Orbitofrontal cortex and dynamic filtering of emotional stimuli

Event-related potentials (ER) were recorded in response to mildly aversive somatosensory and auditory stimuli. Patients with orbitofrontal lesions exhited enhanced ERPs (i.e., P3 amplitudes), as compared with control subjects. Moreover, these patients did not habituate to somatoensory stimuli across blocks of trials. The results were specific to orbitofrontal damage, since patients with damage to the dorsolateral prefontal cortex did not exhibit enhanced P3 amplitudes. These findings suggest damage to the orbitofrontal cortex impairs the ability to modulate or inhibit neural responses to aversive stimuli. The findings are couched in terms of dynamic filtering theory, which suggests that the orbitofrontal cortex is involved in the selection and active inhibition of neural circuits associated with emotional responses.     

合理用药中用药时间的研究

为了研究用药时间、用药间隔、停药时间对合理用药的影响,确定用药的最佳时间、最佳间隔,以达到高效低毒的效果,为临床合理用药提供依据。以“时辰药理学”理论为依托,阐述时间因素对药物在体内的吸收、分布、代谢、排泄的影响。因此,时间是合理用药最重要因素之一,在用药过程中,我们应将时间和剂量看成同等重要。     

First Impressions of the Face: Predicting Success

The human tendency to form impressions of others is ubiquitous and consequential. Consensus, or agreement among individuals, regarding their first impressions based on the facial appearance of others can lead to the treatment of other individuals in particular ways that shape their outcomes and behaviors. For an impression to be considered accurate it must not only be consensual but must also show correspondence to an external criterion, such as whether impressions of individuals’ leadership ability are related to the performance of their group or organization. Many of our first impressions may not have valid external criteria to enable an assessment of the accuracy of the impression. Yet, whether our impressions are accurate or merely consensual, they can still often predict important outcomes. A limited but growing literature has shown that our impressions can be both consensual and predictive despite important social and perceptual distinctions, such as differences in culture.     

Familiarity increases the accuracy of categorizing male sexual orientation

Although individual differences are known to influence numerous aspects of social perception, such as person memory and individuation, little is known about how such variations may affect social categorization. Extending prior research, the present study tested one potential moderator: familiarity with group members. Specifically, straight participants (n = 84) reported their real-life experiences with gay men and categorized faces as gay or straight. Results showed that participants who reported greater familiarity with gay men were significantly more sensitive, or accurate, in judging the sexual orientations of men from their faces. These results are discussed in terms of their theoretical implications for social perception and future research directions are outlined.     

Found in translation: cross-cultural consensus in the accurate categorization of male sexual orientation

Across cultures, people converge in some behaviors and diverge in others. As little is known about the accuracy of judgments across cultures outside of the domain of emotion recognition, the present study investigated the influence of culture in another area: the social categorization of men's sexual orientations. Participants from nations varying in their acceptance of homosexuality (United States, Japan, and Spain) categorized the faces of men from all three cultures significantly better than chance guessing. Moreover, categorizations of individual faces were significantly correlated among the three groups of perceivers. Americans were significantly faster and more accurate than the Japanese and Spanish perceivers. Categorization strategies (i.e., response bias) also varied such that perceivers from cultures less accepting of homosexuality were more likely to categorize targets as straight. Male sexual orientation therefore appears to be legible across cultures.     

Tough and tender: embodied categorization of gender

Emerging evidence has shown that human thought can be embodied within physical sensations and actions. Indeed, abstract concepts such as morality, time, and interpersonal warmth can be based on metaphors that are grounded in bodily experiences (e.g., physical temperature can signal interpersonal warmth). We hypothesized that social-category knowledge is similarly embodied, and we tested this hypothesis by examining a sensory metaphor related to categorical judgments of gender. We chose the dimension of "toughness" (ranging from tough to tender), which is often used to characterize differences between males and females. Across two studies, the proprioceptive experience of toughness (vs. tenderness) was manipulated as participants categorized sex-ambiguous faces as male or female. Two different manipulations of proprioceptive toughness predictably biased the categorization of faces toward "male." These findings suggest that social-category knowledge is at least partially embodied.