Making Common Sense of Vaccines: An Example of Discussing the Recombinant Attenuated Salmonella Vaccine with the Public

Researchers have iterated that the future of synthetic biology and biotechnology lies in novel consumer applications of crossing biology with engineering. However, if the new biology’s future is to be sustainable, early and serious efforts must be made towards social sustainability. Therefore, the crux of new applications of synthetic biology and biotechnology is public understanding and acceptance. The RASVaccine is a novel recombinant design not found in nature that re-engineers a common bacteria (Salmonella) to produce a strong immune response in humans. Synthesis of the RASVaccine has the potential to improve public health as an inexpensive, non-injectable product. But how can scientists move forward to create a dialogue of creating a ‘common sense’ of this new technology in order to promote social sustainability? This paper delves into public issues raised around these novel technologies and uses the RASVaccine as an example of meeting the public with a common sense of its possibilities and limitations.     

Something in the way she moves—movement trajectories reveal dynamics of self-control

This study examined the dynamic impact of self-control conflict on action execution. We reasoned that the tug-of-war between antagonistic action tendencies is not ultimately solved before movement initiation but leaks into action execution. To this end, we measured mouse trajectories to quantify the dynamic competition between initial temptations and the struggle to overcome them. Participants moved the mouse cursor from a start location to one of two targets. Each target represented a gain or a loss of points. Although participants earned points on the majority of the trials, they also had to make movements to the loss target on some trials to prevent an even higher loss. Two experiments found that movement trajectories on these loss trials deviate toward the tempting stimulus: The way we move reveals self-control conflicts that have not been resolved prior to action execution.     

Bergson's and Sartre's Account of the Self in Relation to the Transcendental Ego

The historico-political category of 'Continental philosophy' arose in the United State and includes such figures as Adorno, Arendt, Beauvoir, Cairns, Carr, Cavailles, Deleuze, Derrida, Fink, Foucault, Funke, Gadamer, Gurwitsch, Habermas, Heidegger, Held, Ihde, Jaspers, Jonas, Kersten, Kristeva, Ingarden, Landgrebe, Levinas, Lyotard, Marcel, Marcuse, Marx, Merleau- Ponty, Mohanty, Natanson, Ortega y Gasset, Pato?ka, Reinach, Ricoeur, Sartre, Scheler, Schutz, Seebohm, Sokolowski, Spet, Stein, Stroeker, and Waldenfels. What these diverse figures share is (a) an early but not necessarily continued critical involvement with Husserl's phenomenology and (b) subsequent intellectual interaction with others who also began that way. Some comments on relations with analytic philosophy are also included with this historical sketch.     

Neuropsychologic Deficits in Children with Sickle Cell Disease and Cerebral Infarction: Role of Lesion Site and Volume

Little is known about the correlation between the location and size of cerebral infarction in children and neuropsychologic deficits. We related lesion location and volume on magnetic resonance exams to neuropsychologic performance in 28 children with cerebral infarcts due to sickle cell disease. Seventeen healthy siblings served as a comparison group. Children with anterior cerebral infarcts (n = 7) showed deficits in attention and executive skills, whereas children with more widespread cerebral infarcts (n = 18) showed additional deficits in spatial skills. The volume of cerebral infarction was associated with spatial and language performance, but minimally related to performance in other cognitive domains. The location and volume of cerebral infarction are both important for defining the type and magnitude of cognitive sequelae in childhood stroke.     

Irrational Beliefs in Employees with an Adjustment,a Depressive,or an Anxiety Disorder: a Prospective Cohort Study

It remains unclear if patients with different types of common mental disorders, such as adjustment, anxiety and depressive disorders, have the same irrational ideas. The aim of this prospective cohort study (n = 190) is to investigate differences in level and type of irrational beliefs among these groups and to examine whether a change in irrational beliefs is related to symptom recovery. Irrational beliefs (IBI) and symptoms were measured at four points in time: at baseline, after 3, 6 and 12 months. Results showed that diagnostic groups differed in their level of irrational beliefs and this effect remained over time. Highest levels of irrationality were observed in the double diagnosis group, followed by the anxiety disorder group and the depression group. Participants with adjustment disorders showed the lowest levels of irrationality, comparable to a community sample. We did not find differences in the type of irrational beliefs between diagnostic groups. The level of irrationality declined over time for all diagnostic groups. No differences in decrease were observed between diagnostic groups. The magnitude and direction of change in irrational beliefs were related to the magnitude of recovery of depressive, anxiety and stress symptoms over time. These results support the application of general cognitive interventions, especially for patients with a depressive or an anxiety disorder.     

Sociomotor action control

Our actions affect the behavior of other people in predictable ways. In the present article, we describe a theoretical framework for action control in social contexts that we call sociomotor action control. This framework addresses how human agents plan and initiate movements that trigger responses from other people, and we propose that humans represent and control such actions literally in terms of the body movements they consistently evoke from observers. We review evidence for this approach and discuss commonalities and differences to related fields such as joint action, intention understanding, imitation, and interpersonal power. The sociomotor framework highlights a range of open questions pertaining to how representations of other persons’ actions are linked to one’s own motor activity, how specifically they contribute to action initiation, and how they affect the way we perceive the actions of others.     

Priming the activation of fear and disgust: evidence for semantic processing

Given that semantic processes mediate early processes in the elicitation of emotions, we expect that already activated emotion-specific information can influence the elicitation of an emotion. In Experiment 1, participants were exposed to masked International Affective Picture System (IAPS) pictures that elicited either disgust or fear. Following the presentation of the primes, other IAPS pictures were presented as targets that elicited either disgust or fear. The participants' task was to classify the target picture as either disgust or fear evoking. In Experiment 2, we substituted the IAPS primes with facial expressions of either disgust or fear. In Experiment 3, we substituted the IAPS primes with the words disgust or fear. In all three experiments, we found that prime-target combinations of the same emotion were responded to faster than prime-target combinations of different emotions. Our findings suggest that the influence of primes on the elicitation of emotion is mediated by activated schemata or appraisal processes.     

Manipulating number generation: Loud + long = large?

Humans make numerous choices every day and tend to perceive these choices as free. The present study shows how simple free choices are biased by experiencing unrelated auditory information. In two experiments, participants categorized tones according to their intensity on the dimensions volume and duration on the majority of trials. On some trials, however, they were to randomly generate a number, and we found these choices to be influenced by tone intensity. Particularly, if participants were cued toward volume, loud tones clearly biased participants to generate larger numbers. For tone duration, a similar effect only emerged if spatial information was reinforced by the motor context of the task. The findings extend previous findings relating to the ATOM framework (A Theory of Magnitude) by an explicit focus on auditory magnitude processing. As such, they also constrain ATOM by showing that the connections between different magnitude dimensions vary to a considerable degree.