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921.
Learning and memory in S100-beta transgenic mice: an analysis of impaired and preserved function 总被引:4,自引:0,他引:4
S100-beta, a calcium-binding astrocytic protein from chromosome 21, has been implicated in CNS function generally and the hippocampus in particular. Elevated levels of S100-beta have been observed reliably in the brains of patients with Alzheimer's Disease and Down Syndrome. Groups of transgenic mice, carrying multiple S100-beta gene copies, and nontransgenic controls were administered a series of behavioral tests (delayed spatial and nonspatial non-matching-to-sample, radial arm maze, socially acquired food preference) that assessed a wide range of cognitive functions. Consistent with the widespread presence of S100-beta throughout the brain, transgenic mice exhibited learning or memory impairment on all tasks. The dementia-like cognitive profile of S100-beta mice represents a promising model for studying comparable cognitive deficits associated with neurodegenerative diseases. 相似文献
922.
Efforts to explain why some neuropsychologists are more accurate than others have been unsuccessful. In the present study, the relation between the cognitive complexity of clinicians and the validity of their judgments was investigated. Forty-two neuropsychologists completed a measure of cognitive complexity. The hypothesis that neuropsychologists who are high in cognitive complexity will be more accurate than those who are low in cognitive complexity was not supported. It is not clear why cognitive complexity was not significantly related to the validity of diagnostic ratings: One explanation is that the measure of cognitive complexity used in this study was inadequate but another possibility is that neuropsychologists who are low in cognitive complexity may still be able to achieve high levels of accuracy if they attend to normative data when they interpret test results. 相似文献
923.
Studies on MMPI and MMPI-2 malingering indexes often sacrifice generalizability in an attempt to control internal validity. This study improves external validity while still maintaining internal validity by providing graduate student participants with a realistic context for malingering on the MMPI-2 (n=94) and MMPI (n=30). Contextual parameters include a realistic life predicament, psychological knowledge, an incentive, the presence versus absence of a specific diagnosis, and a caution to be realistic. This study found that cautioning participants not to overexaggerate their responses significantly improves their ability to evade detection on the MMPI-2 and MMPI. Standard malingering indexes (Infrequency, F; Back Side, F, Fb; F-Correction, F-K; and Infrequency-Psychopathology, F(p)) were insufficiently sensitive in identifying simulators using common cutoff scores for these cautious simulators. 相似文献
924.
Actors vocally portrayed happiness, sadness, anger, fear, and disgust with weak and strong emotion intensity while reading brief verbal phrases aloud. The portrayals were recorded and analyzed according to 20 acoustic cues. Listeners decoded each portrayal by using forced-choice or quantitative ratings. The results showed that (a) portrayals with strong emotion intensity yielded higher decoding accuracy than portrayals with weak intensity, (b) listeners were able to decode the intensity of portrayals, (c) portrayals of the same emotion with different intensity yielded different patterns of acoustic cues, and (d) certain acoustic cues (e.g., fundamental frequency, high-frequency energy) were highly predictive of listeners' ratings of emotion intensity. It is argued that lack of control for emotion intensity may account for some of the inconsistencies in cue utilization reported in the literature. 相似文献
925.
Benefits are often extended over time. One determinant of this benefit duration is how long a person will live to enjoy them. In four studies, we investigated whether people are sensitive to age when pricing benefits that will last for the remainder of one's life. In Study 1 drivers gave their willingness-to-pay (WTP) to cure a medical condition which would stop them from driving. Results showed an age-embedding effect: WTP was unrelated to the estimated number of driving years left. Study 2 tested whether age-embedding arose because people have a lot of information about themselves which dilutes the impact of age on their valuations. In Studies 3 and 4 we investigated whether people believed that age was an important consideration, or if they failed to properly incorporate it into their judgment. Results indicate that little weight is given to age when making individual pricing decisions, although people did not believe it was normatively irrelevant. 相似文献
926.
The possible benefits of including referring professionals in the first family interviews are being explored as a way to engage refugee families in therapy. Families in exile confront a number of problems related both to premigration traumatic exposures and to present adaptation processes. Refugee clients and the referring professionals in the larger system frequently see the problems and their solutions quite differently. This situation may often result in unclear working alliances in a context of therapy. We will describe first family interviews in which referring professionals are interviewed about their reasons for referrals, and where the families are invited to discuss these considerations. The conversations permit families, referrers, and therapists to reflect upon differences in positions and perspectives. Their experiences suggest that agreements or contracts based on these joint interviews are less ambiguous and more clearly formulated than contracts based on interviews with families alone. Finally, these experiences are discussed as a potentially valuable approach in a cross-cultural context. 相似文献
927.
A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder 总被引:18,自引:0,他引:18
Willcutt EG Pennington BF Boada R Ogline JS Tunick RA Chhabildas NA Olson RK 《Journal of abnormal psychology》2001,110(1):157-172
This study used a nonreferred sample of twins to contrast the performance of individuals with reading disability (RD; n = 93), attention-deficit/hyperactivity disorder (ADHD; n = 52), RD and ADHD (n = 48), and neither RD nor ADHD (n = 121) on measures of phoneme awareness (PA) and executive functioning (EF). Exploratory factor analysis of the EF measures yielded underlying factors of working memory, inhibition, and set shifting. Results revealed that ADHD was associated with inhibition deficits, whereas RD was associated with significant deficits on measures of PA and verbal working memory. The RD + ADHD group was most impaired on virtually all measures, providing evidence against the phenocopy hypothesis as an explanation for comorbidity between RD and ADHD. 相似文献
928.
Understanding memory processes in social anxiety is important because these individuals often report negative memories of anxiety-provoking situations and because of the recent emphasis on learning and memory in models of anxiety. The authors examined the effect of learning on memory for negative social, positive social, and nonsocial information using the retrieval-induced forgetting paradigm in individuals with generalized social phobia (GSPs) and in nonanxious controls (NACs). Words were presented in 1 of 3 practice conditions: practiced words from a practiced category, unpracticed words from a practiced category, and unpracticed words from an unpracticed category. GSPs and NACs showed the same patterns of memory for practice categories for positive social and nonsocial words. However, for negative social words, GSPs benefited less from practice and were hurt less from the effect of practicing competing negative social information than were NACs. This pattern of processing may hamper GSPs' learning of, and habituation to, negative social information. 相似文献
929.
"What else could he have done?" Creating false answers in child witnesses by inviting speculation. 总被引:2,自引:0,他引:2
In 2 experiments (N = 111 children), a suggestive technique for interviewing child witnesses called "inviting speculation" was examined. Children were presented with atypical actions for common objects in a clown show. One week later, the children were asked to speculate (e.g., "What else could he have done with the knife?") in a between-subjects design on all or none of the items (Experiment 1) and in a within-subjects design on part of the items (Experiment 2), thereby getting highly probable speculations (e.g., "to cut"). After a 3-week delay, the experimenters found more highly probable but not more other false answers for the experimental items (Experiment 2). After a 5-6-month delay, the rate of (unspecified) false answers increased compared with the baseline (Experiments 1 and 2). The short-term effect is explained by a speculation-as-misinformation assumption, whereas the long-term effect is explained by the use of a metastrategy. 相似文献
930.
The relative order of an auditory sequence can be more difficult to apprehend when it is presented repeatedly without pause (i.e., cycling) than when it is presented only once (Warren, Obusek, Farmer, & Warren, 1969). We find that this phenomenon, referred to as the midstream order deficit (MOD), can also occur with visual stimuli. The stimuli need not form separate perceptual "streams," and the effect can occur with presentation rates as slow as five items per second, even though the identification of individual letters is very accurate at this rate. However, if the first item of the sequence is visually very distinct from the preceding items, relative order reports can be as accurate in the cycling condition as in the single-presentation condition. Our results suggest that the MOD is not due to masking, attentional blink, repetition blindness, Reeves and Sperling's (1986) order illusion, memory limitations, or decision criteria. The MOD may reflect an attentional cost to the initiation of order encoding, which is distinct from the allocation of attention is required in order to detect and identify individual items. To initiate order encoding successfully, one's attention must be set for, or captured by, an initial salient event. 相似文献