浅析肿瘤疫苗

肿瘤疫苗作为肿瘤特异性主动免疫治疗的方式,目的是激发启动,调节增强机体固有的免疫功能和抗癌能力以维护机体生理平衡。具有使机体由被动抗癌向主动抗癌转变的特点。     

Describing organizations as reinforcer systems: A new use for job satisfaction and employee attitude surveys

Job satisfaction data on managerial personnel were used to illustrate how organizations can be differentiated and described as reinforcer systems. Twenty-seven specific satisfaction scales were regressed on overall job satisfaction, separately for each of five groups of managers from five organizations. For all groups, overall satisfaction was found to be determined mainly by scales concerning challenge of the job and prospects of one's chosen career. Application of decremental stepwise multiple regression procedures to obtain minimum-variable-set equations resulted in different, though overlapping, sets of variables in the equations for the different organizations. These results suggest a way of describing organizations as reinforcer systems, in terms of the specific determinants of overall satisfaction for the organization.     

Site preference and alloying effect of tungsten in the μ phase of Co7Mo6

The electronic structures of the μ phase of Co₇Mo₆ were investigated by means of first-principles calculation based on the density functional theory. The calculated equilibrium lattice parameters of Co₇Mo₆ are in good agreement with the experimental results. The results of calculation reveal that the addition of tungsten (W) promotes the stability of the μ phase of Co₇Mo₆ and W tends to participate in its formation. Through analysing the calculated electronic structure (partial density of states and charge density difference), it can be noted that a strong interaction exists due to d–d hybridization. Also, the majority of the atoms may contribute their valence electrons to the formation of metallic bonds in binary and ternary systems. Furthermore, the calculated results show that the doped W atom prefers to occupy the Co site in Co₇Mo₆ μ phase.     

科学对“后世”声称的检验（一）

后世存在有证据吗？我们能否与亡者进行沟通？他们的存在是否具有一定的形式呢？是“脱离肉体的灵魂”或是“无实体的精神”？这是个古老的问题,它事关信仰永生和强烈的对不朽的渴望。科学能否调查和揭示那些基于有神论信仰者利益的声明吗？回答是肯定的。科学在尽其所能来回应这些声称时要面对不仅仅是宗教学家们所倡导的灵魂不朽和天堂许诺等内容对人们的深刻影响,还要迎接来自媒体和公众的艰巨的挑战,媒体不断追求轰动效应,庞大的公众群体迷恋于此类现象。     

TOWARD A MENTALISTIC ACCOUNT OF EARLY PSYCHOLOGICAL REASONING

Recent investigations of early psychological understanding have revealed three key findings. First, young infants attribute goals and dispositions to any entity they perceive as an agent, whether human or non-human. Second, when interpreting an agent's actions in a scene, young infants take into account the agent's representation of the scene, even if this representation is less complete than their own. Third, at least by the second year of life, infants recognize that agents can hold false beliefs about a scene. Together, these findings support a system-based, mentalistic account of early psychological reasoning.     

Talking about visually perceived events: Communication effects on eyewitness memory

Communicators' tuning of a message about a social target to their audience's evaluation can shape their representation of the target. This audience‐tuning effect has been demonstrated with ambiguous text passages as input material. We examined whether the effect also occurs when communicators learn about the target's behaviours from visual (nonverbal) input material. In Experiment 1, participants watched a soundless video depicting ambiguous behaviours of a target, described the video to an audience who liked (vs. disliked) the target, and subsequently recalled the video. Both message and recall were biased towards the audience's judgement. In Experiment 2, the video depicted a forensically relevant event, specifically ambiguous behaviours of two persons involved in a bar brawl. Participants tuned their event retellings to their audience's responsibility judgement and remembered the event accordingly. In both experiments, the effect of the audience's judgement on recall was statistically mediated by the extent to which the message was tuned to the audience. The more participants experienced a shared reality with their audience the stronger was the message‐recall correlation (Experiment 2). We conclude that the audience‐tuning effect for visually perceived information depends on the communicators' creation of a shared reality with their audience. Copyright © 2011 John Wiley & Sons, Ltd.     

Psychological strengths and subjective well-being in South African white students

This study investigated the role of individual resources, notably self-efficacy, gratitude, and hope, in subjective well-being of white dormitory students at a historically white institution of higher learning. Using a convenience sample of white students (N?=?227), we tested the role of generalised self-efficacy, gratitude, and hope as indicators of a latent factor, labelled personal resources, in a structural equation model with subjective well-being as the latent output variable, measured by self-esteem and satisfaction with life. Path analyses indicated a reasonable fit between the data and our hypothesised theoretical model which proposed positive relations between levels of generalised self-efficacy, gratitude, dispositional hope, self-esteem and satisfaction with life. White students were psychologically doing well, considering above-midpoint levels obtained for levels of generalised self-efficacy, gratitude, dispositional hope, and satisfaction with life However, scores obtained for self-esteem and adult dispositional hope were below the mid-point and neutral respectively, indicating that White students do not agree that they experience high levels of these two psychological strengths. White female students experienced higher levels of hope, gratitude, and life satisfaction, while no significant gender differences were found for generalised self-efficacy and self-esteem. The results of this study highlight the potential for using psychological strengths to promote well-being in racially diverse students.     

羞怯与受欺负:社交回避与被他人容纳的多重中介效应

采用大学生羞怯量表、被他人容纳量表、大学生社交回避及苦恼量表和欺负问卷测量了369名大学生,探讨社交回避和被他人容纳在羞怯与受欺负之间的作用。结果表明:(1)羞怯、社交回避和受欺负三个变量彼此之间均呈显著正相关,这三个变量与被他人容纳均呈显著负相关;(2)羞怯不仅直接影响受欺负,也通过社交回避-被他人容纳的链式中介作用间接影响受欺负。     

Attenuated audiovisual integration in middle-aged adults in a discrimination task

Numerous studies have focused on the diversity of audiovisual integration between younger and older adults. However, consecutive trends in audiovisual integration throughout life are still unclear. In the present study, to clarify audiovisual integration characteristics in middle-aged adults, we instructed younger and middle-aged adults to conduct an auditory/visual stimuli discrimination experiment. Randomized streams of unimodal auditory (A), unimodal visual (V) or audiovisual stimuli were presented on the left or right hemispace of the central fixation point, and subjects were instructed to respond to the target stimuli rapidly and accurately. Our results demonstrated that the responses of middle-aged adults to all unimodal and bimodal stimuli were significantly slower than those of younger adults (p < 0.05). Audiovisual integration was markedly delayed (onset time 360 ms) and weaker (peak 3.97%) in middle-aged adults than in younger adults (onset time 260 ms, peak 11.86%). The results suggested that audiovisual integration was attenuated in middle-aged adults and further confirmed age-related decline in information processing.