Polyaminergic agents modulate contextual fear extinction in rats

Polyamines, such as spermidine and spermine, have been reported to improve memory retention through the activation of N-methyl-d-aspartate receptors (NMDAr). However whether polyamine agonists and antagonists alter extinction remains unclear. In the current study, we investigated whether spermidine and polyamine antagonists that selectively block the NR2B subunit at the NMDAr alter the extinction of contextual conditioned fear in male Wistar rats. The bilateral intra-hippocampal administration of exogenous spermidine (2 nmol/site) immediately after, but not 6 h after extinction training, facilitated the extinction of fear conditioning. The injection of the NMDAr antagonists arcaine (0.2 nmol/site), ifenprodil (20 nmol/site) and traxoprodil (0.2 nmol/site), disrupted fear extinction and, at doses that had no effect per se, reversed the facilitatory effect of spermidine on fear extinction. These results suggest that exogenous and endogenous polyamines facilitate the extinction of contextual conditioned fear through activation of NR2B subunit-containing NMDAr in the hippocampus. Since extinction-based exposure therapy is widely used as treatment for a number of anxiety-related disorders, including phobias and post-traumatic stress, the currently reported facilitation of extinction by polyaminergic agents suggest these compounds as putative candidates for drug development.     

Normatively Enriched Moral Meta‐Semantics

In order to defend the Cornell variety of naturalistic moral realism from Horgan and Timmons’ Moral Twin Earth objection, several philosophers have proposed what I call Normatively Enriched Moral Meta‐Semantics (NEMMS). According to NEMMS, the natural properties that serve as the contents of moral predicates are fixed (at least in part) by non‐moral normative facts. In this paper, I elucidate two versions of NEMMS: one proposed by David Brink, and the other proposed by Mark van Roojen. I show what these meta‐semantics have in common, and how each one promises the Cornell realist a response to the Moral Twin Earth objection. I then argue that Cornell realists ought to be wary of adopting NEMMS. A naturalist realist who adopts this meta‐semantics confronts a trilemma. The proponent of NEMMS owes a meta‐ethical account of the relevant content‐fixing normative facts. Such facts are either reducible to recognizably natural facts or they are not. If they are not reducible, then NEMMS entails the denial of ethical naturalism (and so, the denial of Cornell realism). If such facts are taken to be reducible to facts about agents’ actual or hypothetical attitudes, then (among other problems) the account renders moral facts stance‐dependent. Consequently, moral realism is false. Alternatively, one might propose that the content‐fixing normative facts are reducible to attitude‐independent natural facts. However, such a proposal is refuted by its own Twin Earth objection.     

Boundaries of Citizenship Behavior: Curvilinearity and Context in the Citizenship and Task Performance Relationship

Resource allocation, attentional capacity, and role theories all suggest that the well‐documented linear relationship between citizenship behavior and task performance may be more complex than previously believed. In a study of 352 incumbents, we develop hypotheses that propose a curvilinear effect of employee citizenship on task performance. We further argue that this nonmonotonic relationship is different across the targets of citizenship performance and is moderated by several factors from the task context. Results support the curvilinear assertion, indicating that the relationship with task performance inflects when citizenship is more frequently performed. These diminishing returns are amplified when the target of citizenship is the organization compared to the individual. Findings further reveal that the task context elements of accountability and autonomy moderate the curvilinear relationship, whereas ambiguity does not. Implications for a reappraisal of the citizenship–task performance relationship are discussed.     

Total Pragmatic Encroachment and Epistemic Permissiveness

This article explores the relationship between pragmatic encroachment and epistemic permissiveness. If the suggestion that all epistemic notions are interest‐relative is viable (as Jason Stanley has recently claimed), then it seems that a certain species of epistemic permissivism must be viable as well. For, if all epistemic notions are interest relative then, sometimes, parties in paradigmatic cases of shared evidence can be maximally rational in forming competing basic doxastic attitudes towards the same proposition. However, I argue that this total pragmatic encroachment is not tenable, and, thus, epistemic permissivism cannot be vindicated in this way.     

Trajectories of Social Withdrawal from Middle Childhood to Early Adolescence

Heterogeneity and individual differences in the developmental course of social withdrawal were examined longitudinally in a community sample (N = 392). General Growth Mixture Modeling (GGMM) was used to identify distinct pathways of social withdrawal, differentiate valid subgroup trajectories, and examine factors that predicted change in trajectories within subgroups. Assessments of individual (social withdrawal), interactive (prosocial behavior), relationship (friendship involvement, stability and quality, best friend’s withdrawal and exclusion/victimization) and group- (exclusion/victimization) level characteristics were used to define growth trajectories from the final year of elementary school, across the transition to middle school, and then to the final year of middle school (fifth-to-eighth grades). Three distinct trajectory classes were identified: low stable, increasing, and decreasing. Peer exclusion, prosocial behavior, and mutual friendship involvement differentiated class membership. Friendlessness, friendship instability, and exclusion were significant predictors of social withdrawal for the increasing class, whereas lower levels of peer exclusion predicted a decrease in social withdrawal for the decreasing class.     

American Indian Youth: Who Southwestern Urban and Reservation Youth Turn to for Help with Mental Health or Addictions

We illustrate the addictions and mental health service use of American Indian adolescents. Interviews concerning mental health need and service configurations with 401 Southwestern American Indian (AI) youth used questions from the Diagnostic Interview Schedule (DIS) and the Service Assessment for Children and Adolescents (SACA). Seventy-nine percent had mental health or addiction problems, with half meeting criteria for at least one diagnosis. One in 4 youth met criteria for drug dependence'abuse or conduct disorder, 1 in 5 for depression, and 1 in 8 for alcohol dependence'abuse. Most youth were helped by a combination of providers. Youth meeting more diagnostic criteria were increasingly likely to use service configurations with adults, nonspecialist professionals, and specialists, respectively. Regardless of disorder, youth were least likely to use configurations with traditional healers or specialists and there was little difference in rates of use between the two. The lack of services from specialist providers was potentially offset by use of an extensive range of informal adults, nonspecialist professionals, and peers. Since informal helpers, peers, and nonspecialist providers, but not specialists, are providing the bulk of services they must be given support and skills so they can function effectively.     

Socially creative appraisals of rejection bolster ethnic migrants' subjective well‐being

We examined a proposition based on social identity theory that socially creative appraisals of rejection can boost the well‐being of strongly identifying ethnic migrants. We piloted this proposition amongst women (N = 80) and found that strong (but not weak) group identifiers who considered the positive views that society holds about their social identity reported higher subjective wellbeing (self‐esteem) relative to those who dwelt on rejection. In a subsequent field experiment (N = 179) conducted amongst ethnic migrants in London, we added a further social creativity treatment in which participants were encouraged to consider how they would view immigrants if they were native British (accommodation). Results revealed that the two social creativity mindsets (accommodation and positive) combined: (a) reduced perceptions of social rejection and increased optimism over the openness and fairness of society relative to a rejection mindset, (b) enhanced the self‐esteem of strongly (but not weakly) identified ethnic migrants, and (c) enhanced ethnic migrant's wellbeing by minimizing the recall of social rejection and by strengthening optimism over the host society's openness and fairness. Implications for social change are discussed.     

Social contexts influence ethical considerations of research

This article argues that we could improve the design of research protocols by developing an awareness of and a responsiveness to the social contexts of all the actors in the research enterprise, including subjects, investigators, sponsors, and members of the community in which the research will be conducted. "Social context" refers to the settings in which the actors are situated, including, but not limited to, their social, economic, political, cultural, and technological features. The utility of thinking about social contexts is introduced and exemplified by the presentation of a hypothetical case in which one central issue is limitation of the probability of injury to subjects by selection of individuals who are not expected to live long enough for the known risks of the study to become manifest as harms. Benefits of such considerations may include enhanced subject satisfaction and cooperation, community acceptance, and improved data quality, among other desirable consequences.