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Sandström A Säll R Peterson J Salami A Larsson A Olsson T Nyberg L 《Stress (Amsterdam, Netherlands)》2012,15(5):503-513
Deficits in executive functioning and working memory associated with frontal lobe dysfunction are prominent in depression and work-related long-term sick leave (LTSL). This study used functional magnetic resonance imaging (fMRI) to investigate potential differences in brain activation patterns in these conditions. In addition, the function of the hypothalamic-pituitary-adrenal (HPA) axis was examined and compared between groups. Since there is a clear overrepresentation of women in these diagnostic groups, and to ensure a more homogenous sample population, only women were included. To examine the neural correlates of relevant cognitive processes in patients on sick leave >90 days due to work-related LTSL, recently diagnosed patients with major depression Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV criteria, untreated), and healthy controls (n?=?10, each group), a 2-back working memory task and a visual long-term memory task were administered during fMRI scanning. HPA axis functioning was investigated using a diurnal curve of saliva cortisol and a dexamethasone suppression test. Task performance was comparable among the three groups. Multivariate image analysis revealed that both memory tasks engaged a similar brain network in all three groups, including the prefrontal and parietal cortex. During the 2-back task, LTSL patients had significant frontal hypoactivation compared to controls and patients with depression. Saliva cortisol measurements showed a flattening of the diurnal rythmicity in LTSL patients compared to patients with depression and healthy contols. Taken together, these findings indicate that work stress-related LTSL and major depression are dissociable in terms of frontal activation and diurnal cortisol rhythmicity. 相似文献
23.
S Kuntz B Poeck MB Sokolowski R Strauss 《Learning & memory (Cold Spring Harbor, N.Y.)》2012,19(8):337-340
Orientation and navigation in a complex environment requires path planning and recall to exert goal-driven behavior. Walking Drosophila flies possess a visual orientation memory for attractive targets which is localized in the central complex of the adult brain. Here we show that this type of working memory requires the cGMP-dependent protein kinase encoded by the foraging gene in just one type of ellipsoid-body ring neurons. Moreover, genetic and epistatic interaction studies provide evidence that Foraging functions upstream of the Ignorant Ribosomal-S6 Kinase 2, thus revealing a novel neuronal signaling pathway necessary for this type of memory in Drosophila. 相似文献
24.
Kunde W Pfister R Janczyk M 《Journal of experimental psychology. Human perception and performance》2012,38(3):703-714
Transformations of hand movements by tools such as levers or electronic input devices can invoke performance costs compared to untransformed movements. This study investigated by means of the Psychological Refractory Period (PRP) paradigm at which stage of information processing such tool-transformation costs arise. We used an inversion transformation, that is, the movement of the operating hand was transformed into a spatially incompatible movement of a lever. As a basic tool-transformation effect, the initiation of inverted tool movements was delayed compared to noninverted movements. Experiment 1 suggested a central (or postcentral) locus of this tool-transformation effect and ruled out a (precentral) perceptual locus. Experiments 2 and 3 confirmed the central locus and ruled out a later, motor-related stage of processing. The results show that spatially incompatible tool movements delay a capacity-limited stage of information processing, often referred to as response selection. 相似文献
25.
Thomaschke R Hopkins B Miall RC 《Journal of experimental psychology. Human perception and performance》2012,38(2):336-349
Previous research has shown that actions impair the visual perception of categorically action-consistent stimuli. On the other hand, actions can also facilitate the perception of spatially action-consistent stimuli. We suggest that motorvisual impairment is due to action planning processes, while motorvisual facilitation is due to action control mechanisms. This implies that because action planning is sensitive to modulations by cue-response mapping so should motorvisual impairment, while motorvisual facilitation should be insensitive to manipulations of cue-response mapping as is action control. We tested this prediction in three dual-task experiments. The impact of performing left and right key presses on the perception of unrelated, categorically or spatially consistent, stimuli was studied. As expected, we found motorvisual impairment for categorically consistent stimuli and motorvisual facilitation for spatially consistent stimuli. In all experiments, we compared congruent with incongruent cue-key mappings. Mapping manipulations affected motorvisual impairment, but not motorvisual facilitation. The results support our suggestion that motorvisual impairment is due to action planning, and motorvisual facilitation to action control. 相似文献
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Pusch Roland Packheiser Julian Koenen Charlotte Iovine Fabrizio Gntrkn Onur 《Animal cognition》2022,25(4):793-805
Animal Cognition - Pigeons are classic model animals to study perceptual category learning. To achieve a deeper understanding of the cognitive mechanisms of categorization, a careful consideration... 相似文献
28.
Anticipations of future sensory events have the potential of priming motor actions that would typically cause these events. Such effect anticipations are generally assumed to rely on previous physical experiences of the contingency of own actions and their ensuing effects. Here we propose that merely imagined action effects may influence behaviour similarly as physically experienced action effects do. Three experiments in the response–effect compatibility paradigm show that the mere knowledge of action–effect contingencies is indeed sufficient to incorporate these effects into action control even if the effects are never experienced as causally linked to own actions. The experiments further highlight constraints for this mechanism which seems to be rather effortful and to depend on explicit intentions. 相似文献
29.
Diagnostic work is the reflexive work of figuring out what issues are at stake and determining the scope for action. This work is not generally accommodated by evidence-based guidelines, which generally promote a uniform, predefined approach to solving healthcare problems that risk narrowing the opportunities for diagnostic work in healthcare practice. Consequently, guidelines are often criticised as too general to solve situated, individual healthcare problems and gaps between guidelines and their implementation are often reported. The Netherlands has developed a guideline for problem behaviour in elderly care, explicitly designed for diagnostic work, thus stimulating a situated approach. Relational problem behaviour is highly embedded in its context. The guideline stimulates diagnostic work, which helps to unravel problem behaviour and is opening alternatives in elderly care. Diagnostic work does not transfer guideline development problems to healthcare practice, but simply structures the decision-making process without giving a predefined answer. Diagnostic work is thus important to consider in order to avoid a gap between guideline development and implementation. 相似文献
30.
Roland Freese 《Forensische Psychiatrie, Psychologie, Kriminologie》2014,8(2):137-144
In 2007 forensic aftercare was integrated into the German Penal Code as part of legal supervision. Since then a large and growing number of patients have been supervised by forensic psychiatric aftercare units throughout Germany. Due to the federal system in Germany the system of forensic aftercare has developed differently in the 16 federal states. The number of patients looked after varies widely and the implementation of several legal norms also differs from state to state. This article gives an overview of the situation of forensic aftercare in the different German federal states and presents some specific characteristics of the development. 相似文献