Lateralized Changes in Regional Cerebral Blood Flow during Performance of Verbal and Facial Recognition Tasks: Correlations with Performance and “Effort”

Functional neuroimaging has been used to investigate neural substrates of mnemonic processes, and cerebral blood flow (CBF) measures have been sensitive to activation with memory tasks. Studies of memory with two-dimensional¹³³Xenon clearance techniques found that word and face recognition tasks produced contralateral CBF changes in mid-temporal cortical regions. This study replicated the activation paradigm, expanding to the three-dimensional resolution of positron emission tomography (PET). Word and face recognition, and a control baseline task were administered to 19 healthy right-handed volunteers (11 men, 8 women) during successive 10 min PET¹⁵O-water measures of CBF. Quantitative CBF rates were calculated with the arterial input function and the equilibrium model. Redistributions of blood flow were compared across tasks using both absolute and relative (region/whole brain) CBF.Replicating the¹³³Xenon clearance findings, CBF was “appropriately” lateralized during task performance (left–right for words > left–right for faces) in the mid-temporal region. Contrary to predictions, the recognition tasks did not activate expected mesolimbic or prefrontal areas. The task-induced CBF changes also correlated with performance. Bilateral CBF in mid-temporal and parahippocampal gyrus regions of interest correlated with the ability to correctly identify word targets (sensitivity). Left-lateralized CBF in the amygdala and hippocampus correlated with better word sensitivity as well as specificity (ability to correctly reject foils). Complementally, right-lateralized CBF in the parahippocampal gyrus correlated with better face specificity performance. In addition, left-lateralized CBF in the amygdala and right-lateralized CBF in the parahippocampal gyrus and hippocampus correlated with “mental effort” indices (task performance relative to basal ability) for word and face memory tasks, respectively. Thus, whereas this recognition task showed the expected lateralized increase in the mid-temporal region and not in frontal and limbic areas, lateralized activation in some of these areas was associated with better performance. Exploratory analyses on other regions showed lateralized changes in one additional temporal region, the occipital-temporal, and several limbic regions.     

Multiple information sources in interceptive timing

This study was designed to explore the limitations of tau (τ) as an explanatory construct for the timing of interceptive action. This was achieved by examining the effects of environmental structure and binocular vision on the timing of the grasp in a simple one-handed catch. In two experiments, subjects were required to catch luminous balls of different diameters (4, 6, 8 and 10 cm) in a completely darkened room. In the first experiment the influence of the presence vs. absence of an environmental background structure (both under monocular viewing) was tested, and in the second experiment the influence of monocular vs. binocular vision was examined. It was found that irrespective of the presence of environmental structure, an effect of ball size occurred in the monocular viewing conditions. That is, in monocular viewing conditions the grasp was initiated and completed earlier for the larger balls as compared to the smaller ones, while in the binocular viewing condition subjects behaved in accordance with a constant time to contact strategy: no effects of ball size were found. It is concluded that under binocular viewing a binocular information source is used, while in the monocular viewing condition a lower order information source like image size or image velocity is probably involved.     

The Development of a Clinical Rating Scale the McMaster Model of Family Functioning

This article describes the development and validation of the McMaster Clinical Rating Scale (MCRS). The MCRS is a 7-item scale designed to be completed by a trained rater after completion of an in-depth interview of the family. We present data from four new studies and review previously published articles concerning the reliability, validity, and clinical utility of the MCRS. Adequate interrater reliability and rater stability were obtained. The MCRS was found to correlate significantly with the self-report Family Assessment Device and to discriminate between families in different phases of a depressive disorder.     

ON ULTIMATE EPISTEMIC FOUNDATIONS1

This paper is a contribution to the debate on epistemic foundationalism. Section I expounds and criticises Hans Albert's critical rationalist antifoundationalism position. Section I1 discusses Karl-Otto Apel's ‘transcendental pragmatic’ argument for ultimate epistemic foundations. Section III suggests how the latter argument can be restated so as to avoid ambiguity and yield a plausible case for epistemic foundationalism.     

Measurement and the interpretation of quantum mechanics and relativity theory

The axiomatic approaches of quantum mechanics and relativity theory are compared with approaches in which the theories are thought to describe readings of certain measurement operations. The usual axioms are shown to correspond with classes of ideal measurements. The necessity is discussed of generalizing the formalisms of both quantum mechanics and relativity theory so as to encompass more realistic nonideal measurements. It is argued that this generalization favours an empiricist interpretation of the mathematical formalisms over a realist one.     

Extraction of relief from visual motion

We quantified the ability of human subjects to discriminate the relative distance of two points from a slanted plane when viewing the projected velocities of this scene (orthographic projection). The relative distance from a plane (called relief) is a 3-D property that is invariant under linear (affine) transformations. As such, relief canin principle be extracted from the instantaneous projected velocity field; a metric representation, which requires the extraction of visual acceleration, is not required. The stimulus consisted of a slanted planeP (specified by three points) and two pointsQ ₁ andQ ₂ that are non-coplanar withP. This configuration of points oscillated rigidly around the vertical axis. We have measured thesystematic error andaccuracy with which human subjects estimate the relative distance of pointsQ ₁ andQ ₂ from planeP as a function of the slant of_P. The systematic error varies with slant: it is low for small slant values, reaches a maximum for medium slant values, and drops again for high slant values. The accuracy covaries with the systematic error and is thus high for small and large slant values and low for medium slant values. These results are successfully modeled by a simple relief-from-motion computation based on local estimates of projected velocities. The data are well predicted by assuming (1) a measurement error in velocity estimation that varies proportionally to velocity (Weber’s law) and (2) an eccentricity-dependent underestimation of velocity.     

The dynamics of Prägnanz

Summary There is quite wide-spread agreement about the relevance of pattern Pragnanz (Koffka, 1935) with respect to the human interpretation of visual patterns. There is less agreement about whether pattern Pragnanz is based solely on pattern information (static) or also on the history of the perceiver (dynamic). In Van Leeuwen and Van den Hof (1991), experimental data concerning serial patterns are presented within the framework of the dynamic-network approach initiated by Buffart (1986, 1987). These experimental data are claimed to give evidence against the static-coding approach initiated by Leeuwenberg (1969, 1971). In the present paper, however, I show first that Buffart's theoretical basis is incorrect, and that in fact Leeuwenberg's static-coding approach is the basis for the dynamic-network approach. Second, I show that those experimental data rather give evidence in favor of the static-coding approach, by using those same data for a test of the most recent static-coding model (Van der Helm & Leeuwenberg, 1991; Van der Helm, Van Lier, & Leeuwenberg, 1992). Finally, I propose a reconciliation between the two approaches, in the sense that the dynamic-network model could be shaped in such a way that it yields a simulation, and maybe even an enrichment, of the static-coding model.     

Intuitive Perceptions of Decision-making Strategy: Naive Assessors' Concepts of Integrative Complexity

Although there are measurable differences in integrative complexity among solutions that individuals generate in dealing with problems, it is uncertain to what extent people comprehend, recognize, and have preferences among different levels of complexity. Integrative complexity is a function of differentiation (the perception of several attributes within, or perspectives about, a topic) and integration (combining the differentiated characteristics in an interactive or synthesizing solution). The current paper reports two experiments dealing with how university students perceive, interpret, and choose among solutions differing in complexity. Experiment 1 showed that subjects accurately rated the complexity of described solutions differing along the continuum, but that their assessment of their own responses differed from the results of expert scoring. Their self-estimated complexity was highly correlated with their preferences, and preferred complexity was reliably higher than either expert- or self-assessed complexity of subject-generated solutions. Subjects were able to hypothesize quite accurately about environmental and endogenous factors likely to affect complexity. Experiment 2 found that in response to problem scenarios, solutions selected as being potentially most effective were consistently more complex than solutions that participants considered themselves most likely to use. The idea of complexity seems to be intuitively recognizable and understandable by untrained subjects: They can and do distinguish among problem solutions (self-generated or presented) that vary on that dimension, and are able to assess accurately the effects of relevant variables. Such subjects also share the bias shown by experts in favour of the superiority of more complex approaches.