An investigation of the diagnostic processing of contradictory information

In three parallel experiments, subjects rated their impressions of hypothetical 20-year-old males described by means of single or combined personality trait adjectives on 36 bipolar (Semantic Differential) scales. These ratings were a) intercorrelated across the scales (Q-technique) and factor analyzed separately for each subject, and b) submitted to an analysis of variance separately for each scale. It was shown that 1) when contradictory adjectives were combined the major portion of the variance of judgments fell on dimensions independent of that which characterized the contradiction; 2) there were substantial inter-individual consistencies in the direction of the deviation from that dimension; and 3) the utility of a linear model for the prediction of judgments of combined adjectives increases with increases in the extent to which the subject experiences the combination as consistent. However, the utility of the linear model decreases considerably and consistently if the combined adjectives are experienced as non-consistent.     

Children of parents with unipolar depression: A controlled 1-year follow-up

An earlier cross-sectional study indicated that children's health and adjustment is at risk when their parents are depressed. Here, we report the associated longitudinal changes in children and families when parental depression either remits or continues. Comparisons are made among three groups established at a 1-year follow-up: previously depressed parents whose symptoms have remitted (N = 34 remitted parents), previously depressed parents who continue to be depressed (N = 23 nonremitted parents), and sociodemographically matched control families (N = 95). Although remitted parents and their family social environments improved, their children were still functioning more poorly than children of controls. Both the children and the families of nonremitted parents continued to function more poorly than controls. A social-environmental framework indicates that parents' functioning as well as family stressors and resources are concurrently and predictively linked to children's health.     

Effects of sex-role deviant lifestyles in otherwise normal persons on the perception of maladjustment

Subjects rated 12 stimulus persons (SPs) on maladjustment in several areas, and on the likelihood of requiring psychiatric help, in a person perception task. Half of the SPs were male and half female. Half of each were sex-role congruent and half sex-role deviant in terms of occupation, life styles, or interests, though normal in all other respects. Bias scores were constructed for subjects reflecting the extent to which each was influenced by sex-role deviance. Measures of gender stereotyping and sex-role ideology were also obtained. Results showed that sex-role deviant SPs were rated as significantly more maladjusted than congruent SPs and more likely to require psychiatric help. Sex-role deviance had a much greater effect on male than female SPs. Gender stereotyping and sex-role ideology showed only a moderate relationship, which suggests that these concepts should be distinguished. Measures of evaluative bias showed low to moderate relationships with sex-role ideology and very low correlations with gender stereotyping.This research is based on parts of a doctoral dissertation by the first author. It was supported by an Ontario Mental Health Foundation Research Studentship Award to the first author and by Canada Council Grant #S74-0707 to the second author.     

Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study

Hoarding behavior occurs frequently in obsessive-compulsive disorder (OCD). Results from previous studies suggest that individuals with OCD who have hoarding symptoms are clinically different than non-hoarders and may represent a distinct clinical group. In the present study, we compared 235 hoarding to 389 non-hoarding participants, all of whom had OCD, collected in the course of the OCD Collaborative Genetics Study. We found that, compared to non-hoarding individuals, hoarders were more likely to have symmetry obsessions and repeating, counting, and ordering compulsions; poorer insight; more severe illness; difficulty initiating or completing tasks; and indecision. Hoarders had a greater prevalence of social phobia and generalized anxiety disorder. Hoarders also had a greater prevalence of obsessive-compulsive and dependent personality disorders. Five personality traits were independently associated with hoarding: miserliness, preoccupation with details, difficulty making decisions, odd behavior or appearance, and magical thinking. Hoarding and indecision were more prevalent in the relatives of hoarding than of non-hoarding probands. Hoarding in relatives was associated with indecision in probands, independently of proband hoarding status. The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families.     

Sensitization and aversive conditioning: Effects on the startle reflex and electrodermal responding

Animal data suggest that shock sensitization as well as aversive learning potentiates the acoustic startle reflex. The present experiment tested, whether this shock sensitization also occurs in human subjects and whether it precedes aversive conditioning. Sixty subjects viewed—prior to conditioning—a series of slides of different emotional contents including the to be conditioned stimuli (CSs). Afterwards, the experimenter attached the shock electrodes and initiated shock exposure. Then, subjects were randomly assigned to view a series of two slides, each for eight acquisition trials in which one slide was followed by a shock. Subsequently, extinction trials (12 for each slide) were administered. During preconditioning, acquisition, and extinction, startle probes occurred unpredictably during and between slide viewing. Preconditioning data replicated previous results by Lang and his associates, showing that the startle response magnitude is directly related to the affective valence induced by the slides. Shock exposure strongly facilitated the startle reflex magnitude. This shock sensitization was absent for the skin conductance response. Course of learning also varied for both response systems. The data suggest that startle reflex potentiation indexes the acquisition of an avoidance disposition, which is preceded by a general sensitization of the protective reflexes. Skin conductance learning follows arousal changes and is modulated by cognitive processes.     

BONE MARROW TRANSPLANTATION IN A PATIENT WHO EXPERIENCED TORTURE IN A PRISONER OF WAR CAMP: NARCISSISM AND SURVIVAL

Post-traumatic stress disorder has been described as a syndrome from which an individual may suffer as a result of extraordinary trauma. Torture of prisoners of war in Serbian camps during the war in Croatia is just such a stressful situation that requires mobilization of all defense mechanisms of an individual. The authors present a case study of a former prisoner of war who acquired acute myelogenous leukemia several months after release and was treated with bone marrow transplantation. On release the patient was medically examined, like all prisoners of war, and the findings did not suggest any disease. Because of the situation, the patient was in psychotherapeutic observation and treatment after his illness was diagnosed and throughout the transplantation treatment.     

NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis

In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in which the NT-3 gene is deleted in the brain, we investigated the role of NT-3 in adult neurogenesis, hippocampal plasticity, and memory. Bromodeoxyuridine (BrdU)-labeling experiments demonstrated that differentiation, rather than proliferation, of the neuronal precursor cells (NPCs) was significantly impaired in DG lacking NT-3. Triple labeling for BrdU, the neuronal marker NeuN, and the glial marker GFAP indicated that NT-3 affects the number of newly differentiated neurons, but not glia, in DG. Field recordings revealed a selective impairment in long-term potentiation (LTP) in the lateral, but not medial perforant path-granule neuron synapses. In parallel, the NT-3 mutant mice exhibited deficits in spatial memory tasks. In addition to identifying a novel role for NT-3 in adult NPC differentiation in vivo, our study provides a potential link between neurogenesis, dentate LTP, and spatial memory.     

Memory self-efficacy predicts memory performance: results from a 6-year follow-up study

The purpose of this study was to examine the relationship between memory self-efficacy (MSE) and a 6-year follow-up assessment of memory functioning in a sample of Dutch older adults. MSE was assessed by a Dutch abridged version of the Metamemory in Adulthood questionnaire (MIA; R. A. Dixon, D. F. Hultsch, & C. Hertzog, 1988; C. Hertzog, D. F. Hultsch, & R. A. Dixon, 1989; R. W. H. M. Ponds & J. Jolles, 1996). The total MSE score predicted memory performance at 6 years, as measured by the Visual Verbal Learning Task (VVLT; N. Brand & J. Jolles, 1985). A separate analysis of the different MSE subscales indicated that the MIA Change score was the most salient domain-specific MSE predictor of subsequent memory performance after 6 years. An extreme groups analysis of the MIA Change score revealed a pattern of performance for those who perceived that their memory was worsening, performing less well on the 3 trials of the VVLT when these were readministered at the 6-year follow-up.