Aggressive behavior inhibition by serotonin and quipazine injected into the amygdala in the rat

The effects on aggressive behavior, open-field activity, and pain threshold of bilateral microinjections of serotonin (20 micrograms) and quipazine (20 micrograms), the direct serotonergic receptor agonist, into the cortico-medial amygdala were investigated in Wistar rats. Both drugs significantly prolonged the attack latency in isolated killer rats (predatory aggression model), and suppressed the incidence of aggressive postures/attacks in shock-induced fighting test (affective aggression). The only difference in the open-field behavior was the lower number of central square entries in drug-treated compared to saline-injected rats. None of the substances produced any significant change in jump threshold. It is concluded that stimulation of serotonin receptors within the amygdala produces inhibition of affective and muricidal behavior in isolated rats. The effect does not seem to be dependent on changes in general activity and pain sensitivity.     

Frequency of neurologic-psychiatric findings in the late phase following minor and medium severe blunt craniocerebral injuries

The authors present a short review of the pertinent literature and report on their own neuropsychiatric findings following internal craniocerebral injuries, at the same time drawing attention to the necessity of psychological examination. Statistical comparisons with the international literature are complicated owing to the different classifications used for craniocerebral injuries.     

The utility of differentiating between mixed and pure forms of antisocial child behavior

This study examined the utility of classifying boys on the basis of a typology of antisocial behavior. A group of 195 boys, aged 10–17, was divided into four mutually exclusive groups based on their pattern of antisocial behavior. Stealing and fighting were chosen as criteria to define the four groups: (a) boys who fought but did not steal (Exclusive Fighter Group), (b) boys who stole but did not fight (Exclusive Theft Group), (c) boys who stole and fought (Versatile Antisocial Group), and (d) boys who did neither (Remaining Group). A multimethod-multirespondent study of these boys showed that (a) the Exclusive Fighter Group tended to score high on a range of overt antisocial behaviors and were relatively little involved in delinquency; (b) the Exclusive Theft Group tended to score high on some overt antisocial behaviors and were much involved in delinquency; (c) Versatile Antisocial youths scored highest among all groups on almost all overt and covert antisocial behaviors, and in terms of delinquent acts. The Versatile boys came from families with the most disturbed child-earing practices.The authors are indebted to Gerald Patterson for his inspiration and encouragement through-out the study. They acknowledge the most helpful comments they have received during earlier drafts of this paper from Drs. John Reid, Magda Stouthamer-Loeber, and Mark Weinrott.The paper was presented at the annual meeting of the American Society of Criminology, Denver, Colorado, November 10, 1983. The study has been funded by the Center for Studies in Crime and Delinquency, National Institute of Mental Health, Grants MH 32857 and MH 37940.     

Clinical trial of contemnol tablets (lithium retard Spofa)

A report on the clinical testing of the lithium-retard medicament Contemnol (Spofa). It details the way lithium-retard treatment is objectively and subjectively superior to the earlier and still current general lithium treatment.