Whose Gene Is It? A Case Discussion About Familial Conflict over Genetic Testing for Breast Cancer

A multidisciplinary group of genetic and other professionals discuss a complex case of familial conflict over access to genetic information. One twin wishes to know the results of her deceased mother's tests for BRCA1 mutations; a second twin objects to researchers making this information available. As the case discussion unfolds, the apparent facts of this case are called into question and the lines of ethical certainty become less clear.     

Implicit learning: Indirect, not unconscious

Dienes and Berry (1997) argue that there really are two kinds of knowledge, implicit and explicit, that can be characterized through a subjective threshold. We argue that the subjective threshold does not separate two forms of knowledge, but instead two uses of knowledge, for two different purposes. With Neal and Hesketh (1997), we suggest that an understanding of learning will be better served by investigating the processing that occurs under various circumstances than by attempting to isolate learning that occurs with awareness from that which occurs without it.     

Building and Maintaining Clinical Programs

This paper describes the basic elements of practice development and management within the academic medical setting. These include assessment of the market environment, both in the community and within the medical setting, product development, marketing, budget basics, quality, managed care negotiations, and finding time to do research in a financially-driven health care system.     

Toward an understanding of psychological burnout among police officers

This study examined a research model developed to understand psychological burnout among police officers. Data were collected from 828 men and women in police work using questionnaires completed anonymously. Five groups of predictor variables identified in previous research were considered: individual demographic and situational variables, work stressors, stressful events, work-family conflict and coping responses. Sources of stress (chronic stressors, stressful events, work-family conflict) were significantly related to levels of psychological burnout when individual demographic and situational variables were controlled.     

Use and misuse of metrics in research evaluation

This paper addresses some critical issues in the applicability of quantitative performance measures (including bibliometric, economic, and co-occurrence measures) to the assessment of basic research. The strengths and weaknesses of metrics applied as research performance measures are examined. It is concluded that metrics have a useful role to play in the evaluation of research. Each metric employed, whether bibliometric, economic, co-occurrence, or others, brings a new dimension of potential insight to the complex problem of research assessment. However, when used in a stand-alone mode, metrics can be easily misinterpreted and result in misleading conclusions. Metrics should be an integral part of a more comprehensive approach to research evaluation, in which the leading role is assumed by expert peer review. Under this structure, the reviewers must be broadly constituted, so that the technical correctness of the research approaches being taken (doing the job right) can be evaluated by technical experts and the correctness of the research target (doing the right job) can be evaluated as well. This comprehensive approach insures quality in the implementation of existing research paradigms and allows the introduction of revolutionary new research paradigms as well. The views contained in this paper are solely those of the author and do not represent the views of the Department of the Navy. Ronald Kostoff received a Ph.D. from Princeton University, performed technical and economic research at Bell Laboratories, managed energy programs at U.S. Department of Energy, was Director of Technical Assessment at the Office of Naval Research for many years and presently manages the Navy’s In-House Laboratory Independent Research Program.     

A human-centered approach for designing World-Wide Web browsers

Because the World-Wide Web has features that are not found in traditional information systems, it has some unique problems pertaining to human use, such as the difficulty of searching for specific information. This paper describes human cognitive limitations pertinent to the design of Web browsers and provides a conceptual model for human information processing on the Web. It also compares user strategies and use of browser functions for two tasks that differ in the specificity of the information that is to be retrieved. General principles and specific recommendations for the design of Web browsers are derived from these considerations.     

Spline smoothing with model-based penalties

Nonparametric regression techniques, which estimate functions directly from noisy data rather than relying on specific parametric models, now play a central role in statistical analysis. We can improve the efficiency and other aspects of a nonparametric curve estimate by using prior knowledge about general features of the curve in the smoothing process. Spline smoothing is extended in this paper to express this prior knowledge in the form of a linear differential operator that annihilates a specified parametric model for the data. Roughness in the fitted function is defined in terms of the integrated square of this operator applied to the fitted function. A fastO(n) algorithm is outlined for this smart smoothing process. Illustrations are provided of where this technique proves useful.     

The effect of spatial frequency on global precedence and hemispheric differences

There are many conditions in which identification proceeds faster for the global form of a hierarchical pattern than for its local parts. Since the global form usually contains more lower spatial frequencies than do the local forms, it has frequently been suggested that the higher transmission rate of low spatial frequencies is responsible for the global advantage. There are also functional hemispheric differences. While the right hemisphere is better at processing global information, the left hemisphere has an advantage with respect to local information. In accordance with the spatial-frequency hypothesis, it has been speculated that this difference is due to a differential capacity of the hemispheres for processing low and high spatial frequencies. To test whether low spatial frequencies were responsible for the global advantage and/or for the observed hemispheric differences, two experiments were carried out with unfiltered and highpass-filtered compound-letter stimuli presented at the left, right, or center visual field. The first experiment, in which the target level was randomized in each trial block, revealed that low spatial frequencies were not necessary for either global advantage or for hemispheric differences. Highpass filtering merely increased the response times. In the second experiment, the target level was held constant in each block. This generally increased the speed of responding and produced interactions between filtering and global-local processing. It was concluded that both sensory and attentional or control mechanisms were responsible for global precedence and that the hemispheres differed with respect to the latter.