Toward an electrocortical biomarker of cognition for newborn infants

The event-related potential (ERP) effect of mismatch negativity (MMN) was the first electrophysiological probe to evaluate cognitive processing (change detection) in newborn infants. Initial studies of MMN predicted clinical utility for this measure in identification of infants at risk for developmental cognitive deficits. These predictions have not been realized. We hypothesized that in sleeping newborn infants, measures derived from wavelet assessment of power in the MMN paradigm would be more robust markers of the brain's response to stimulus change than the ERP-derived MMN. Consistent with this premise, we found increased power in response to unpredictable and infrequent tones compared to frequent tones. These increases were present at multiple locations on the scalp over a range of latencies and frequencies and occurred even in the absence of an ERP-derived MMN. There were two predominant effects. First, theta band power was elevated at middle and late latencies (200 to 600 ms), suggesting that neocortical theta rhythms that subserve working memory in adults are present at birth. Second, late latency (500 ms) increased power to the unpredictable and infrequent tones was observed in the beta and gamma bands, suggesting that oscillations involved in adult cognition are also present in the neonate. These findings support the expectation that frequency dependent measures, such as wavelet power, will improve the prospects for a clinically useful test of cortical function early in the postnatal period.     

Iraq and Afghanistan Veterans’ Experiences Living with their Parents after Separation from the Military

When military service members separate from the military, many return to their families of origin, living with their parents for a period of several weeks to years. While research with veterans and their spouses has documented the particular strain of this reintegration period on veterans and their partners, little research to date has examined veterans’ experiences living with their parents. The present study sought to fill this research gap by investigating veterans’ experiences living with their parents using qualitative, in-depth interviews with Iraq and Afghanistan veterans in California. Overall, veterans appreciated the instrumental and emotional support their parents provided when they separated. However, in some cases, living with parents also produced conflict and strain. In situations where adult veteran children had difficulty with the transition to civilian life or returned with mental health problems, parents were often the first to identify these problems and to support their children in accessing appropriate care. We analyze these findings in light of family systems theory, identifying ways in which adult veteran children continue a process of differentiation while living with their parents and maintaining emotional connectedness. We suggest ways that clinicians can better support veterans and their parents through the reintegration period and recommend that programming for military families explicitly include parents of service members in addition to conjugal families.     

BONE MARROW TRANSPLANTATION IN A PATIENT WHO EXPERIENCED TORTURE IN A PRISONER OF WAR CAMP: NARCISSISM AND SURVIVAL

Post-traumatic stress disorder has been described as a syndrome from which an individual may suffer as a result of extraordinary trauma. Torture of prisoners of war in Serbian camps during the war in Croatia is just such a stressful situation that requires mobilization of all defense mechanisms of an individual. The authors present a case study of a former prisoner of war who acquired acute myelogenous leukemia several months after release and was treated with bone marrow transplantation. On release the patient was medically examined, like all prisoners of war, and the findings did not suggest any disease. Because of the situation, the patient was in psychotherapeutic observation and treatment after his illness was diagnosed and throughout the transplantation treatment.     

Global problems,globalization, and predictability

The term globalization is questioned in its validity and applicability to structures other than verbal. Globalization is a historical term which changes its meaning with time and culture. It is not only that its content changes but the validity of a globalization concept changes with the historical perspective. Morever, solution of global problems depends heavily on the correct analysis of the problem. Without such an analysis there is no possibility to find even an approximate solution. Hence, predictability is impossible. There is no trend which is sufficiently long to make any reliable prediction for global problems other than the most simple ones.     

Suicide attempts: Patients with and without an affective disorder show impaired autobiographical memory specificity

A number of studies have shown reduced recall of specific autobiographical memories (AMs) in patients after attempted suicide, but in all of them the study samples were confounded with diagnoses of affective disorders. The present study aims to demonstrate impaired specific autobiographical memory in patients after a suicide attempt without a diagnosis of an affective disorder. Four groups were compared: (1) patients with an actual major depression and a suicide attempt; (2) patients after a suicide attempt without a lifetime history of an affective diagnosis; (3) patients currently suffering from major depression without a suicide attempt; and (4) control persons not suffering from either of the two conditions during their entire life. Individuals with major depression and a suicide attempt showed reduced specificity of AM and, most importantly, patients with a suicide attempt—despite the absence of an affective disorder—were equally impaired with recall of specific AMs as were patients with major depression. The authors propose that reduced specific AM is a common vulnerability factor that can lead either to the development of an affective disorder and/or to a suicide attempt.     

How equivalent are the action execution,imagery, and observation of intransitive movements? Revisiting the concept of somatotopy during action simulation

Jeannerod (2001) hypothesized that action execution, imagery, and observation are functionally equivalent. This led to the major prediction that these motor states are based on the same action-specific and even effector-specific motor representations. The present study examined whether hand and foot movements are represented in a somatotopic manner during action execution, imagery, and action observation.     

Scent-evoked nostalgia

Declarative and non-declarative memories are thought be supported by two distinct memory systems that are often posited not to interact. However, Wagner, Maril, and Schacter (2000a) reported that at the time priming was assessed, greater behavioural and neural priming was associated with lower levels of subsequent recognition memory, demonstrating an interaction between declarative and non-declarative memory. We examined this finding using a similar paradigm, in which participants made the same or different semantic word judgements following a short or long lag and subsequent memory test. We found a similar overall pattern of results, with greater behavioural priming associated with a decrease in recognition and recall performance. However, neither various within-participant nor various between-participant analyses revealed significant correlations between priming and subsequent memory performance. These data suggest that both lag and task have effects on priming and declarative memory performance, but that they are largely independent and occur in parallel.     

Neuropsychological profiles of children with depressive and anxiety disorders

The neuropsychological functioning of 56 children and young adolescents with diagnoses of unipolar depression (n = 17), anxiety disorder (n = 19), or comorbid anxiety/depressive disorder (n = 20) was examined. The neuropsychological profiles of the three groups were parallel, but not equal in level of performance. The three groups displayed similar patterns of performance with profiles suggesting diminished attention abilities. The groups, however, were not equal in level of performance. While subjects with an anxiety or a depressive disorder were similar in level of performance, subjects with a comorbid anxiety/depressive disorder generally performed worse than those with either an anxiety or depressive disorder alone. There was no significant evidence of asymmetrical cerebral dysfunction in any of the diagnostic groups. Results are discussed in relation to adult models of psychopathology with an emphasis on the importance of considering developmental factors when formulating models of childhood psychopathology.     

Modeling the Neurological Control of Human Movements

Although computer models have been extensively used in recent years to understand the way physical systems operate and interact, the enormous power of mathematical modeling and computer simulations has been difficult to implement for the benefit of neuroscientists studying the human motor control system. Nevertheless, homeomorphic models are now being used to explain and predict the neural and biomechanical aspects of different human movements. This paper argues for the importance of regarding model simulations as a supplementary approach to traditional methods of experimental investigation by drawing examples from both the experimental and the modeling literature. The discussion focuses on studies of the triphasic control signal for fast, goal-directed movements and on aspects of sampled data control for slow, tracking movements. The aim of this viewpoint article is to promote a more widespread use of modeling and simulation in the field of motor control.     

The Development of the Concept of Concrete Subjectivity from Kant to Neo-Kantianism

One long-running conundrum in Husserlian phenomenology revolves around the question of the identity of what Husserl calls the transcendental ego, a mysterious figure that he identifies as the subject of a genuinely transcendental phenomenology. In dialogue with both Husserl and his assistant and collaborator Eugen Fink (as well as recent commentary), I attempt in this article to give a solid account of the identity of this transcendental ego, and in particular to explain the connection between this figure and the empirical ego of the individual phenomenologist. I make particular reference to Fink's depiction of a "personal union" between these two egos in his Sixth Cartesian Meditation and to certain unclear hints in Husserl's 1923/1924 lectures on First Philosophy. Ultimately, I develop my own account of such a union, which explains the transcendental ego as a certain mode in which the phenomenologist might investigate his own experiences. On this basis, I argue, the status of phenomenology as a transcendental discipline can be understood without subjecting that discipline to certain criticisms that have been levelled against it.