Clock drawing performance and brain morphology in mild cognitive impairment and Alzheimer's disease

The Clock Drawing Test (CDT) is a widely used instrument in the neuropsychological assessment of Alzheimer's disease (AD). As CDT performance necessitates several cognitive functions (e.g., visuospatial and constructional abilities, executive functioning), an interaction of multiple brain regions is likely. Fifty-one subjects with mild cognitive impairment, 23 with AD and 15 healthy controls underwent high-resolution magnetic resonance imaging. Optimized voxel-based morphometry (VBM) was performed to investigate the putative association between CDT performance and gray matter (GM) density throughout the entire brain. In the first step of analysis (p<.001, uncorrected), VBM revealed a reduced GM density in numerous cortical (temporal lobe, frontal lobe, parietal lobe, cerebellum) and subcortical (thalamus, basal ganglia) brain regions to be associated with poorer CDT performance. When corrected for multiple comparisons (p<.01), the associations remained significant predominantly in the left temporal and--less pronounced--the right temporal lobe. VBM demonstrated CDT performance to depend on the integrity of widely distributed cortical and subcortical areas in both brain hemispheres with accentuation in the left-sided temporal lobe region.     

On the interplay between familiarity and emotional expression in face perception

Traditional models of face perception (e.g. Bruce and Young 1986) stress independent routes for processing identity and emotional expression. We investigated the interplay between familiarity and emotional expression by systematically varying both factors. In contrast to earlier studies which used binary forced-choice decisions, participants had to judge the familiarity of the presented face and the emotional hedonic valence and emotional arousal of its expressed emotion (angry, happy or neutral), using rating scales. The results demonstrated symmetric, strong interactions between familiarity and expressed emotion. Thus, this study supports more recent models of face perception (Haxby et al. 2000) that were mostly based on brain imaging data. These data together with our behavioural results emphasize the interaction of emotional expression and personal identity and support approaches that propose a relative segregation of these processes, rather than completely independent coding (Calder and Young 2005).     

The effects of social influence on children's memory reports: the omission and commission error asymmetry

Children in two age groups (7 vs. 12 yrs, N= 174) individually interacted with a stranger and were later interviewed about this event. Right before the interview, each child encountered the stranger once again and he engaged in a conversation where he either suggested that a (central or peripheral) detail originally present in the event had actually not been there or that an originally non-present (central or peripheral) detail had in fact been there. It was hypothesized that the two types of misinformation would result in omission and commission errors respectively. The results showed that the social influence resulted in an asymmetric effect (i.e., more commission than omission errors). Importantly, we also found that the children made more errors with respect to the peripheral detail (a suitcase), compared to the central detail (a passenger). Younger children did not make more errors (neither omission nor commission errors) than older children.     

The Swedish National Adult Reading Test (NART-SWE): a test of premorbid IQ

The purpose of this study was to construct a Swedish version of the National Adult Reading Test (NART-SWE), a test for assessment of premorbid IQ, and to investigate its validity and reliability on healthy controls and patients with mild Alzheimer's disease. As Swedish pronunciation rules are fixed, NART-SWE was constructed using loan words. NART-SWE has satisfactory psychometric properties: Inter-rater and retest reliability as well as internal consistency are very high. The NART-SWE demonstrates face validity. In addition, high correlation with IQ was obtained. A significant model emerged when using NART-SWE to predict IQ. Furthermore, no significant differences were observed when comparing performance for healthy controls' with that of patients with Alzheimer's disease on NART-SWE. It does appear that reading of irregular words is intact in mild Alzheimer's disease.     

Effects of the premenstrual syndrome on facial expressions of sadness

This study examined the relationship between PMS and emotion-related electromyographic facial activity at different phases of the menstrual cycle. Twenty-four women of reproductive age (12 with PMS, 12 controls) participated in two EMG sessions (T1 and T2) in which they were shown photographic images that can elicit various emotions (IAPS stimuli). T1 took place in the follicular phase, T2 in the luteal phase. The activity of the musculus depressor anguli oris ("depressor", expression of sadness) was measured. Depressor activity was compared to activity of musculus orbicularis oculi ("orbicularis"; expression of joy). ANOVA yielded a significant increase of the activity of the depressor at T2 in the PMS group. The PMS group showed more frequent depressor activity during the luteal than the follicular phase. Orbicularis activity did not change from T1 to T2. Conclusions: The PMS group experienced various visual stimuli in a more depressed way during the luteal phase.     

Examination of the processing speed account in a population-based longitudinal study with narrow age cohort design

The processing speed account suggests that general slowing of mental processing speed results in an overall decline, especially age-related decline, in other cognitive domains. Support for the speed account comes mainly from cross-sectional studies with participants that vary in age (age-heterogeneous samples). This study investigated how well variations in processing speed predict change of episodic recall in a longitudinal framework and examined with the Narrow Age Cohort (NAC) design. Data were obtained from Betula, a population-based longitudinal study. Both 5-year (n= 490; Time 3 - Time 4) and 10-year follow-up results (n= 608; Time 1 - Time 3) were used. In both samples, which were subjected to prospective dementia screening, we found considerably weaker associations in longitudinal data compared to cross-sectional, and also weaker associations in age-homogeneous than in age-heterogeneous samples. The results provide little support for the speed account.     

Cognitive and linguistic skills in Swedish children with cochlear implants - measures of accuracy and latency as indicators of development

The purpose of the present study was to examine working memory (WM) capacity, lexical access and phonological skills in 19 children with cochlear implants (CI) (5;7-13;4 years of age) attending grades 0-2, 4, 5 and 6 and to compare their performance with 56 children with normal hearing. Their performance was also studied in relation to demographic factors. The findings indicate that children with CI had visuospatial WM capacities equivalent to the comparison group. They had lower performance levels on most of the other cognitive tests. Significant differences between the groups were not found in all grades and a number of children with CI performed within 1 SD of the mean of their respective grade-matched comparison group on most of the cognitive measures. The differences between the groups were particularly prominent in tasks of phonological WM. The results are discussed with respect to the effects of cochlear implants on cognitive development.     

Processing modifier-head agreement in reading: Evidence for a delayed effect of agreement

The present study examined whether type of inflectional case (semantic or grammatical) and phonological and morphological transparency affect the processing of Finnish modifier-head agreement in reading. Readers' eye movement patterns were registered. In Experiment 1, an agreeing modifier condition (agreement was transparent) was compared with a no-modifier condition, and in Experiment 2, similar constructions with opaque agreement were used. In both experiments, agreement was found to affect the processing of the target noun with some delay. In Experiment 3, unmarked and case-marked modifiers were used. The results again demonstrated a delayed agreement effect, ruling out the possibility that the agreement effects observed in Experiments 1 and 2 reflect a mere modifier-presence effect. We concluded that agreement exerts its effect at the level of syntactic integration but not at the level of lexical access.     

Severe Life Events and Chronic Adversities as Antecedents to Anxiety in Children: A Matched Control Study

The present study compared the number of severe life events and chronic adversities as reported retrospectively by mothers of children with an anxiety disorder (n = 39) prior to the onset of their most recent episode, with controls (n = 39) matched for age and sex. The parent version of the Psychosocial Assessment of Childhood Experiences (PACE) was used to assess chronic adversities (long-term experiences with negative impact on child) and severe life events (discrete life events with high long-term threat). A significantly greater number of severe life events and chronic adversities were assessed prior to onset for anxious children compared to controls. The finding for severe life events held regardless of whether impact ratings were assigned by mothers or a panel of independent raters, suggesting the findings reflect actual as opposed to perceived differences. Results suggest that both discrete and chronic stressors may constitute risk for future episodes of anxiety in children.

Deliberate self-harm in 14-year-old adolescents: how frequent is it, and how is it associated with psychopathology, relationship variables, and styles of emotional regulation?

Deliberate self-harm was studied in 14-year-old adolescents from four schools in southern Sweden with a test-retest design, using a nine-item version of the Deliberate Self-Harm Inventory. At Time 1, 40.2% of the adolescents indicated deliberate self-harm on at least one occasion compared with 36.5% at Time 2. Test-retest data showed high stability over periods of up to 2 months in duration. Cross-validation of the results from Time 1 to Time 2 showed robust correlations between deliberate self-harm and general psychopathology, a relative absence of positive feelings toward parents, and a ruminative style of emotional regulation. Further, rumination/negative thinking and a relative absence of positive feelings toward parents were predictors of self-harm independently of general psychopathology. In addition, deliberate self-harm correlated with symptoms of eating disorder and negative body esteem in girls.