Breast and Ovarian Cancer: The Forgotten Paternal Contribution

Five to 10% of all cases of breast and ovarian cancer are attributed to a heritable genetic predisposition. Transmission of BRCA1 and BRCA2 mutations is equally likely through maternal or paternal lineage; however, fewer referrals to cancer genetics clinics appear to be made for a paternal, than maternal, family history of breast and/or ovarian cancer. To examine this potential bias, a retrospective review of 315 patient and family charts was conducted by one familial cancer clinic in Toronto, Canada. Referral letters, risk estimates, and family histories were analyzed to identify significant differences between patients referred with maternal and paternal family histories. It was determined that patients are approximately five times more likely to be referred with a maternal family history of breast and/or ovarian cancer as compared to those with a paternal family history (p = <.0001). Individuals with a paternal family history were found to have a different, and higher, pattern of risk estimates (p = .00064). No significant difference was seen between the type of referrals sent by general practitioners, oncologists, and gynecologists. Recommendations to increase the awareness of paternal family history in assessing cancer risk are provided.     

Parallel associative processing in the dorsal striatum: segregation of stimulus-response and cognitive control subregions

Although evidence suggests that the dorsal striatum contributes to multiple learning and memory functions, there nevertheless remains considerable disagreement on the specific associative roles of different neuroanatomical subregions. We review evidence indicating that the dorsolateral striatum (DLS) is a substrate for stimulus–response habit formation – incremental strengthening of simple S–R bonds – via input from sensorimotor neocortex while the dorsomedial striatum (DMS) contributes to behavioral flexibility – the cognitive control of behavior – via prefrontal and limbic circuits engaged in relational and spatial information processing. The parallel circuits through dorsal striatum interact with incentive/affective motivational processing in the ventral striatum and portions of the prefrontal cortex leading to overt responding under specific testing conditions. Converging evidence obtained through a detailed task analysis and neurobehavioral assessment is beginning to illuminate striatal subregional interactions and relations to the rest of the mammalian brain.     

Managing a new collaborative entity in business organizations: understanding organizational communities of practice effectiveness

Companies worldwide are turning to organizational communities of practice (OCoPs) as vehicles to generate learning and enhance organizational performance. OCoPs are defined as groups of employees who share a concern, a set of problems, or a passion about a topic and who strengthen their knowledge and expertise by interacting on a consistent basis. To date, OCoP research has drawn almost exclusively from the community of practice (CoP) literature, even though the organizational form of CoPs shares attributes of traditional CoPs and of organizational teams. Drawing on Lave and Wenger's (1991) original theory of legitimate peripheral participation, we integrate theory and research from CoPs and organizational teams to develop and empirically examine a model of OCoP effectiveness that includes constructs such as leadership, empowerment, the structure of tasks, and OCoP relevance to organizational effectiveness. Using data from 32 OCoPs in a U.S.-based multinational mining and minerals processing firm, we found that external community leaders play an important role in enhancing OCoP empowerment, particularly to the extent that task interdependence is high. Empowerment, in turn, was positively related to OCoP effectiveness. We also found that OCoPs designated as "core" by the organization (e.g., working on critical issues) were more effective than those that were noncore. Task interdependence also was positively related to OCoP effectiveness. We provide scholars and practitioners with insights on how to effectively manage OCoPs in today's organizations.     

Assessing the impact of common method variance on higher order multidimensional constructs

Researchers are often concerned with common method variance (CMV) in cases where it is believed to bias relationships of predictors with criteria. However, CMV may also bias relationships within sets of predictors; this is cause for concern, given the rising popularity of higher order multidimensional constructs. The authors examined the extent to which CMV inflates interrelationships among indicators of higher order constructs and the relationships of those constructs with criteria. To do so, they examined core self-evaluation, a higher order construct comprising self-esteem, generalized self-efficacy, emotional stability, and locus of control. Across 2 studies, the authors systematically applied statistical (Study 1) and procedural (Study 2) CMV remedies to core self-evaluation data collected from multiple samples. Results revealed that the nature of the higher order construct and its relationship with job satisfaction were altered when the CMV remedies were applied. Implications of these findings for higher order constructs are discussed.     

Asymmetry in human cognition: further replication and extension

Vladimir Lefebvre proposed an algebraic model of self-reflexion in the 1980s. He viewed reflexion as a product of the structure and computational rules of Gamma algebra and his equations are considered metaphors for how consciousness is structured. From the framework of this model, Lefebvre hypothesized an asymmetry in human cognition. One of the early studies supporting his model was conducted by Victorina Lefebvre. Over the years, other studies have been conducted, but not all have shown similar support as the original findings of Victorina Lefebvre. This study attempted to extend her findings in testing whether or not other ambiguous stimuli could be used in support of the model.     

Can Social Supports Be Engineered? An Example from the Army's Unit Manning System1

The purpose of the study was to examine variables which lead to the perception of instrumental social support among military wives. More specifically, we were interested in two factors: (a) the Unit Manning System, a method of deployment which keeps groups of soldiers and their families together for long periods of time; and (b) husbands' ranks. Both factors were found to be significant predictors of support in a previous study. Using a path analytic model, we demonstrated that being an officer's wife was related to perceived social support only indirectly through its influence on degree of participation in wives' group activities. Participation in the Unit Manning System also had only an indirect influence on social support. Reasons for these findings are discussed with reference to theories about coping and coping assistance.     

Training community residential staff: Evaluation and follow-up

The purpose of this study was to evaluate the effect of a comprehensive residential direct-care staff training program on staff knowledge, record keeping, habilitation delivery, and turnover. A 40-hour training course was presented to 18 direct-care staff employed in three community residential facilities (CRF), while 18 staff in three other CRFs were placed on a waiting list. Sixteen of 18 trained staff (89%) increased use of habilitation activities, averaging 35.44% programming after training. Only six (33%) of the staff on the waiting list increased programming. The effectiveness of training was assessed against the gains of developmentally disabled (DD) consumers. In the training group, 31 of 36 (86.11%) residents increased on-task behavior while only 7 of 22 (31.6%) of the waiting list residents increased on-task behavior. Training also yielded improved client program records and a 50% decrease in staff turnover. Follow-up over 12 months showed behavior maintenance. Results suggest that training based on clear learner objectives, presented using behavioral procedures, and taught to the entire staff including managers improves staff performance and client benefit.     

The effects of unstable clients in adolescent treatment: contagion versus continuity

This study examined the effects of integrating an unstable group of seriously disturbed adolescents into an existing day treatment program. Behavioral data were collected for an established group of subjects who were in treatment one year prior to and one year after the arrival of a new group of severely disturbed adolescents. It was found that the disruptive behavior displayed by the new admission subjects was not imitated by the subjects of the established group. Rather, there was a significant decrease in aggression and in the overall number of psychiatric events for the established group. The treatment milieu was seen to be resistant to the effects of the new admissions largely due to the structured form of treatment.     

Reactions of would-be helpers whose offer of help is spurned

An experiment was conducted to test the proposition that rejection of help by a needy recipient constitutes a negative expectancy violation for the would-be helper. The helper will react to this self-threat by expressing negative affect, unfavorable evaluations of the recipient, low attraction to the recipient, and causal attributions for the rejection that cast the recipient in an unflattering light. To test these hypotheses, college freshmen were prompted to offer rules for word construction to a same-sex recipient (a confederate) who was described as needing remediation on vocabulary and who "failed" a practice task. After rejecting/accepting the help, the recipient failed or succeeded on a comparable task. The results were consistent with these predictions. Dispositionally high expectations of interpersonal success served to amplify helpers' reactions to rejection/acceptance.