Context preexposure prevents forgetting of a contextual fear memory: implication for regional changes in brain activation patterns associated with recent and remote memory tests

Contextual fear conditioning was maintained over a 15-day retention interval suggesting no forgetting of the conditioning experience. However, a more subtle generalization test revealed that, as the retention interval increased, rats showed enhanced generalized fear to an altered context. Preexposure to the training context prior to conditioning, however, prevented this enhanced generalized fear from developing. These results support the hypothesis that the memory representation of the context degrades as the memory ages and is responsible for enhanced generalization. The implications of these results for systems consolidation versus forgetting interpretations of regional changes in neural activation patterns that occur as memories age are discussed.     

Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior

Evidence suggests that two regions of the striatum contribute differential support to instrumental response selection. The dorsomedial striatum (DMS) is thought to support expectancy-mediated actions, and the dorsolateral striatum (DLS) is thought to support habits. Currently it is unclear whether these regions store task-relevant information or just coordinate the learning and retention of these solutions by other brain regions. To address this issue, we developed a two-lever concurrent variable-interval reinforcement operant conditioning task and used it to assess the trained rat's sensitivity to contingency shifts. Consistent with the view that these two regions make different contributions to actions and habits, injecting the NMDA antagonist DL-AP5 into the DMS just prior to the shift impaired the rat's performance but enhanced performance when injected into the DLS. To determine if these regions support memory content, we first trained rats on a biased concurrent schedule (Lever 1: VI 40" and Lever 2: VI 10"). With the intent of "erasing" the memory content stored in striatum, after this training we inhibited the putative memory-maintenance protein kinase C isozyme protein kinase Mζ (PKMζ). Infusing zeta inhibitory peptide (ZIP) into the DLS enhanced the rat's ability to adapt to the contingency shift 2 d later, whereas injecting it into the DMS had the opposite effect. Infusing GluR2(3Y) into the DMS 1 h before ZIP infusions prevented ZIP from impairing the rat's sensitivity to the contingency shift. These results support the hypothesis that the DMS stores information needed to support actions and the DLS stores information needed to support habits.     

Suicidal ideation,affective lability,and religion in depressed adults

Suicidal ideation is a strong precursor to suicidal acts and like depression is complex with many risk and protective factors. The purpose of this study is to determine if affect lability, positive and negative religion/spirituality (RS) are related to suicidal ideation and if RS mediates the relationship between affect lability and suicidal ideation. RS are used synonymously to reflect a multidimensional construct. In this cross-sectional study of 183 depressed psychiatric patients, we confirm that depression and affective lability both contribute to suicidal ideation. Positive RS is associated with lower suicidal ideation. Negative RS is associated with higher suicidal ideation; however, this occurs through its association with affective lability. Affective lability and negative aspects of RS are two factors related to suicide ideation that could be addressed in the treatment of depressed patients.     

A Capacitarian Account of Culpable Ignorance

Ignorance usually excuses from responsibility, unless the person is culpable for the ignorance itself. Since a lot of wrongdoing occurs in ignorance, the question of what makes ignorance culpable is central for a theory of moral responsibility. In this article I examine a prominent answer, which I call the ‘volitionalist tracing account,’ and criticize it on the grounds that it relies on an overly restrictive conception of responsibility‐relevant control. I then propose an alternative, which I call the ‘capacitarian conception of control,’ and on the basis of it I advance an account of culpable ignorance that avoids the skeptical upshots of the volitionalist proposal. If correct, my account establishes three important truths: agents can be directly in control of their ignorance, they can be directly responsible for more than actions and omissions, and their moral obligations extend beyond the performance of intentional actions and omissions.     

Parental Role Portrayals in Twentieth Century Children’s Picture Books: More Egalitarian or Ongoing Stereotyping?

Gender role stereotyping continues to dominate within many media forms. This research examined the portrayals of mothers and fathers as companions, disciplinarians, caregivers, nurturers, and providers in 300 twentieth century children’s picture books randomly selected from the Children’s Catalog (H.W. Wilson Company, 2001). The books were published in the United States between the years of 1902 and 2000. The list of texts was stratified by time periods before sampling. The impact of time of publication upon each of the five parental role constructs was assessed using cross-tabulations. Previous analyses suggest traditional parental role portrayals are commonplace, but by employing time of publication as an independent variable, the researchers questioned whether an evolvement of roles would be noted. By examining the father and mother role performances independently over time it was expected that some progression toward egalitarianism would be noted. Overall, mothers did outperform fathers in nurturing and caregiving, and fathers outperformed mothers in companion and providing behaviors. However, when these behaviors were cross-tabulated with time of publication, no significant role evolvement was found. For example, while not statistically significant, father characters were most likely to nurture, provide care, and act as a child’s companion in books published in the 1970s, but these behaviors declined in subsequent time periods. The role evolvement of mother characters also lacked statistical significance, suggesting that the traditional male breadwinner-female homemaker model has been consistently portrayed in children’s picture books.     

Polytomous Latent Scales for the Investigation of the Ordering of Items

We propose three latent scales within the framework of nonparametric item response theory for polytomously scored items. Latent scales are models that imply an invariant item ordering, meaning that the order of the items is the same for each measurement value on the latent scale. This ordering property may be important in, for example, intelligence testing and person-fit analysis. We derive observable properties of the three latent scales that can each be used to investigate in real data whether the particular model adequately describes the data. We also propose a methodology for analyzing test data in an effort to find support for a latent scale, and we use two real-data examples to illustrate the practical use of this methodology.     

Why a family perspective for pain?

Although it is well established that families have a strong influence on individuals' beliefs and behaviors related to health and illness, relatively little attention has been devoted to the family's role in the development, maintenance, and treatment of pain or to the impact of chronic pain in one family member upon other family members. A major source of information about pain and how to respond to pain symptoms is learned within the family setting. This article reviews ways in which pain conceptualizations are developed in the family and highlights the need to more carefully study health as well as dysfunctional family reactions to chronic pain. A case example is presented that details the far reaching consequences that chronic pain can have on family life. It is concluded that more careful research, particularly in terms of the operationalization of theoretical constructs and the reliable assessment of these constructs, is needed before any definitive statements can be made about the importance and characteristics of pain-family transactions.     

Role of identity integration on the relationship between perceived racial discrimination and psychological adjustment of multiracial people

This study examined relations between perceived racial discrimination, multiracial identity integration (i.e., racial distance and racial conflict), and psychological adjustment (i.e., distress symptoms, positive affect, and negative affect) of 263 multiracial adults, using an online cross-sectional survey design. As hypothesized, higher levels of perceived racial discrimination was related to lower levels of psychological adjustment (i.e., higher distress symptoms and negative affect). Also, higher levels of multiracial identity integration with low racial conflict was related to higher levels of psychological adjustment (i.e., lower distress symptoms and negative affect), whereas higher levels of multiracial identity integration with low racial distance was related to higher levels of psychological adjustment (i.e., lower negative affect). Finally, multiracial identity integration (i.e., lower racial conflict) moderated the relationship between perceived racial discrimination and psychological adjustment (i.e., negative affect) with results suggesting multiracial identity integration related to low racial conflict buffers the negative effects of perceived racial discrimination on psychological adjustment. Findings from this study are discussed in terms of future research on the psychological well-being of multiracial individuals and implications for clinical practice with multiracial adults.     

Conjunctive representations,the hippocampus,and contextual fear conditioning

The context in which events occur can be represented as both (1) a set of independent features, the feature representation view, and (2) a set of features bound into a unitary representation, the conjunction representation view. It is assumed that extrahippocampal (e.g., neocortical) areas provide a basis for feature representations, but the hippocampal formation makes an essential contribution to the automatic storage of conjunctive representations. We develop this dual-representation view and explore its implications for hippocampal contributions to contextual fear conditioning processes. To this end, we discuss how our framework can resolve some of the conflicts in the recent literature relating the hippocampus to contextual fear conditioning. We also present new data supporting the role of a key mechanism afforded by conjunctive representations—pattern completion (the ability of a subset of a memory pattern to activate the complete memory)—in contextual fear conditioning. As is implied by this mechanism, we report that fear can be conditioned to the memory representation of a context that is not actually present at the time of shock. Moreover, this result is predicted by our computational model of cortical and hippocampal function. We suggest that pattern completion demonstrated in animals and by our model provides a mechanistic bridge to human declarative memory.