Self-criticism,interpersonal conditions,and biosystemic inflammation in suicidal thoughts and behaviors within mood disorders: A bio-cognitive-interpersonal hypothesis

We review the theoretical and empirical literature on the role of self-concept in suicidal behavior in the context of mood disorders (i.e., unipolar depression and bipolar spectrum disorders). The main themes emanating from this review are then juxtaposed against (a) the Interpersonal-Psychological Theory of Suicide and (b) biological research on the role of inflammatory processes in suicidality. Such a juxtaposition paves the way for a bio-cognitive-interpersonal hypothesis. Pathologies of the self-concept—primarily self-criticism—propel mood disorder sufferers to generate interpersonal stress that culminates in two proximal causes of suicidality: thwarted belongingness and perceived burdensomeness. In turn, these two interpersonal conditions set in motion systemic biosystemic inflammation, serving as a proximal cause for suicidality in mood disorders. We conclude by describing a research project aimed at testing this hypothesis, and by outlining pertinent implications for assessment, treatment, and prevention.     

Sean J. McGrath: Thinking nature: an essay in negative ecology

Continental Philosophy Review - Thinking Nature is essay in negative ecology, written in part to commemorate the deaths nature has died, pace Morton, ?i?ek, and even Latour. We have...     

The violent adolescent: the urge to destroy versus the urge to feel alive

The dynamics of adolescent violence are explored from theoretical and developmental perspectives applied to the review of psychoanalytic studies of violence and three cases: the case of Willie Bosket, presented in Fox Butterfield's All God's Children, an adolescent treated by one of the authors, and observation of staff dynamics in a juvenile detention facility. Studies indicate that violence is used to preserve a sense of existence and psychic equilibrium as well as to express rage and destroy unwanted projected parts of the self and dangerous intrusions into a fragile self-coherence. In the case studies, violent activity serves a number of psychic functions: it leads to high arousal states and the feeling of being alive thereby disavowing underlying feelings of deadness and depression, it serves to contain and discharge overwhelming chaotic and rageful feelings, and it enacts object ties and the unconscious fantasies of the parent. Staff dynamics in a treatment setting for juvenile offenders reflect the intrapsychic dynamics of the juvenile offender prone to acting out, projection, hypervigilance to signs of disrespect, and disavowal of unwanted affects including helplessness and vulnerability.     

Screening for adolescent psychopathy among at-risk youth: initial validation of the Survey of Attitudes and Life Experiences

Psychopathic youth pose special challenges to clinicians in providing effective treatment and safe management. Because comprehensive assessments of psychopathy are time intensive and require specialized training, programmatic research is needed to develop time-efficient and useful screens that eliminate from further consideration acting-out adolescents who are unlikely to be psychopathic. The clinical utility of the Survey of Attitudes and Life Erperiences as a psychopathy screen was investigated by combining three samples of adolescent offenders (total N = 223). Its primary purpose was the identification of nonpsychopaths who were distinguished from adolescents in either the mixed or psychopathic ranges. A Psychopathy Screen (PS) Scale was developed with 24-item (PS-24) and 11-item (PS-11) versions. Both appeared moderately effective in excluding nonpsychopaths from further evaluation. Preliminary data on response styles suggest that these scales are not susceptible to social desirability.     

Axis I screens and suicide risk in jails: a comparative analysis

Mental health professionals conducting screenings in jail settings face formidable challenges in identifying inmates at risk for major depression and suicide. Psychologists often rely on correctional staff to provide initial appraisals of those inmates requiring further evaluation. In a sample of 100 jail detainees, the effectiveness of two specialized screens (the Referral Decision Scale and Mental Disability/Suicide Intake Screen or MDSIS) and one general screen (Personality Assessment Screener or PAS) was evaluated. For suicidal ideation, the MDSIS composite score evidenced promise (sensitivity = 1.00; specificity = 0.71). In ruling out major depression, the PAS Negative Affect subscale was useful for the inmate participants.     

Selective inactivation of the ventral hippocampus attenuates cue-induced and cocaine-primed reinstatement of drug-seeking in rats

Recent evidence suggests that the hippocampus may have a functional role in mediating relapse to cocaine-seeking behavior. Based on the importance of the ventral CA subfields in mediating reward, the present experiment determined the effects of temporary inactivation of the ventral hippocampus on reinstatement of cocaine-seeking in a rodent model of relapse. Male, Sprague-Dawley rats self-administered i.v. cocaine (0.6 mg/kg/infusion) in the presence of discrete conditioned cues (tone+light) in daily 2-h sessions for ten days. Following seven days of extinction sessions in which neither cues nor drug were available, rats underwent four reinstatement tests in a counterbalanced, within-subjects design. Bilateral microinjections of GABA receptor agonists (baclofen/muscimol (B/M; 1.0 mM/0.1 mM) [corrected] into the ventral hippocampus significantly attenuated cue-induced and cocaine-primed reinstatement compared with vehicle microinjections in the same rats. In contrast, injections just outside the ventral hippocampus did not block either form of reinstatement. Furthermore, inactivation failed to affect responding for food reinforcement, baseline extinction responding, or locomotor activity. These data indicate that the ventral hippocampus plays an important role in the relapse to cocaine-seeking behavior and may interact with key limbic structures previously implicated in cocaine addiction.     

Recognition of temporal patterns: from engineering to psychology and back again.

An overview is presented on research conducted in our lab to quantify the underlying principles behind the recognition of temporal patterns. We have been developing a theory based upon pattern matching and time-series analysis, which allows us to model and understand how humans recognize familiar patterns evolving over time and how performance degrades with noise. While our studies are primarily scientific in nature, the work has application beyond the elucidation of psychological and physiological mechanisms. We illustrate an application of these ideas to computer-based human identification through gait analysis. This study also illustrates a novel approach to interdisciplinary research by integrating experimental psychology with that of engineering design.     

Intrapersonal and Interpersonal Factors Influencing Adolescents' Decisions About Having Sex: A Test of Sufficiency of the Theory of Planned Behavior1

This study tested the theory of planned behavior's (TPB) expectation that attitudes, social norms, and self‐efficacy would mediate other variables' effects on intention for having sex and probability of having sex. Longitudinal data were collected from 790 high‐school‐aged adolescents. In an intrapersonal variable model, sensation seeking, alcohol use, hard work, smoking, and moral beliefs had mediated effects, but the last 2 also had direct effects (on intention and behavior, respectively). In an interpersonal model, school attachment had mediated effects, pressure to have sex had a direct effect on behavior, and parent communication and number of sexually active friends had both. Intrapersonal variable effects were better described by the TPB than those of interpersonal variables. Targeting distal psychosocial factors may enhance intervention efficacy.