Suicidal ideation,affective lability,and religion in depressed adults

Suicidal ideation is a strong precursor to suicidal acts and like depression is complex with many risk and protective factors. The purpose of this study is to determine if affect lability, positive and negative religion/spirituality (RS) are related to suicidal ideation and if RS mediates the relationship between affect lability and suicidal ideation. RS are used synonymously to reflect a multidimensional construct. In this cross-sectional study of 183 depressed psychiatric patients, we confirm that depression and affective lability both contribute to suicidal ideation. Positive RS is associated with lower suicidal ideation. Negative RS is associated with higher suicidal ideation; however, this occurs through its association with affective lability. Affective lability and negative aspects of RS are two factors related to suicide ideation that could be addressed in the treatment of depressed patients.     

Parental Role Portrayals in Twentieth Century Children’s Picture Books: More Egalitarian or Ongoing Stereotyping?

Gender role stereotyping continues to dominate within many media forms. This research examined the portrayals of mothers and fathers as companions, disciplinarians, caregivers, nurturers, and providers in 300 twentieth century children’s picture books randomly selected from the Children’s Catalog (H.W. Wilson Company, 2001). The books were published in the United States between the years of 1902 and 2000. The list of texts was stratified by time periods before sampling. The impact of time of publication upon each of the five parental role constructs was assessed using cross-tabulations. Previous analyses suggest traditional parental role portrayals are commonplace, but by employing time of publication as an independent variable, the researchers questioned whether an evolvement of roles would be noted. By examining the father and mother role performances independently over time it was expected that some progression toward egalitarianism would be noted. Overall, mothers did outperform fathers in nurturing and caregiving, and fathers outperformed mothers in companion and providing behaviors. However, when these behaviors were cross-tabulated with time of publication, no significant role evolvement was found. For example, while not statistically significant, father characters were most likely to nurture, provide care, and act as a child’s companion in books published in the 1970s, but these behaviors declined in subsequent time periods. The role evolvement of mother characters also lacked statistical significance, suggesting that the traditional male breadwinner-female homemaker model has been consistently portrayed in children’s picture books.     

Polytomous Latent Scales for the Investigation of the Ordering of Items

We propose three latent scales within the framework of nonparametric item response theory for polytomously scored items. Latent scales are models that imply an invariant item ordering, meaning that the order of the items is the same for each measurement value on the latent scale. This ordering property may be important in, for example, intelligence testing and person-fit analysis. We derive observable properties of the three latent scales that can each be used to investigate in real data whether the particular model adequately describes the data. We also propose a methodology for analyzing test data in an effort to find support for a latent scale, and we use two real-data examples to illustrate the practical use of this methodology.     

Conjunctive representations,the hippocampus,and contextual fear conditioning

The context in which events occur can be represented as both (1) a set of independent features, the feature representation view, and (2) a set of features bound into a unitary representation, the conjunction representation view. It is assumed that extrahippocampal (e.g., neocortical) areas provide a basis for feature representations, but the hippocampal formation makes an essential contribution to the automatic storage of conjunctive representations. We develop this dual-representation view and explore its implications for hippocampal contributions to contextual fear conditioning processes. To this end, we discuss how our framework can resolve some of the conflicts in the recent literature relating the hippocampus to contextual fear conditioning. We also present new data supporting the role of a key mechanism afforded by conjunctive representations—pattern completion (the ability of a subset of a memory pattern to activate the complete memory)—in contextual fear conditioning. As is implied by this mechanism, we report that fear can be conditioned to the memory representation of a context that is not actually present at the time of shock. Moreover, this result is predicted by our computational model of cortical and hippocampal function. We suggest that pattern completion demonstrated in animals and by our model provides a mechanistic bridge to human declarative memory.     

A collaborative approach in the treatment of chronic pain

The impact of chronic pain on patients and their families can be devastating, with significant disruption and progressive deterioration of many life functions and roles. Typically, chronic pain patients have exhausted all standard medical treatment alternatives without finding relief from the pain. For chronic pain patients and their families, this leads to dependency on the health-care system which leaves patients and their families feeling helpless and hopeless in their struggle to survive their pain experiences. Assessment and treatment of chronic pain requires a comprehensive approach based on a multidimensional conceptualisation of pain that addresses cognitive, affective, behavioural, as well as sensory factors in the pain experience. A cognitive-behavioural treatment programme consisting of (a) a comprehensive multidimensional assessment, (b) a reconceptualisation aspect, (c) a skills acquisition phase, (d) a skills application, maintenance, and generalisation component, and (e) relapse prevention, is outlined. Emphasis is given to the important inter-related roles of the collaborative therapeutic relationship, reconceptualisation of the pain experience, and coping skills training, leading to self-management of life with pain as the ultimate treatment objective.     

Why a family perspective for pain?

Although it is well established that families have a strong influence on individuals' beliefs and behaviors related to health and illness, relatively little attention has been devoted to the family's role in the development, maintenance, and treatment of pain or to the impact of chronic pain in one family member upon other family members. A major source of information about pain and how to respond to pain symptoms is learned within the family setting. This article reviews ways in which pain conceptualizations are developed in the family and highlights the need to more carefully study health as well as dysfunctional family reactions to chronic pain. A case example is presented that details the far reaching consequences that chronic pain can have on family life. It is concluded that more careful research, particularly in terms of the operationalization of theoretical constructs and the reliable assessment of these constructs, is needed before any definitive statements can be made about the importance and characteristics of pain-family transactions.     

The role of the dorsal striatum and dorsal hippocampus in probabilistic and deterministic odor discrimination tasks

Three experiments explored the contribution of the cortico-striatal system and the hippocampus system to the acquisition of solutions to simultaneous instrumental odor discriminations. Inactivation of the dorsal striatum after rats had reached criterion on a three problem probabilistic set of discriminations--A (80%) vs. B (20%), C (67%) vs. D (33%), E(67%) vs. F(33%)--impaired test performance and disrupted performance when the rats were tested with novel cue combinations (C vs. F and E vs. D), where control animals chose C and F. In contrast, inactivating the dorsal hippocampus enhanced performance on this task and on a deterministic discrimination A (100%) vs. B (0%). These results are consistent with the complementary learning systems view, which assumes that the cortico-striatal and hippocampal system capture information in parallel. How this information combines to influence task performance depends on the compatibility of the content captured by each system. These results suggest that the trial-specific information captured by the hippocampal system can be incompatible with the across-trial integration of trial outcomes captured by the cortico-striatal system.     

Is there a baby in the bathwater? Maybe: some methodological issues for the de novo protein synthesis hypothesis

The de novo protein synthesis hypothesis has a long history and will no doubt continue to influence research. Yet, the primary behavioral evidence for this claim continues to come from studies in which amnesia is produced by broad scale protein synthesis inhibitors such as anisomycin. What is remarkable is the uncritical acceptance of the idea that because anisomycin is a protein synthesis inhibitor then it must have produced amnesia because it prevented translation. Several viable alternative interpretations of such experiments are discussed here and it is concluded that there is nothing to be gained by the continued use of broad-scaled antibiotics to address this hypothesis. Moreover, this approach cannot answer two critical and related questions - why must new proteins be synthesized and what are they? A focus on specific proteins such as those synthesized locally and upregulate the translation of other proteins may be a promising approach to answering these questions.