with the idea of solidarity. Such compatibility has been challenged previously in the international bioethics debate. By demonstrating the possibility of combining autonomy and solidarity, this article makes an important contribution to the international bioethics debate and to the dialogue between countries that are often perceived as significantly different.