Aspirin Use is Associated with Lower Prostate Cancer Risk in Male Carriers of BRCA Mutations

Previous studies have shown that male BRCA mutation carriers stand at increased risk of developing prostate cancer and have concerns about developing cancer. Genetic counseling practitioners often discuss strategies for reducing the risk of cancer for patients at high risk due to their genetic background. Addressing modifiable health habits is one such strategy. Unfortunately, modifiable risk factors for prostate cancer have only been documented in the general population and have not yet been studied in the BRCA carrier subpopulation. Therefore, this study aimed to identify modifiable risk factors for prostate cancer in BRCA carriers. We examined prostate cancer risk factors in 74 men who were part of families with a BRCA mutation. This study examined nine dichotomous variables including: exercise, history of vasectomy, smoking history, alcohol use, finasteride use, statin use, aspirin use, coffee use, and vitamin use. The survey was sent to all cases of prostate cancer in the Hereditary Cancer Center Database at Creighton University with a known BRCA status. This study confirmed the protective benefits of daily aspirin use, which have been observed in previous studies of the general population, and suggests its benefit in BRCA carriers. Protective benefits from regular vigorous exercise and daily coffee use trended towards significance, but neither factor withstood the Bonferroni Correction for multiple comparisons.     

The Mystical and the Material: Slavoj Žižek and the French Reception of Mysticism

This paper will argue that the work of Slavoj ?i?ek can be fruitfully understood as a response to mystical theology as it has been received in two strands of 20th century French thought—psychoanalysis and phenomenology—and that ?i?ek's work in turn offers intriguing possibilities for the re-figuring of mystical theology by feminist philosophy of religion. Twentieth century French psychoanalysis is dominated by the work of Jacques Lacan and by his students Julia Kristeva and Luce Irigaray. All three of these figures engage in significant ways with mystical theology—particularly with the works and figures of female mystics—as a crucial resource for theorising gender and subjectivity. A second strand of the 20th century French reception of mystical theology is the phenomenological tradition, specifically the work of Jacques Derrida. This paper will argue that, drawing on and challenging both of these elements of recent French engagement with mystical theology, ?i?ek's work offers a materialist ontology which seeks to locate transcendence within immanence and materiality, offering to feminist philosophy of religion the resources for re-thinking the relationship of the mystical to the material.     

Post hoc versus predictive accounts of children’s theory of mind: A reply to Ruffman

Ruffman (2014) argues for a minimalist account of infants’ performance on theory of mind tasks. This commentary argues that because Ruffman’s minimalist account is post hoc, it neither generates testable predictions about how infants will respond in new situations, nor does it offer a coherent explanation for existing false-belief findings. An alternative, mentalist account is presented. This account integrates infancy findings with prior theory of mind literature and generates novel predictions about children’s false belief performance.     

Vagueness and Context

A number of recent accounts for vague terms postulate a kind of context-sensitivity, one that kicks in after the usual ‘external’ contextual factors like comparison class are established and held fixed. In a recent paper, ‘Vagueness without Context Change’(Mind 116 (2007): 275–92), Rosanna Keefe criticizes all such accounts. The arguments are variations on considerations that have been brought against context-sensitive accounts of knowledge, predicates of personal taste, epistemic modals, and the like. The issues are well known and there are variety of options available in reply. More important, the arguments rely on an overly narrow conception of context-sensitivity, suggesting that one size fits all. If Keefe’s arguments were cogent, they would tell against the context-sensitivity of just about any expression, beyond the typical indexicals, including the variation of vague terms with comparison class. However, the criticisms raised by Keefe do highlight certain questions that must be answered by an advocate of a context-sensitive account of vagueness, essentially the same sorts of questions that must be answered by a contextualist or relativist about knowledge, epistemic modals, predicates of personal taste, etc. The main purpose of this paper is to use replies to the relevant objections raised by Keefe as a springboard for further articulation of the underlying view of vagueness.     

The hard problem of intertheoretic comparisons

Philosophical Studies - Metanormativists hold that moral uncertainty can affect how we ought, in some morally authoritative sense, to act. Many metanormativists aim to generalize expected utility...     

The invention of uncertainty in American psychology: intellectual conflict and rhetorical resolution, 1890-1930

A sharp and personal polemical style characterized psychology as a new human science in American universities at the turn of the 20th century. When the experimental pursuit of truth about the mind produced quarreling rather than clarity, psychologists experienced a crisis of confidence. One solution was rhetorical: the use of a disclaimer that all current knowledge was rudimentary and a call for further research to end contention. The wording established a public tone of modesty and fostered collegiality. Scientific disagreements and underlying personal tensions remained, but conventional phrases promising future resolution of disputes contributed to a language of good manners and thereby facilitated debate. Nonetheless, the verbal formula of deferred hopes also made uncertainty seem normative. Confessions of tentativeness helped lay a historical foundation for routine investigation in psychology, but emphasis on incompleteness as an explanation of discord also made experimentation seem perpetual and truth elusive.     

The impact of depressive symptomatology on risky sexual behavior and sexual communication among African American female adolescents

Adolescents, particularly African American adolescents, are at high risk for sexually transmitted infections (STIs). The association between psychosocial factors and risky sexual behavior has been well established. However, only a small number of studies have examined the relationship between depressive symptomatology among African American female adolescents, specifically over time. The present study examined depressive symptoms as a predictor of risky sexual behavior, sexual communication, and STIs longitudinally among African American female adolescents between the ages 15 and 21. Binary generalized estimating equation models were conducted assessing the impact of depressive symptoms at baseline on risky sexual behavior and STIs over six- and 12-months follow-up. Age, intervention group, and baseline outcome measures were entered as covariates. The results indicated that high levels of depressive symptoms predicted no condom use during last sexual encounter and multiple sexual partners over six-months follow-up. Depressive symptoms also predicted having a main partner with concurrent partners, high fear of communication about condoms, and sex while high on alcohol or drugs over six- and 12-months follow-up. These findings could be used to inform HIV/STI prevention intervention programs and clinicians providing regular health care maintenance to African American female adolescents engaging in risky sexual behavior.     

Modeling a cascade of effects: the role of speed and executive functioning in preterm/full-term differences in academic achievement

This study identified deficits in executive functioning in pre-adolescent preterms and modeled their role, along with processing speed, in explaining preterm/full-term differences in reading and mathematics. Preterms (< 1750 g) showed deficits at 11 years on a battery of tasks tapping the three basic executive functions identified by Miyake - updating/working memory, inhibition, and shifting. Confirmatory factor analysis showed that these executive functions, though correlated, were distinct from one another and from processing speed, which later proved to account for much of the intercorrelation among executive functions. In the best-fitting structural equation model, the negative effects of prematurity on achievement were completely mediated by the three executive functions and speed in a cascade of effects: prematurity → slower processing speed → poorer executive functioning (working memory) → lower achievement in math and reading.