Are Words Easier to Learn From Infant‐ Than Adult‐Directed Speech? A Quantitative Corpus‐Based Investigation

We investigate whether infant‐directed speech (IDS) could facilitate word form learning when compared to adult‐directed speech (ADS). To study this, we examine the distribution of word forms at two levels, acoustic and phonological, using a large database of spontaneous speech in Japanese. At the acoustic level we show that, as has been documented before for phonemes, the realizations of words are more variable and less discriminable in IDS than in ADS. At the phonological level, we find an effect in the opposite direction: The IDS lexicon contains more distinctive words (such as onomatopoeias) than the ADS counterpart. Combining the acoustic and phonological metrics together in a global discriminability score reveals that the bigger separation of lexical categories in the phonological space does not compensate for the opposite effect observed at the acoustic level. As a result, IDS word forms are still globally less discriminable than ADS word forms, even though the effect is numerically small. We discuss the implication of these findings for the view that the functional role of IDS is to improve language learnability.     

Brain activation patterns in major depressive disorder and work stress-related long-term sick leave among Swedish females

Deficits in executive functioning and working memory associated with frontal lobe dysfunction are prominent in depression and work-related long-term sick leave (LTSL). This study used functional magnetic resonance imaging (fMRI) to investigate potential differences in brain activation patterns in these conditions. In addition, the function of the hypothalamic-pituitary-adrenal (HPA) axis was examined and compared between groups. Since there is a clear overrepresentation of women in these diagnostic groups, and to ensure a more homogenous sample population, only women were included. To examine the neural correlates of relevant cognitive processes in patients on sick leave >90 days due to work-related LTSL, recently diagnosed patients with major depression Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV criteria, untreated), and healthy controls (n?=?10, each group), a 2-back working memory task and a visual long-term memory task were administered during fMRI scanning. HPA axis functioning was investigated using a diurnal curve of saliva cortisol and a dexamethasone suppression test. Task performance was comparable among the three groups. Multivariate image analysis revealed that both memory tasks engaged a similar brain network in all three groups, including the prefrontal and parietal cortex. During the 2-back task, LTSL patients had significant frontal hypoactivation compared to controls and patients with depression. Saliva cortisol measurements showed a flattening of the diurnal rythmicity in LTSL patients compared to patients with depression and healthy contols. Taken together, these findings indicate that work stress-related LTSL and major depression are dissociable in terms of frontal activation and diurnal cortisol rhythmicity.     

The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex

Orientation and navigation in a complex environment requires path planning and recall to exert goal-driven behavior. Walking Drosophila flies possess a visual orientation memory for attractive targets which is localized in the central complex of the adult brain. Here we show that this type of working memory requires the cGMP-dependent protein kinase encoded by the foraging gene in just one type of ellipsoid-body ring neurons. Moreover, genetic and epistatic interaction studies provide evidence that Foraging functions upstream of the Ignorant Ribosomal-S6 Kinase 2, thus revealing a novel neuronal signaling pathway necessary for this type of memory in Drosophila.     

The locus of tool-transformation costs

Transformations of hand movements by tools such as levers or electronic input devices can invoke performance costs compared to untransformed movements. This study investigated by means of the Psychological Refractory Period (PRP) paradigm at which stage of information processing such tool-transformation costs arise. We used an inversion transformation, that is, the movement of the operating hand was transformed into a spatially incompatible movement of a lever. As a basic tool-transformation effect, the initiation of inverted tool movements was delayed compared to noninverted movements. Experiment 1 suggested a central (or postcentral) locus of this tool-transformation effect and ruled out a (precentral) perceptual locus. Experiments 2 and 3 confirmed the central locus and ruled out a later, motor-related stage of processing. The results show that spatially incompatible tool movements delay a capacity-limited stage of information processing, often referred to as response selection.     

The role of cue-response mapping in motorvisual impairment and facilitation: evidence for different roles of action planning and action control in motorvisual dual-task priming

Previous research has shown that actions impair the visual perception of categorically action-consistent stimuli. On the other hand, actions can also facilitate the perception of spatially action-consistent stimuli. We suggest that motorvisual impairment is due to action planning processes, while motorvisual facilitation is due to action control mechanisms. This implies that because action planning is sensitive to modulations by cue-response mapping so should motorvisual impairment, while motorvisual facilitation should be insensitive to manipulations of cue-response mapping as is action control. We tested this prediction in three dual-task experiments. The impact of performing left and right key presses on the perception of unrelated, categorically or spatially consistent, stimuli was studied. As expected, we found motorvisual impairment for categorically consistent stimuli and motorvisual facilitation for spatially consistent stimuli. In all experiments, we compared congruent with incongruent cue-key mappings. Mapping manipulations affected motorvisual impairment, but not motorvisual facilitation. The results support our suggestion that motorvisual impairment is due to action planning, and motorvisual facilitation to action control.     

Traditional Roles in a Non-Traditional Setting: Genetic Counseling in Precision Oncology

Next generation sequencing technology is increasingly utilized in oncology with the goal of targeting therapeutics to improve response and reduce side effects. Interpretation of tumor mutations requires sequencing of paired germline DNA, raising questions about incidental germline findings. We describe our experiences as part of a research team implementing a protocol for whole genome sequencing (WGS) of tumors and paired germline DNA known as the Michigan Oncology Sequencing project (MI-ONCOSEQ) that includes options for receiving incidental germline findings. Genetic counselors (GCs) discuss options for return of results with patients during the informed consent process and document family histories. GCs also review germline findings and actively participate in the multi-disciplinary Precision Medicine Tumor Board (PMTB), providing clinical context for interpretation of germline results and making recommendations about disclosure of germline findings. GCs have encountered ethical and counseling challenges with participants, described here. Although GCs have not been traditionally involved in molecular testing of tumors, our experiences with MI-ONCOSEQ demonstrate that GCs have important applicable skills to contribute to multi-disciplinary care teams implementing precision oncology. Broader use of WGS in oncology treatment decision making and American College of Medical Genetics and Genomics (ACMG) recommendations for active interrogation of germline tissue in tumor-normal dyads suggests that GCs will have future opportunities in this area outside of research settings.     

Digital embryos: a novel technical approach to investigate perceptual categorization in pigeons (Columba livia) using machine learning

Animal Cognition - Pigeons are classic model animals to study perceptual category learning. To achieve a deeper understanding of the cognitive mechanisms of categorization, a careful consideration...     

Perceiving by proxy: Effect-based action control with unperceivable effects

Anticipations of future sensory events have the potential of priming motor actions that would typically cause these events. Such effect anticipations are generally assumed to rely on previous physical experiences of the contingency of own actions and their ensuing effects. Here we propose that merely imagined action effects may influence behaviour similarly as physically experienced action effects do. Three experiments in the response–effect compatibility paradigm show that the mere knowledge of action–effect contingencies is indeed sufficient to incorporate these effects into action control even if the effects are never experienced as causally linked to own actions. The experiments further highlight constraints for this mechanism which seems to be rather effortful and to depend on explicit intentions.     

Diagnostic Work through Evidence-Based Guidelines: Avoiding Gaps Between Development and Implementation of a Guideline for Problem Behaviour in Elderly Care

Diagnostic work is the reflexive work of figuring out what issues are at stake and determining the scope for action. This work is not generally accommodated by evidence-based guidelines, which generally promote a uniform, predefined approach to solving healthcare problems that risk narrowing the opportunities for diagnostic work in healthcare practice. Consequently, guidelines are often criticised as too general to solve situated, individual healthcare problems and gaps between guidelines and their implementation are often reported. The Netherlands has developed a guideline for problem behaviour in elderly care, explicitly designed for diagnostic work, thus stimulating a situated approach. Relational problem behaviour is highly embedded in its context. The guideline stimulates diagnostic work, which helps to unravel problem behaviour and is opening alternatives in elderly care. Diagnostic work does not transfer guideline development problems to healthcare practice, but simply structures the decision-making process without giving a predefined answer. Diagnostic work is thus important to consider in order to avoid a gap between guideline development and implementation.     

Zum Stand der forensischen und forensisch-psychiatrischen Nachsorge in der Bundesrepublik Deutschland (Daten aus der sog. Pfingstabfrage 2013)

In 2007 forensic aftercare was integrated into the German Penal Code as part of legal supervision. Since then a large and growing number of patients have been supervised by forensic psychiatric aftercare units throughout Germany. Due to the federal system in Germany the system of forensic aftercare has developed differently in the 16 federal states. The number of patients looked after varies widely and the implementation of several legal norms also differs from state to state. This article gives an overview of the situation of forensic aftercare in the different German federal states and presents some specific characteristics of the development.