Absence of an interaction between navigational strategies based on local and distal landmarks

In 3 experiments, rats were required to escape from a Morris pool by swimming to a submerged platform that was located at the apex of a notional, equilateral triangle with 2 different landmarks occupying the corners at the base. Training for 1 group was always conducted in view of the landmarks surrounding the pool and with the triangular array in a fixed orientation. Subjects could therefore identify the direction of the platform from a single landmark within the pool by reference to cues outside the pool or to the other landmark within the pool. Both strategies were used, and the results from additional groups revealed that the first of these strategies did not affect the acquisition of the second one.     

Transfer of spatial behavior between different environments: implications for theories of spatial learning and for the role of the hippocampus in spatial learning

In 3 experiments, rats were required to find a submerged platform located in 1 corner of an arena that had 2 long and 2 short sides; they were then trained to find the platform in a new arena that also had 2 long and 2 short sides but a different overall shape. The platform in the new arena was easier to find if it was in a corner that was geometrically equivalent, rather than the mirror image, of the corner where it had previously been located. The final experiment revealed that hippocampal lesions impaired rats' ability to find the platform in these arenas. The results suggest that rats did not use the overall shape of the arena to locate the platform but relied on more local cues and that the hippocampus plays a role in navigation based on these cues.     

A paradoxical dissociation in the effects of midazolam on recollection and automatic processes in the process dissociation procedure

This study used midazolam-induced amnesia to explore the plausibility of the estimates provided by the process dissociation procedure (PDP), which is designed to estimate the contributions of recollection (R) and automatic (A) processes to implicit memory performance. In a double-blind, placebo-controlled, within-subject design with 24 participants, single midazolam doses were administered intravenously, and word stem completion performance was used to calculate PDP estimates. A dissociation was observed such that midazolam decreased R but increased A estimates relative to placebo. Given that a manipulation that induces amnesia would not be expected to facilitate a memory process, these results add to the accumulating body of evidence suggesting that PDP estimates are not always theoretically plausible. Such evidence raises important questions about the use of the PDP.     

Multisensory temporal order judgments: when two locations are better than one

In Experiment 1, participants were presented with pairs of stimuli (one visual and the other tactile) from the left and/or right of fixation at varying stimulus onset asynchronies and were required to make unspeeded temporal order judgments (TOJs) regarding which modality was presented first. When the participants adopted an uncrossed-hands posture, just noticeable differences (JNDs) were lower (i.e., multisensory TOJs were more precise) when stimuli were presented from different positions, rather than from the same position. This spatial redundancy benefit was reduced when the participants adopted a crossed-hands posture, suggesting a failure to remap visuotactile space appropriately. In Experiment 2, JNDs were also lower when pairs of auditory and visual stimuli were presented from different positions, rather than from the same position. Taken together, these results demonstrate that people can use redundant spatial cues to facilitate their performance on multisensory TOJ tasks and suggest that previous studies may have systematically overestimated the precision with which people can make such judgments. These results highlight the intimate link between spatial and temporal factors in determining our perception of the multimodal objects and events in the world around us.     

Influence of instruction on velocity and accuracy of overarm throwing

This study investigated the influence of instruction on the ball velocity and accuracy of a goal-directed overarm throw. 9 experienced Norwegian male team handball players executed a throwing task randomly seven times under 5 different instructions varying from emphasizing speed to accuracy. When instructions increasingly emphasized accuracy, velocity decreased. However, accuracy did not improve when subjects were instructed to focus on it. A possible explanation for this finding could lie in the specific subject group. The subjects were highly experienced team handball players with an average of 12 years in the sport. Thus, the accuracy they demonstrated at high velocity might actually be already extremely high and difficult to improve upon when reducing throwing velocity. Further, the velocity of throwing when instruction emphasized accuracy was approximately 85% of the maximal velocity, indicating that experienced team handball players are trained to throw accurately at relatively high velocity.     

Are Words Easier to Learn From Infant‐ Than Adult‐Directed Speech? A Quantitative Corpus‐Based Investigation

We investigate whether infant‐directed speech (IDS) could facilitate word form learning when compared to adult‐directed speech (ADS). To study this, we examine the distribution of word forms at two levels, acoustic and phonological, using a large database of spontaneous speech in Japanese. At the acoustic level we show that, as has been documented before for phonemes, the realizations of words are more variable and less discriminable in IDS than in ADS. At the phonological level, we find an effect in the opposite direction: The IDS lexicon contains more distinctive words (such as onomatopoeias) than the ADS counterpart. Combining the acoustic and phonological metrics together in a global discriminability score reveals that the bigger separation of lexical categories in the phonological space does not compensate for the opposite effect observed at the acoustic level. As a result, IDS word forms are still globally less discriminable than ADS word forms, even though the effect is numerically small. We discuss the implication of these findings for the view that the functional role of IDS is to improve language learnability.     

Brain activation patterns in major depressive disorder and work stress-related long-term sick leave among Swedish females

Deficits in executive functioning and working memory associated with frontal lobe dysfunction are prominent in depression and work-related long-term sick leave (LTSL). This study used functional magnetic resonance imaging (fMRI) to investigate potential differences in brain activation patterns in these conditions. In addition, the function of the hypothalamic-pituitary-adrenal (HPA) axis was examined and compared between groups. Since there is a clear overrepresentation of women in these diagnostic groups, and to ensure a more homogenous sample population, only women were included. To examine the neural correlates of relevant cognitive processes in patients on sick leave >90 days due to work-related LTSL, recently diagnosed patients with major depression Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV criteria, untreated), and healthy controls (n?=?10, each group), a 2-back working memory task and a visual long-term memory task were administered during fMRI scanning. HPA axis functioning was investigated using a diurnal curve of saliva cortisol and a dexamethasone suppression test. Task performance was comparable among the three groups. Multivariate image analysis revealed that both memory tasks engaged a similar brain network in all three groups, including the prefrontal and parietal cortex. During the 2-back task, LTSL patients had significant frontal hypoactivation compared to controls and patients with depression. Saliva cortisol measurements showed a flattening of the diurnal rythmicity in LTSL patients compared to patients with depression and healthy contols. Taken together, these findings indicate that work stress-related LTSL and major depression are dissociable in terms of frontal activation and diurnal cortisol rhythmicity.     

The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex

Orientation and navigation in a complex environment requires path planning and recall to exert goal-driven behavior. Walking Drosophila flies possess a visual orientation memory for attractive targets which is localized in the central complex of the adult brain. Here we show that this type of working memory requires the cGMP-dependent protein kinase encoded by the foraging gene in just one type of ellipsoid-body ring neurons. Moreover, genetic and epistatic interaction studies provide evidence that Foraging functions upstream of the Ignorant Ribosomal-S6 Kinase 2, thus revealing a novel neuronal signaling pathway necessary for this type of memory in Drosophila.     

The locus of tool-transformation costs

Transformations of hand movements by tools such as levers or electronic input devices can invoke performance costs compared to untransformed movements. This study investigated by means of the Psychological Refractory Period (PRP) paradigm at which stage of information processing such tool-transformation costs arise. We used an inversion transformation, that is, the movement of the operating hand was transformed into a spatially incompatible movement of a lever. As a basic tool-transformation effect, the initiation of inverted tool movements was delayed compared to noninverted movements. Experiment 1 suggested a central (or postcentral) locus of this tool-transformation effect and ruled out a (precentral) perceptual locus. Experiments 2 and 3 confirmed the central locus and ruled out a later, motor-related stage of processing. The results show that spatially incompatible tool movements delay a capacity-limited stage of information processing, often referred to as response selection.