Sequence-Specific Impairment of Memory Formation by NCAM Antisense Oligonucleotides

The functional role of NCAM gene expression in memory formation was studied in the one-trial passive avoidance task in day-old chicks by pretraining injections of one of three different 18-mer end-protected oligonucleotides corresponding to positions 190-, 207-, and 332- of the NCAM Ig1 domain. Twenty-four-hour-old chicks were trained by pecking at a bitter-tasting bead and tested for avoidance 30 min, 3, 8, or 24 hr later. Memory retention was significantly reduced only in the group of animals injected with the NCAM antisense corresponding to position 207- (AS-ODN-207), and only if given twice, both immediately after hatching and 12 hr before training. This antisense was without effect on the general behavior of the chicks, training or acquisition, and did not produce observable neurotoxic damage. Under such conditions amnesia was evident by 3 hr after training and lasted until at least 24 hr after training. The two other tested oligonucleotides were without behavioral effect. To control for nonsequence-specific effects of AS-ODN-207, brains from injected and trained animals were processed for Western blotting and probed using anti-NCAM, anti-L1, and anti-actin antibodies. NCAM antisense corresponding to position 207- significantly reduced the level of NCAM, whereas the level of L1 and actin remained unchanged. These results confirm our earlier conclusion that NCAM is necessary for longer term memory retention.     

Frequency judgements: the problem of defining a perceptual event

In four experiments the conditions under which frequency judgments reflect the relative frequency of complex perceptual events were explored. Subjects viewed a series of 4 x 4 grids each containing seven items, which were letters and numbers in one of four typefaces. Later judgments of the relative frequency with which particular letters appeared in particular typefaces were unaffected by a warning about an upcoming frequency judgment task, but were affected by both the time available for processing the stimuli and the nature of the cover task subjects engaged in while viewing the grids. Frequency judgments were poor when exposure durations were less than 2 s and when the cover task directed subjects' attention merely to the locations of the items within the grids. Frequency judgments improved when the cover task directed subjects' attention to the identity of the stimuli, especially to the conjunction of letter and typeface. The results suggest that frequency estimation of complex stimuli may be possible only for stimuli that have been processed as phenomenal objects.     

Book reviews

Hall, G. (1991). Perceptual and associative leaning. Oxfod: Clarendon Press. Pp. xi + 300. ISBN 0-19-8524182-0. £35.00.

Rahmann, H., & Rahmann, M. (1992). The neurobilogical basis of memoy and behavior. New York: Springe Verlag. Pp. 292. ISBN 3-540-97545-4. £53.00.

Iversen, I.H., & Lattal, K.A. (Eds.). (1991). Experimental analysis of behavior, arts 1 and 2. Techniques in the behavioral and neural sciences, volume 6 (series editor: J.P Huston). Amstedam: Elsevier. Pp. 724. ISBN 0-444-8932-2. £50.00 (paperback).

Baudry, M., & Davis, J.L. (Eds.) (1991). Long-tem potentiation: A debate of current issues. Cambridge, Ma & London, England: MIT Press. Pp. xxii + 454. ISBN 0-262-02330-x. £62.95 (Hb).

The Biological Council Animal Reseach and Welfare Panel (1992). Guidelines on the handling and training of laboatory animals. Univer-sities Federation for Animal Welfare. Pp. ISBN 0-900767-77-4. £2.50.     

Sensitive Topics,Missing Data,and Refusal in Social Network Studies: An Ethical Examination

We describe our ethics‐driven process of addressing missing data within a social network study about accountability for racism, classism, sexism, heterosexism, cis‐sexism, ableism, and other forms of oppression among social justice union organizers. During data collection, some would‐be participants did not return emails and others explicitly refused to engage in the research. All refusals came from women of color. We faced an ethical dilemma: Should we continue to seek participation from those who had not yet responded, with the hopes of recruiting more women of color from within the network so their perspectives would not be tokenized? Or, should we stop asking those who had been contacted multiple times, which would compromise the social network data and analysis? We delineate ways in which current discussions of the ethics of social network studies fell short, given our framework and our community psychology (CP ) values. We outline literature that was helpful in thinking through this challenge; we looked outside of CP to the decolonization literature on refusal. Lessons learned include listening for the possible meanings of refusals and considering the level of engagement and the labor required of participants when designing research studies.     

Differential effects of arousal in positive and negative autobiographical memories

Autobiographical memories are characterised by a range of emotions and emotional reactions. Recent research has demonstrated that differences in emotional valence (positive vs. negative emotion) and arousal (the degree of emotional intensity) differentially influence the retrieved memory narrative. Although the mnemonic effects of valence and arousal have both been heavily studied, it is currently unclear whether the effects of emotional arousal are equivalent for positive and negative autobiographical events. In the current study, multilevel models were used to examine differential effects of emotional valence and arousal on the richness of autobiographical memory retrieval both between and within subjects. Thirty-four young adults were asked to retrieve personal autobiographical memories associated with popular musical cues and to rate the valence, arousal and richness of these events. The multilevel analyses identified independent influences of valence and intensity upon retrieval characteristics at the within- and between-subject levels. In addition, the within-subject interactions between valence and arousal highlighted differential effects of arousal for positive and negative memories. These findings have important implications for future studies of emotion and memory, highlighting the importance of considering both valence and arousal when examining the role emotion plays in the richness of memory representation.     

Attachment Theory and Mindfulness

We initiate a dialog between two central areas in the field of psychology today: attachment theory/research and mindfulness studies. The impact of the early mother-infant relationship on child development has been well established in the literature, with attachment theorists having focused on the correlation between a mother’s capacity for self-regulation and connection (e.g., attunement) with children’s health and developmental outcomes. Because the transition to parenthood is often a stressful one, research has also focused on the importance of the mother’s external and internal support (e.g., self-awareness, recognition of needs) in promoting healthy mother-infant relationships. One promising field in relation to increased internal support is mindfulness, a practice shown to increase emotional regulation while decreasing stress and anxiety. Described as non-judgmental, present-moment awareness, mindfulness has received significant empirical attention over the past three decades and has recently been theorized as an important contributing factor in healthy mother–child relationships. Recognizing the potentially beneficial effects of mindfulness training on healthy attachment, this article reviews relevant literature in presenting a case for exploratory and empirical research into the dynamic relationship between mindfulness, attachment style, maternal health, and children’s development. Grounds for this convergence, as well as suggestions for future research, are presented.     

Being mixed: who claims a biracial identity?

What factors determine whether mixed-race individuals claim a biracial identity or a monoracial identity? Two studies examine how two status-related factors-race and social class-influence identity choice. While a majority of mixed-race participants identified as biracial in both studies, those who were members of groups with higher status in American society were more likely than those who were members of groups with lower status to claim a biracial identity. Specifically, (a) Asian/White individuals were more likely than Black/White or Latino/White individuals to identify as biracial and (b) mixed-race people from middle-class backgrounds were more likely than those from working-class backgrounds to identify as biracial. These results suggest that claiming a biracial identity is a choice that is more available to those with higher status.     

Pathways to vocational services: factors affecting entry by veterans enrolled in Veterans Health Administration mental health services

The current study provides naturalistic data documenting the pathways-to-care to vocational services for 155 veterans who were receiving some form of mental health care from the Veterans Health Administration and had a vocational need but were not currently enrolled in vocational services. Of the participants, 94.2% had recognized their vocational need, 80.6% reported that they or someone else had sought help to alleviate the need, and 77.4% had previously received some form of vocational services. The median length of the participants' vocational need was more than 4.2 years. Delays associated with recognition, help-seeking, and treatment entry all contributed to the overall delay in entering appropriate care. Filtering factors associated with quicker recognition, seeking help, and receiving services included diagnosis, level of disability, type of vocational need, and support from primary providers, family, and friends. The results provide information for designing interventions to improve service entry by adults with mental health problems and vocational needs.     

Broadening Political Psychology

One hundred years ago, if we proposed that we could make you happy with a pill, we would have been ridiculed and would have entered the realm of science fiction and not science itself. Yet that is precisely where we are today. The genetics and neurobiological revolution is upon us, and we advocate that political psychology not simply join this revolution but take a lead role in it. Here in this review, we explore the various ways in which political psychology can embrace this revolution and incorporate work in neuropsychology, cognitive neuroscience, psychiatry, endocrinology, and recent advances in genetics. In doing so, we advocate the adoption of an epidemiological approach and discuss the ways in which various methods including physiological experimentation, genetic analysis, and neurological explorations including MRIs and other technical advances provide critical insight into human behavior and present intriguing possibilities for exploring the nature of political attitudes, attachments, and behaviors. In advocating for broadening the approaches used in the field, we reflect critically on how we might improve and strengthen the accuracy of our understanding of the psychological bases of political preferences and behavior in the future.