尼可地尔与前列地尔预处理对大鼠心肌缺血再灌注的影响

研究尼可地尔、前列地尔及两药物联合应用预处理对心肌缺血再灌注中的影响,探究其作用机制.采用Tunel法检测心肌组织的凋亡情况,免疫组化法检测Bax、Bcl-2和caspase-3的蛋白表达情况.结果显示尼可地尔和前列地尔半剂量联合组细胞凋亡数、Bax和caspase-3的表达量均明显低于其他给药组(P＜0.05),Bcl-2的表达量明显高于其他给药组(P＜0.05);尼可地尔和前列地尔单给药组细胞凋亡、Bax、caspase-3表达均有降低,Bcl-2表达升高,但效果不及联合用药半剂量组.以此得出结论尼可地尔和前列地尔的联合用药效果较好,可加强对心肌的保护作用.     

Bodily feelings and felt inclinations

Phenomenology and the Cognitive Sciences - The paper defends a version of the perceptual account of bodily feelings, according to which having a feeling is feeling something about one’s body....     

Assessing Parenting Behaviors in Euro–Canadian and East Asian Immigrant Mothers: Limitations to Observations of Responsiveness

The use of parenting measures that are developed for use with Western families without testing their validity among families from non-Western cultural backgrounds may not be appropriate. Similar parenting behaviors may affect child outcomes in different ways across different cultures. This study examined the cross-cultural validity of an observational Maternal Responsiveness coding system and of self-reports of lax/inconsistent parenting in Euro–Canadian (n = 23) and East Asian immigrant mothers (n = 23) of 4- to 7-year-old sons. In Euro–Canadian mothers, observed parenting responsiveness was associated with less lax/inconsistent parenting and fewer child behavior problems. In East Asian immigrant mothers, however, observations of greater responsiveness were not related to reports of lax/inconsistent parenting, and were associated with greater child behavior problems. Implications for the use of these parenting measures across culture groups are discussed.     

Mnemonic benefits of retrieval practice at short retention intervals

The testing effect refers to the retention benefit conferred by prior retrieval of information from memory. Although the testing effect is a robust phenomenon, a common assumption is that reliable memory benefits only emerge after long retention intervals of days or weeks. The present study focused on potential test-induced retention benefits for brief retention intervals on the order of minutes and tens of seconds. Participants in four experiments studied lists of words. Some of the items were subjected to an initial cued recall test, and others were re-presented for additional study. Free recall tests were administered in each experiment following retention intervals ranging from 30 s to 8 min. When initial retrieval practice was successful (Experiments 1 through 3), or feedback compensated for unsuccessful retrieval (Experiment 4), significant testing effects emerged at all retention intervals. Results are discussed in the context of a bifurcated item-distribution model and highlight the importance of initial test performance and the type of analysis employed when examining testing effect data.     

Using the Theory of Gender and Power to Examine Experiences of Partner Violence,Sexual Negotiation,and Risk of HIV/AIDS Among Economically Disadvantaged Women in Southern India

This article uses the Theory of Gender and Power to examine women's vulnerability to HIV/AIDS in order to: understand the vulnerability of female sex workers/poor women due to poverty and lack of educational resources; explore women's vulnerability in the context of client/partner violence, alcohol use, male partner's high-risk behaviors, and women's lack of control in their intimate relationships; and explore the role of traditional heterosexual gender norms in the outcomes of sexual negotiation. Ethnographic data were collected from 32 women and 38 men in India as part of an ongoing National Institute of Mental Health study. Results highlighted women's vulnerability to HIV/AIDS stemming from partner violence, alcohol use, poverty, dangers of sex work environments, and tacit acceptance of cultural/gender norms.     

The Shifting Subtypes of ADHD: Classification Depends on How Symptom Reports are Combined

Research on the correlates of ADHD subtypes has yielded inconsistent findings, perhaps because the procedures used to define subtypes vary across studies. We examined this possibility by investigating whether the ADHD subtype distribution in a community sample was sensitive to different methods for combining informant data. We conducted a study to screen all children in grades 1-5 (N = 7847) in a North Carolina County for ADHD. Teachers completed a DSM-IV behavior rating scale and parents completed a structured telephone interview. We found substantial differences in the distribution of ADHD subtypes depending on whether one or both sources were used to define the subtypes. When parent and teacher data were combined, the procedures used substantially influenced subtype distribution. We conclude the ADHD subtype distribution is sensitive to how symptom information is combined and that standardization of the subtyping process is required to advance our understanding of the correlates of different ADHD subtypes.     

Suicidality in Bipolar Disorder: The Role of Emotion‐Triggered Impulsivity

A growing body of research suggests that impulsive responses to emotion more robustly predict suicidality than do other forms of impulsivity. This issue has not yet been examined within bipolar disorder, however. Participants diagnosed with bipolar I disorder (n = 133) and control participants (n = 110) diagnosed with no mood or psychotic disorder completed self‐report measures of emotion‐triggered impulsivity (Negative and Positive Urgency Scales) and interviews concerning lifetime suicidality. Analyses examined the effects of emotion‐triggered impulsivity alone and in combination with gender, age of onset, depression severity, comorbid anxiety, comorbid substance use, and medication. A history of suicide ideation and attempts, as well as self‐harm, were significantly more common in the bipolar disorder group compared with the control group. Impulsive responses to positive emotions related to suicide ideation, attempts, and self‐harm within the bipolar group. Findings extend research on the importance of emotion‐triggered impulsivity to a broad range of key outcomes within bipolar disorder. The discussion focuses on limitations and potential clinical implications.