Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory

Metabotropic glutamate receptors (mGluRs) are known to play a role in synaptic plasticity and learning. We have previously shown that mGluR7 deletion in mice produces a selective working memory (WM) impairment, while other types of memory such as reference memory remain unaffected. Since WM has been associated with Theta activity (6-12 Hz) in EEGs, and since EEG abnormalities have been observed in these mice before, we studied the effect of mGluR7 gene ablation on EEG activity in the hippocampus, in particular in the Theta range, during performance of a WM task. In an eight-arm maze with four arms baited, mGluR7 knock-out (KO) and wild-type mice committed the same number of reference memory errors, whereas KOs committed more WM errors. While performing the task, KO mice showed substantially higher Theta amplitudes, and the ratio of Theta to overall EEG power was much increased. No change was seen in the Delta (0-5 Hz), or Gamma (30-40 Hz) EEG bands compared with controls. When recording EEGs during periods of rest in the home cages, no difference was seen between groups. These findings suggest that mGluR7 is important for modulation and control of Theta activity. Since only WM was affected, and only the Theta range of EEG activity was altered, these results show a correlation between Theta rhythm and WM performance, and therefore support the concept that Theta activity in the hippocampus is involved in WM storage.     

Respiration and postural sway: detection of phase synchronizations and interactions

The aim of the central nervous system in upright stance is to control an intrinsically unstable plant. Internal disturbances, such as haemodynamics and respiration, constitute an endogenous threat to equilibrium. The way CNS reacts to those perturbations was studied in this work, through the analysis of summary scores taken from posturographic and pneumographic data. Signals were recorded simultaneously during trials administered on a sample population of healthy young adults, while sitting and standing and at paced and spontaneous uncontrolled breathing. The extraction of posturographic and pneumographic parameters was accompanied by the utilization of techniques for the detection of phase synchronization in bivariate data, and the extraction of an interaction index, the mutual information MI. The effects of the biomechanical condition and respiratory amplitude on MI and summary measures were tested with a two-way ANOVA. Summary scores clearly depend on posture condition. Synchronization between breath and postural sway is always present, depends on both biomechanical condition and respiratory threat, and cannot be reduced to a simple linear relation.     

Gender Differences in Problem Drinking and Depression: Different “Vulnerabilities?”

This study examines the relationship between stressors and resources and the functioning of a sample of 515 men and women who had a drinking problem. At a one-year follow-up, both women and men had improved on three functioning measures: alcohol consumption, days intoxicated, and depression. There were no gender differences at Time 2 on alcohol consumption, but men had more days intoxicated and women had more symptoms of depression. The impact of stressors and resources varied by life domain, functioning criterion, and gender. Although the predictors varied, the amount of variance in depression accounted for was the same for women and men. The most striking gender difference was the stronger impact of friendships for women on all aspects of functioning. This study provides support for reconsideration of the stress vulnerability of women and men.     

Life Circumstances and Personal Resources as Predictors of the Ten-Year Course of Depression

A 10-year naturalistic study of 313 patients who entered treatment for unipolar depression and a community comparison group of 284 nondepressed adults was conducted. We compared life stressors, social resources, personal resources, and coping among patients who were remitted (N = 76), partially remitted (N = 146), or nonremitted (N = 91). Compared with the controls and the remitted patients, the partially remitted and nonremitted patients consistently experienced more life stressors and fewer social resources, were less easygoing, and relied more on avoidance coping. A less easygoing disposition, fewer close relationships, and more reliance on avoidance coping were associated with higher odds of experiencing a course of partial remission or nonremission. In addition, more depressive symptoms and medical conditions predicted nonremission.     

Context and coping: Toward a unifying conceptual framework

After offering a conceptual framework to unify the domains of context and coping, some conclusions are drawn about the underlying patterns of social climate and the characteristics of growth-promoting environments. New directions of research on the dynamics of the environmental system are described. The conceptual framework is used to exemplify ways to explore the stress and coping process in regard to such issues as stress and resource predictors of adaptation, stress prevention and resistance, and cross-situational influences. The foregoing material then highlights implications of a social ecological perspective for conducting conceptually informed evaluation research and changing and improving community settings. Finally, such conceptual problems as person-environment matching and the need to formulate unified perspectives of stressors and resources are discussed to identify promising ways to spark the maturation of community psychology.     

The conceptual structure of aphasic and schizophrenic patients in a nonverbal sorting task

Hierarchical and overlapping cluster methods were applied to the sortings of aphasic, nonaphasic brain-damaged, schizophrenic, and normal subjects presented with 30 pictures of animals. The hierarchical structure solutions were most diffuse for the groups of the schizophrenics and the fluent aphasics. The structure for the nonfluent aphasics showed more clarity, but was also deviant from the structures of the normals and the brain-damaged without aphasia. Fluent aphasics but not nonfluent aphasics tended to sort pictures which they could not name into smaller groups. For the nonfluent aphasics, there was a significant correlation between the commonality of the sortings and the severity of aphasic disturbances as measured by the Token Test. The relationship between conceptual disorganization and language impairment seems to be functionally different for fluent and nonfluent aphasics.This research was supported by a research grant from the Deutsche Forschungsgemeinschaft.     

Adolescent Gender and Age Differences in Responsiveness to Functional Family Therapy

The current study contributes to a sparse literature on moderators of Functional Family Therapy (FFT) by examining whether responsiveness to FFT, measured by a broad range of outcomes, varies by adolescent gender, age, and their interaction. This study was informed by 687 families (n, adolescents = 581; n, caregivers = 933) and utilized a pre–post comparison design. Fixed-effects regressions with gender, age, and their interaction included as explanatory variables were conducted to calculate the average change in youth mental health, callous–unemotional traits, academic outcomes, substance use, and family functioning. Moderation analyses revealed that according to parent report, girls had significantly greater improvements in peer problems and family functioning, and boys benefited more in increased liking of school. There were differential effects by age, such that older youth had less beneficial mental health outcomes and a smaller decrease in frequency of hash use. The gender by age interaction was significant for adolescents’ report of mental health and family functioning outcomes, which suggests that girls benefit from FFT less than boys during early adolescence, but benefit more than boys in late adolescence. This finding adds to literature which has evidenced that family functioning is particularly important for girls by suggesting that FFT is important for improving older girls’ mental health and family functioning in particular. The study’s results expand the examination of outcomes of FFT to include academic outcomes, and provide insight into key factors that should be considered in addressing adolescent behavioral problems and family functioning.     

Sex differences in self-reported coronary-prone factors

The FABA self-report questionnaire on coronary-prone behaviour was applied to 628 GDR subjects (343 males, 285 females), who included students, blue- and white-collar workers, and hypertensive patients, all split into three age groups (18–30, 31–50, and 51–65 years). Four scales had been previously established by factor analysis: Work Obsession (WO), Dominance/Competition (DC), Reactive Uncontrol (RU), and Need for Planning (PN). Two-tailed MANOVA and ANOVA were applied to analyse the effects of sex, age, and type of respondent (i.e. student, worker, or hypertensive) on scale means, using the defined sub-groups. No significant sex differences on WO and PN were found. With regard to DC, males of all sub-groups consistently rated themselves as more dominant and competitive than females. These differences were highly significant. RU was higher only in female students and female hypertensives. There was a significant age effect on DC and PN: the older the workers and hypertensives of both sexes, the more dominant and obsessed with planning they were. No influence of the type of respondent was apparent. Results are discussed in the light of cross-cultural research on gender differences and the particular socio-economic situation of the former GDR. © 1998 John Wiley & Sons, Ltd.