The dorsomedial prefrontal cortex (dmPFC) plays a very important role in decision-related and anxiety-related information processing. It has enriched 5-HT6 receptors; however, the precise role of dmPFC 5-HT6 receptors in anxiety remains to be fully investigated. In this study, we injected dmPFC with the 5-HT6 receptor agonist EMD 386088 and antagonist SB 271046 using stereotactic technology. 5-HT6 receptor activation in mice increased time spent in the center area on the open-field test, increased exploration of the open arms on the elevated plus maze test, and increased ratio on the social interaction test. 5-HT6 receptor inactivation induced the opposite effects. In brain slices, EMD 386088 decreased both spontaneous inhibitory postsynaptic currents (sIPSC) and spontaneous excitatory postsynaptic currents (sEPSC), while SB 271046 only increased sEPSC. These effects of EMD 386088 and SB 271046 could be reversed by the GABAA receptor antagonist bicuculline (BMI) and positive allosteric modulator clonazepam (CLZ), respectively. Our results suggest that neurotransmission in the dmPFC by 5-HT6 receptor activation and inhibition may play an important role in anxiety-like behavior, and may provide new insight into the pathological mechanism and potential target of anxiety disorders. 相似文献
This study examined associations between physical activity and depressive symptoms in 1,151 community-dwelling adults in Japan. Physical activity was measured using a pedometer, whereas depressive symptoms were assessed with the Center for Epidemiological Studies-Depression Scale. A structural equation modeling with a cross-lagged panel design revealed that for the older adults (65-79 years of age), daily walking at baseline predicted fewer depressive symptoms at the 2-year follow-up, even after adjusting for confounders. In contrast, the association was not confirmed for the middle-aged adults (40-64 years of age). Findings suggest that age should be considered when estimating the effect of physical activity on psychological well-being. 相似文献
The COVID-19 pandemic produced multiple stressors that risk relationship conflict and dissatisfaction. We extended prior studies that yielded inconsistent effects of the pandemic on relationships by using propensity score matching to (1) compare levels of relationship conflict and satisfaction during the pandemic (pandemic group; N = 7268) to similar people immediately before the pandemic (matched control group; N = 7268), and (2) compare pandemic groups facing different types of restrictions, beginning with lockdowns involving household isolation to returning to normal life. Results reveal that relationship conflict increased and relationship satisfaction decreased in response to the pandemic, but these effects were very small and primarily occurred in the initial stages of the pandemic when lockdown involved household isolation. The results add to evidence of resilience in personal and relationship well-being in 2020, but also indicate the importance of understanding the effects of varying pandemic-related conditions across the years of the pandemic. 相似文献
Are syntactic representations shared across languages, and how might that inform the nature of syntactic computations? To investigate these issues, we presented French-English bilinguals with mixed-language word sequences for 200 ms and asked them to report the identity of one word at a post-cued location. The words either formed an interpretable grammatical sequence via shared syntax (e.g., ses feet sont big – where the French words ses and sont translate into his and are, respectively) or an ungrammatical sequence with the same words (e.g., sont feet ses big). Word identification was significantly greater in the grammatical sequences – a bilingual sentence superiority effect. These results not only provide support for shared syntax, but also reveal a fascinating ability of bilinguals to simultaneously connect words from their two languages through these shared syntactic representations.
This research investigated how working models of attachment are carried forward from one relationship to the next. A two-part study was conducted in which participants learned about two potential dating partners: one that was constructed to resemble a romantic partner from their past and one that resembled a partner from another participant's past. Results showed that people applied their attachment representations of past partners to both targets but did so to a greater degree when the target resembled a past partner. People also tended to feel more anxious and less avoidant toward the target that resembled their past partner. Overall, the findings were consistent with the hypothesis that working models of attachment are transferred in both general and selective ways in new relationships. 相似文献