Delaying approval of a critical drug: Safety,efficacy, economics,compassion

Biotechnological advance is speeding the development of drugs. The approval processes for new drugs will inevitably involve a regulatory agency in making political-economic and scientific choices. Interests of specific patients and the public in general are to be considered, and enormous stakes are involved for companies concerned. A medical regulatory authority must be at once insulated from and responsive to many different mixes of singular and general interests and pressures. Access to new drugs can be spurred by the press of patient advocacy groups, but if there are well organized groups to monitor the testing and approval process for such as AIDS or cancer drugs there is often no similar group to represent patient needs. If there is no organized patient advocacy group, compassionate responsibility by a medical regulatory authority is indeed called for. Delay in the approval of new drugs for fighting severe blood infections raises the question of how to insure the compassionate responsibility of a regulatory authority.     

Parental reports of executive dysfunction in adolescents with bipolar disorder.

Bipolar disorder (BPD) is a serious mental illness that affects children and adolescents at a rate similar to that seen in adults. Extremely little is known, however, about cognitive functioning in childhood and adolescent BPD. The present study represents an initial effort to examine executive functioning in adolescents with BPD who are in a manic or mixed mood state, by collecting data from caregivers about the participants' performance on everyday tasks thought to be mediated by executive functioning abilities, using the Behavior Rating Inventory of Executive Function. In comparison to healthy volunteers, adolescents with BPD exhibited significant elevations across all of the measured functional domains. These elevations were evident even in adolescents with BPD who did not have comorbid ADHD, although they were most prominent in those with comorbidity. The findings suggest that adolescents with BPD have functional deficits on tasks requiring executive functioning skills that are not explicable solely on the basis of comorbid ADHD.     

Youth Self-Views,Coping with Stress,and Behavioral/Emotional Problems: The Role of Incremental Self-Theory

Previous research has established associations between stress and coping processes and internalizing and externalizing problems among adolescents and emerging adults. The purpose of the present study was to integrate this literature with research demonstrating the importance of self-theory—views that individuals hold about themselves and their abilities. We examined the extent to which self-theory may influence both coping processes and internalizing and externalizing problems among adolescents and emerging adults. Using moderated mediation, we tested whether coping serves as a mechanism through which self-theory of both intelligence and personality influences internalizing and externalizing problems among adolescents and emerging adults. One hundred and forty participants (adolescents aged 14–17; emerging adults aged 18–30; 60 % female; 8.5 % ethnic minority) completed questionnaires on self-theory, coping responses, and behavioral/emotional problems. Results of moderated mediation analyses were consistent with coping as a mechanism through which self-theory influences psychopathology symptoms such that more malleable beliefs are associated with increased productive coping strategies and lower levels of internalizing and externalizing problems. The current findings also indicate that these associations were significant for adolescents but not for emerging adults. Although cross-sectional, findings suggest that fostering malleable beliefs among adolescents may increase the use of productive coping strategies and positively influence adjustment.     

Baby X

The present study investigated adult behavior while interacting with a three-month-old infant under conditions in which the child was introduced as a boy, as a girl, or with no gender information given. Gender labels did not elicit simple effects, but rather interacted significantly with the sex of the subject on both toy usage and physical contact measures. There was a stronger tendency for both male and female adults to utilize sex-stereotyped toys when the child was introduced as a girl. Most of the findings, however, reflected a differential response of men and women to the absence of gender information. In this condition, male subjects employed a neutral toy most frequently and handled the child least; in contrast, females used more stereotyped toys and handled the child more. All subjects attempted to guess the gender of the child (with “boy” guesses more frequent, although the child was actually female) and all justified their guess on the basis of stereotyped behavioral or physical cues like strength or softness.     

On not knowing what or who one is: Reflections on the intelligibility of dualism

Beginning with Descartes' caution not imprudently to take some other object in place of myself, I consider first the problems of self-identification confronted by variousamnesiacs, both ordinary and Cartesian. Noting thatcogitationes as such do not individuate, I proceed to examine conclusions drawn from certain sorts of body-switching thought experiments. This, in turn, gives rise to a general critique of psychological connectedness or unity of consciousness as a candidate criterion of personal identity. I conclude that our ability to apply any notion of personal identity is parasitic upon the existence of a conceptual apparatus for individuating, identifying, and reidentifying objects. Finally, I argue that, if person is a proper sortal predicate to begin with, Descartes'res cogitans cannot be understood as a species of the (metaphysical) genusres, distinct fromres extensa and only problematically in interaction with it. Cartesian dualism is a multiply untenable doctrine.     

Family therapy alone is not enough or the dirty story of Dorian

When serious malfunctioning of an individual occurs in a secondary system (school, hospital, rehabilitation center, dormitory setting), the tendency often is to focus on the family as both the cause of the malfunctioning and the arena of intervention. Many times, family therapy alone is not enough because a parallel destructive constellation has formed around the Identified Patient in the secondary system as well and the symptoms catalyze that system's own maladaptive patterns. Often the IP is caught in the web of rigid pathological patterns of interactions between the two systems. A unique model of conjoined intersystemic intervention for dealing with such resistance to change is presented.