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71.
72.
Frankland PW Ding HK Takahashi E Suzuki A Kida S Silva AJ 《Learning & memory (Cold Spring Harbor, N.Y.)》2006,13(4):451-457
Following initial encoding, memories undergo a prolonged period of reorganization. While such reorganization may occur in many different memory systems, its purpose is not clear. Previously, we have shown that recall of recent contextual fear memories engages the dorsal hippocampus (dHPC). In contrast, recall of remote contextual fear memories engages a number of different cortical regions, including the anterior cingulate cortex (ACC). To examine whether this reorganization leads to greater memory stability, we examined reconsolidation of 1 d-old (recent) and 36 d-old (remote) contextual fear memory in mice. We infused the protein synthesis inhibitor, anisomycin (ANI), into either the dHPC or ACC immediately following retrieval of either a recent or remote contextual fear memory. In the dHPC, ANI infusions disrupted subsequent expression of recent, but not remote, contextual fear memory. Similar infusions into the ACC had no effect on either recent or remote contextual fear memories, whereas systemically applied ANI blocked subsequent remote memory expression when long re-exposure durations were used. Together, these data suggest that as memories mature they become increasingly stable. Furthermore, the dissociation between the effects of systemically and centrally administered ANI on remote memory suggests that stability is due, in part, to the distributed nature of remote contextual fear memories. 相似文献
73.
Two experiments examined adult humans’ folk physics (i.e., their naturally occurring and spontaneous understanding of the
physical world) using variations of trap-table problems used to study chimpanzees’ folk physics. When presented with these
problems, people unnecessarily avoided retrieving a reward by pulling a rake on the side of a table with a trapping hole—even
though it was highly unlikely that the hole would trap the reward. However, when the distance between the reward and the trap
was sufficiently large and the distance that the reward had to travel to be retrieved was sufficiently short, people preferred
to retrieve a reward by pulling the rake on the side of the table with the trap. These results underscore that behavior during
tool-use tasks has many possible causes, only one of which might be a subject’s folk physics. 相似文献
74.
da Silva WC Bonini JS Bevilaqua LR Izquierdo I Cammarota M 《Neurobiology of learning and memory》2006,86(1):100-106
Several evidences suggest that brain histamine is involved in memory consolidation but the actual contribution of the hippocampal histaminergic system to this process remains controversial. Here, we show that when infused into the CA1 region of the dorsal hippocampus immediately after training in an inhibitory avoidance task, but not later, histamine induced a dose-dependent promnesic effect without altering locomotor activity, exploratory behavior, anxiety state or retrieval of the avoidance response. The facilitatory effect of intra-CA1 histamine was mimicked by the histamine N-methyltransferase inhibitor SKF-91844 as well as by the H2 receptor agonist dimaprit and it was blocked completely by the H2 receptor antagonist ranitidine. Conversely, the promnesic action of histamine was unaffected by the H1 receptor antagonist pyrilamine, the H3 receptor antagonist, thioperamide, and the NMDAr polyamine-binding site antagonist ifenprodil. By themselves, ranitidine, pyrilamine, thioperamide, and ifenprodil did not affect IA memory consolidation. Our data indicate that, when given into CA1, histamine enhances memory consolidation through a mechanism that involves activation of H2 receptors; however, endogenous CA1 histamine does not seem to participate in the consolidation of IA memory at least at the post-training times analyzed. 相似文献
75.
Cherry KE Su LJ Welsh DA Galea S Jazwinski SM Silva JL Erwin MJ 《Journal of applied social psychology》2010,40(10):2463-2487
This study examined the impact of Hurricanes Katrina and Rita on cognitive and psychosocial functioning among middle-aged (45-64 years), older (65-89 years) and oldest-old adults (90 years and over) in the Louisiana Healthy Aging Study (LHAS). Analyses of pre- and post-disaster cognitive data showed storm-related decrements in working memory for the middle-aged and older adults, but not for the oldest-old adults. Regression analyses confirmed that measures of social engagement and storm-related disruption significantly predicted pre- to post-disaster differences in short-term and working memory performance for the middle-aged and older adults only. These results are consistent with a burden perspective on post-disaster psychological reactions. Implications for current views of disaster reactions are discussed. 相似文献
76.
The effects of reinforcer magnitude and response requirement on pigeons' say choices in an experimental homologue of human say-do correspondence were assessed in two experiments. The procedure was similar to a conditional discrimination procedure except the pigeons chose both a sample stimulus (the say component) and a comparison stimulus that corresponded to it (the do component). Correspondence was trained on red, green, and white key colors before the duration of food presentations following correspondence on each key color (Experiment 1) and the number of key pecks required as the say response on each key color (Experiment 2) were manipulated in an attempt to influence the initial say response. The frequency of say responses on each key color coincided with programmed changes in the duration of food presentations and the key-peck requirements assigned to each key color. Correspondence accuracy remained stable in all conditions, even those in which the say responding occurred primarily on two of the three key colors. Implications for human behavior are discussed. 相似文献
77.
Laura Jobson Nina Whittles Eleana Tsecoutanis Sanjana Raj Rui Ying Yew Shamsul Haque 《Memory (Hove, England)》2013,21(8):1054-1062
ABSTRACTCultural differences in autobiographical memory characteristics and function have often been presumed to be associated with different cultural beliefs related to the self. The current research aimed to investigate whether self-construal mediated the relationship between cultural group and the characteristics and functional use of autobiographical memory. Caucasian Australians (n?=?71) and Malay Malaysians (n?=?50) completed an online questionnaire that included the Self-Defining Memory task, the Thinking About Life Experiences Revised Questionnaire and the Self Construal Scale. As expected, the Australian group provided longer, more autonomously oriented, specific memories than the Malay group. However, contrary to our predictions, self-construal did not mediate the relationships between cultural group and memory characteristics. The Malay group reported more frequently using autobiographical memories for self-continuity than the Australian group. Finally, there was support for an indirect pathway between cultural group and use of autobiographical memories for self-continuity and social-bonding through self-construal (i.e. independent self relative to interdependent self). The findings highlight the importance of explicitly examining values assumed to be associated with autobiographical remembering, and relating these values to memory characteristics and function. 相似文献
78.
探索能够提高护生共情能力的干预模式,为改善护生的沟通技能提供参考.以杰弗逊共情量表-护生专用版(JSPE NS)为研究工具,采用系统随机抽样方法抽取86名学生作为研究对象,并随机分为干预组和对照组各43名.两组学生均参加正常的人文课程学习,干预组还接受观看视频、小组讨论等.86名学生完成了研究.干预组的共情得分高于对照组(P<0.001),干预组女生的共情得分从干预前107.42提高到119.33,差异具有统计学意义(P<0.001),干预效果对于男生并不明显,差异无统计学意义(P>0.05).男生与女生具有不同的共情特点,女生的干预效果要优于男生.培训课程的学习对提高护生的共情能力具有积极的意义. 相似文献
79.
Although the ability to stand from a seated posture is relevant for clinical practice, there are few studies investigating the process of acquisition and refinement of the motor components involved in sit-to-stand movement (STS) in children. Therefore, this longitudinal study aims to describe kinematic characteristics of the STS movement in children from 12 to 18 months, and also to investigate the relationship between changes in STS movement and childrens’ daily-life mobility. Ten healthy children were evaluated at 12,13,14,15 and 18 months of age. A motion analysis system was used to measure total duration of STS movement and angular movements of each joint, and frequencies of successful and unsupported STS were obtained. The Pediatric Evaluation of Disability Inventory was used to assess childrens’ daily-life mobility. Results showed that children tend to increase the frequency of successful trials over the months by reducing the total duration and decreasing peak ankle dorsiflexion and trunk flexion during STS. Children also started to stand up from chair with decreased trunk flexion angle among ages. At the end of the STS, we observed decreases in trunk flexion and knee flexion over age. Furthermore, kinematic characteristics that reflect improvements in STS movement are related to better performance of functional skills and decreased level of assistance provided by the caregiver in daily-life mobility of younger children. However, the strength of these associations decreases from 14 months of age onwards. 相似文献
80.