Sparse but not 'grandmother-cell' coding in the medial temporal lobe

Although a large number of neuropsychological and imaging studies have demonstrated that the medial temporal lobe (MTL) plays an important role in human memory, there are few data regarding the activity of neurons involved in this process. The MTL receives massive inputs from visual cortical areas, and evidence over the last decade has consistently shown that MTL neurons respond selectively to complex visual stimuli. Here, we focus on how the activity patterns of these cells might reflect the transformation of visual percepts into long-term memories. Given the very sparse and abstract representation of visual information by these neurons, they could in principle be considered as 'grandmother cells'. However, we give several arguments that make such an extreme interpretation unlikely.     

Distributional expectations and the induction of category structure

Previous research on how categories are learned from observation of exemplars has largely ignored the possible role of prior expectations concerning how exemplars will be distributed. The experiments reported here explored this issue by presenting subjects with category-learning tasks in which the distributions of exemplars defining the categories were varied. In Experiments 1 and 2 the distributional form of a category was found to affect speed of learning. Learning was faster when a category's distribution was normal than when it was multimodal. Also, subjects in the early stages of learning a multimodal category responded as if it were unimodal. These results suggested that subjects enter category-learning tasks with expectations of unimodal, possibly normal, distributions of exemplars. Experiments 3 and 4 attempted to manipulate subjects' prior expectations by varying the distribution of exemplars in the first of two consecutive category-learning tasks. Learning a multimodal category was influenced by the shape of a previously learned distribution and was facilitated when the earlier distribution was either multimodal or skewed, rather than normal. These results are interpreted as support for a dual-process model of category learning that incorporates the effects of prior expectations concerning exemplar distributions.     

The Expectancy Challenge Alcohol Literacy Curriculum (ECALC): A single session group intervention to reduce alcohol use

The Expectancy Challenge Alcohol Literacy Curriculum (ECALC) is a single session group-delivered program designed to modify alcohol expectancy processes and reduce alcohol use among children and young adults. The objective of this study was to demonstrate the effectiveness of the ECALC in reducing risky alcohol use among heavy drinking college men. Four fraternities at a large state university were randomly assigned to receive either the single session ECALC or a control presentation (2 fraternity houses per condition, n = 250). Alcohol expectancies were assessed before and immediately after program presentation. Results demonstrated significant changes on 5 of the 7 subscales of the Comprehensive Effects of Alcohol Scale (CEOA) among students who received the ECALC when compared with control participants. Alcohol use data were collected for 4 weeks before and 4 weeks after program presentation. Compared with those in the control condition, students who received the ECALC demonstrated significant reductions in all facets of alcohol use measured, including decreased mean and peak blood alcohol content (BAC), decreased mean number of days drinking per week, decreased mean drinks per sitting, and decreased number of binge-drinking episodes per month. This study represents 2 important advances. First is the significant reduction in risky alcohol use produced by a single session group-delivered program. The second important advance is the success in changing expectancy processes without using impractical elements common in previous expectancy challenge methods (e.g., a "barlab" environment and actual alcohol administration). (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Prolegomena to any future mereology of the body

Many bioethical arguments rely implicitly on the assumption that the concept of “human part” is one on which everyone must agree, because it is unambiguous. But various parties interpret this “unambiguous” term in incompatible ways, leading to contention. This article is an informal presentation of a topomereological system on whose preferred interpretation several distinct but related meanings of “human part” can be isolated: part of a human body, part of the completion of a human body, and part of a human being. A case is analyzed (the first total artificial heart (TAH) implantation), demonstrating in the process much of the apparatus of the system. By means of a casuistic methodology, the analysis is translated into recommendations for the ethical conduct of future TAH research. The more general conclusion, however, is that formal methods may provide useful tools for clarifying thought processes and organizing arguments in debates over bioethical issues.     

THE ENCHANTED BEDSIDE

This paper is based on the authors' work offering psychological therapies to patients and their families in a specialist palliative care unit, pre‐ and post‐death. In addressing issues of family interaction around the bedside of the dying patient, the authors have noted a pattern of events that arise from strongly ambivalent relationships.

In particular, family adjustment to the declining health of the patient is acted out in a physical and emotional move around the bedside, with a ‘hierarchy of bereavement’ indicating the status of the relationship to the patient. Previously conflicted feelings towards the dying patient are replaced by an impermeable idealization, lasting throughout bereavement.

In trying to understand this process of idealization the authors have used an analytical frame, referring to Freud and Klein and their work on mourning. This leads on to an exploration of the implications for clinical practice within palliative care. An unshifting idealization can be problematic for many reasons. The reader is left with a discussion about how to work best with families whose initial protective defence can easily crystallize into a long‐term grief reaction.     

Overgeneralization from limited data: A commentary on Cooper et al., 2010

This article comments on a recent paper by Cooper et al. in BRAT. Its main purpose is to comment on the provocative conclusion in the paper that behavioral research on weight loss maintenance should be abandoned. We disagree, arguing that the authors over generalize from their research, under crediting past behavioral weight loss research for its accomplishments, which are considerable. We briefly outline areas we believe remain exciting new research directions in this field.     

Sexual and Violent Media's Inhibition of Advertisement Memory: Effect or Artifact?1

Research ( Bushman, 2005 ; Bushman & Bonacci, 2002 ) has claimed to demonstrate that sexual and violent content in television programs inhibits viewers' memory for advertisements. However, that research failed to adequately control other aspects of the programs' content, making interpretation problematic. The present paper attempts to correct these flaws. Studies 1 and 2 demonstrate that if other aspects of show content are held constant, sex and violence alone do not affect memory for advertisements. Study 3 provides evidence that while sex or violence does not affect memory, other aspects of program content (e.g., plot, humor) do have a significant influence on advertisement memory. Implications of this research on the interpretation of previous research are discussed.