Conditioned fear is modulated by D2 receptor pathway connecting the ventral tegmental area and basolateral amygdala

Excitation of the mesocorticolimbic pathway, originating from dopaminergic neurons in the ventral tegmental area (VTA), may be important for the development of exaggerated fear responding. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. The functional role of the dopaminergic pathway connecting the VTA to the basolateral amygdala (BLA) in fear and anxiety has received little attention. In vivo microdialysis was performed to measure dopamine levels in the BLA of Wistar rats that received the dopamine D(2) agonist quinpirole (1 μg/0.2 μl) into the VTA and were subjected to a fear conditioning test using a light as the conditioned stimulus (CS). The effects of intra-BLA injections of the D(1) antagonist SCH 23390 (1 and 2 μg/0.2 μl) and D(2) antagonist sulpiride (1 and 2 μg/0.2 μl) on fear-potentiated startle (FPS) to a light-CS were also assessed. Locomotor performance was evaluated by use of open-field and rotarod tests. Freezing and increased dopamine levels in the BLA in response to the CS were both inhibited by intra-VTA quinpirole. Whereas intra-BLA SCH 23390 did not affect FPS, intra-BLA sulpiride (2 μg) inhibited FPS. Sulpiride's ability to decrease FPS cannot be attributed to nonspecific effects because this drug did not affect motor performance. These findings indicate that the dopamine D(2) receptor pathway connecting the ventral tegmental area and the basolateral amygdala modulates fear and anxiety and may be a novel pharmacological target for the treatment of anxiety.     

Mechanical output about the ankle in countermovement jumps and jumps with extended knee

In this study the mechanical output (e.g., force, contraction velocity, instantaneous power) about the ankle was measured during a jump with and without occurrence of transportation of power and pre-stretch potentiation. To examine this, a model of the m. triceps surae was used. Eleven subjects performed a maximal one-legged countermovement jump (CMJ) and a maximal one-legged jump with extended knee (EKJ). Ground reaction forces, cinematographic data and electromyograms of m. triceps surae were recorded. The power output, defined as the product of moment and angular velocity, and work done about the ankle were higher during CMJ (1404 W, 130 J) than during EKJ (852 W, 76 J). The peak moments were the same during both jumps. The model of the m. triceps surae showed that the power delivered by m. triceps surae was higher during CMJ than during EKJ, as a result of catapult-action of m. gastrocnemius tendon. The difference in work done is explained, in addition to transportation of energy, by a greater contraction range of m. soleus during CMJ. There is no reason to assume that pre-stretch potentiation plays a role in the difference in mechanical output. The results show that the mechanical output of muscles in complex movements is strongly dependent on the dynamics of the movement, and not only on its contractile capacity.     

A simplification of a completeness proof of Guaspari and Solovay

The modal completeness proofs of Guaspari and Solovay (1979) for their systems R and R ^– are improved and the relationship between R and R ^– is clarified.     

An evaluation of differential reinforcement of other behavior,differential reinforcement of incompatible behavior,and restitution for the management of aggressive behaviors

A 46 year old institutionalized retarded woman was referred for treatment because of frequent verbal abuse and physically aggressive behaviors. A multicomponent behavioral intervention consisting of differential reinforcement of other behaviors, differential reinforcement of incompatible behaviors, and restitution was implemented. A sequential withdrawal design was used in order to evaluate the effects of components of the original intervention, and to provide a measure of response maintenance. Results indicated a marked decrease in verbal abuse and elimination of physical aggression. Verbal abuse recurred when the restitution procedure was withdrawn. The relative efficacy of the different interventions is discussed with respect to the behavioral management of aggression. © 1998 John Wiley & Sons, Ltd.     

Young Muslim Women in France: Cultural and Psychological Adjustments

Even though France has experienced increasing and inevitable feminization in its immigrant population since 1974, research has tended to ignore the role of immigrant women, especially Muslim women, in the migration process. Public attention has been diverted by concern over such relatively marginal issues as the headscarf affair, and insufficient attention has been paid to the important role Muslim women play in France, especially those coming from Algeria. These women function as cultural mediators between the traditional culture of the sending country and the modern one of the host country. They see themselves as both tradition-bearers and integration proponents. The demands of immigration have given rise to the growth and development of different leaders, among them cultural mediators seeking a bridge between Islam and modernity, economic mediators seeking to establish women in the media and as entrepreneurs, and political mediators who seek access to power at the local level for the immigrants. These new mediators will eventually shape a new generation of female actors very far from the traditional countries of origin, although for the time being they still suffer from the inequality of rights for women and chances in their overall social life.     

Reasoning about update logic

Logical frameworks for analysing the dynamics of information processing abound [4, 5, 8, 10, 12, 14, 20, 22]. Some of these frameworks focus on the dynamics of the interpretation process, some on the dynamics of the process of drawing inferences, and some do both of these. Formalisms galore, so it is felt that some conceptual streamlining would pay off.This paper is part of a larger scale enterprise to pursue the obvious parallel between information processing and imperative programming. We demonstrate that logical tools from theoretical computer science are relevant for the logic of information flow. More specifically, we show that the perspective of Hoare logic [13, 18] can fruitfully be applied to the conceptual simplification of information flow logics.     

Correspondence analysis and association models constrained by a conditional independence graph

The manner in which the conditional independence graph of a multiway contingency table effects the fitting and interpretation of the Goodman association model (RC) and of correspondence analysis (CA) is considered.Estimation of the row and column scores is presented in this context by developing a unified framework that includes both models. Incorporation of the conditional independence constraints inherent in the graph may lead to equal or additive scores for the corresponding marginal tables, depending on the topology of the graph. An example of doubly additive scores in the analysis of a Burt subtable is given.Thanks are due to anonymous referees who substantially improved the original draft of this paper.