Immobilization Stress Elevates GTP Cyclohydrolase I mRNA Levels in Rat Adrenals Predominantly by Hormonally Mediated Mechanisms

GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis. In this study we examined the effect of immobilization stress on GTPCH mRNA levels and the mechanism(s) of stress-induced changes in adrenomedullary GTPCH mRNA levels. We used reverse-polymerase chain reaction to isolate and clone a cDNA corresponding to nucleotides 269 to 570 of rat GTPCH. Northern blot analysis with a cRNA probe revealed two species of GTPCH mRNA (about 3.6 and 1.2 kb) in rat adrenal medulla and cortex, and in PC12 cells. The levels of both forms of GTPCH mRNA were significantly increased 3-5 fold in adrenal medulla by a single 2 hour immobilization and by repeated immobilizations (2 hours a day for 2 days). Hypophysectomy had little effect on their basal levels but prevented the stress elicited rise in both GTPCH mRNAs. In contrast, unilateral transection of the splanchnic nerve did not affect induction of the 3.6 kb GTPCH mRNA by stress. Combined denervation with hypophysectomy completely blocked the induction of both GTPCH mRNA species by immobilization stress. Thus, stress elicits elevation of both forms of GTPCH mRNA by a mechanism requiring an intact pituitary-adrenocortical axis.     

Bidirectional Spillover in the Family across the Transition to Parenthood

Although family systems theory posits reciprocal causality between subsystems of the family, such as intimate partner violence exacerbating harsh parenting and vice versa, longitudinal studies with cross‐lagged models have been used infrequently to test these principles. As guided by the spillover model, this study examined bidirectional associations between couple dysfunction, parent–child aggression risk, and child functioning across the transition to parenthood to determine whether and how disruptions in one subsystem relate to problems in other family subsystems. Participants were 201 first‐time mothers and 151 fathers from a diverse community sample, evaluated during pregnancy, and reassessed two more times through their child's first 18 months of life. Individual and dyadic path model results indicate bidirectional spillover effects between parent–child aggression risk and child functioning for both mothers and fathers, and spillover from parent–child aggression risk to couple dysfunction for mothers but not fathers. However, limited spillover effects were identified between couple functioning and child adjustment, in contrast to previous work. Findings suggest that spillover can happen reciprocally and early in the family, supporting transactional models of behavior and highlighting the need for early family level intervention.     

Attenuated brain responses to speech sounds in moderate preterm infants at term age

Recent findings have revealed that very preterm neonates already show the typical brain responses to place of articulation changes in stop consonants, but data on their sensitivity to other types of phonetic changes remain scarce. Here, we examined the impact of 7–8 weeks of extra‐uterine life on the automatic processing of syllables in 20 healthy moderate preterm infants (mean gestational age at birth 33 weeks) matched in maturational age with 20 full‐term neonates, thus differing in their previous auditory experience. This design allows elucidating the contribution of extra‐uterine auditory experience in the immature brain on the encoding of linguistically relevant speech features. Specifically, we collected brain responses to natural CV syllables differing in three dimensions using a multi‐feature mismatch paradigm, with the syllable/ba/ as the standard and three deviants: a pitch change, a vowel change to/bo/ and a consonant voice‐onset time (VOT) change to/pa/. No significant between‐group differences were found for pitch and consonant VOT deviants. However, moderate preterm infants showed attenuated responses to vowel deviants compared to full terms. These results suggest that moderate preterm infants' limited experience with low‐pass filtered speech prenatally can hinder vowel change detection and that exposure to natural speech after birth does not seem to contribute to improve this capacity. These data are in line with recent evidence suggesting a sequential development of a hierarchical functional architecture of speech processing that is highly sensitive to early auditory experience.     

Parent–Child Aggression Risk in Expectant Mothers and Fathers: A Multimethod Theoretical Approach

The current investigation evaluated whether cognitive processes characteristic of the Social Information Processing model predicted parent–child aggression (PCA) risk independent of personal vulnerabilities and resiliencies. This study utilized a multimethod approach, including analog tasks, with a diverse sample of 203 primiparous expectant mothers and 151 of their partners. Factors considered in this study included PCA approval attitudes, empathy, reactivity, negative child attributions, compliance expectations, and knowledge of non-physical discipline alternatives; additionally, vulnerabilities included psychopathology symptoms, domestic violence victimization, and substance use, whereas resiliencies included perceived social support, partner relationship satisfaction, and coping efficacy. For both mothers and fathers, findings supported the role of greater approval of PCA attitudes, lower empathy, more overreactivity, more negative attributions, and higher compliance expectations in relation to elevated risk of PCA. Moreover, personal vulnerabilities and resiliencies related to PCA risk for mothers; however, fathers and mothers differed on the nature of these relationships with respect to vulnerabilities as well as aspects of empathy and PCA approval attitudes. Findings provide evidence for commonalities in many of the factors investigated between mothers and fathers with some notable distinctions. Results are discussed in terms of how findings could inform prevention programs.     

Intimate partner violence among HIV positive pregnant women in South Africa

The aim of the study was to determine the prevalence of intimate partner violence (IPV) and associated factors among pregnant HIV-infected women in primary health care facilities in Nkangala and Gert Sibande districts, Mpumalanga, South Africa. Participants were 673 women who were, on average, 28.39 ± 5.73 years old. Data were collected through Audio Computer Assisted Self Interview (ACASI), and analysed using the IBM Statistical Package for Social Sciences (SPSS). Overall, 56.3% reported having experienced either psychological or physical IPV, and 19.6% reported physical IPV. In logistic multivariable regression analyses, higher levels of depressive symptoms and greater perceived stigma were associated with combined physical and psychological IPV. Psychological IPV and physical IPV were also individually associated with greater perceived stigma and higher levels of depressive symptoms. The design and implementation of evidence-informed interventions that can empower and protect HIV-infected pregnant women from IPV is essential to managing their health-related quality of life.     

Counseling Latino University Students: Psychosociocultural Issues for Consideration

Salient issues for Latino students on predominately White university campuses are identified and discussed. In particular, university counseling center (UCC) service providers can help diminish or diffuse educational and social difficulties of Latino students by considering psychosociocultural issues in counseling, such as university cultural environment, ethnic identity, acculturation, and social support from family and mentors. These concepts are illustrated and discussed through vignettes. Specific strategies for UCC service providers are also presented. Finally, attitudes and beliefs, knowledge, and skills necessary to provide competent psychosociocultural services to Latino students are identified.     

Gay and Lesbian Christians: Homosexual and Religious Identity Integration in the Members and Participants of a Gay-Positive Church

In this study we explore individual 's experiences of identity integration between their sexual orientation and religious beliefs. Using both qualitative and quantitative research methods, we examined identity integration in forty members and participants of the Metropolitan Community Church of New York (MCC/NY), a gay-positive church located in Mid-town Manhattan. The survey and interview data collected showed that: (1)a majority of the research participants reported that they had successfully integrated their homosexual and religious identities, (2) being integrated was related to higher role involvement at MCC/NY, being a member of the church, attending more MCC/NY worship services and activities/ministries, and attending MCC/NY for more years, (3) lesbians were less likely than gay men to report past conflict between their identities, and more likely to report being fully integrated, and (4) MCC/NY played an important role in helping these participants achieve integration between their homosexual and religious identities.     

Psychological essentialism and the differential attribution of uniquely human emotions to ingroups and outgroups

According to the psychological essentialism perspective, people tend to explain differences between groups by attributing them different essences. Given a pervasive ethnocentrism, this tendency implies that the human essence will be restricted to the ingroup whereas outgroups will receive a lesser degree of humanity. Therefore, it is argued that people attribute more uniquely human characteristics to the ingroup than to the outgroup. The present article focuses on secondary emotions that constitute such characteristics. Study 1 showed that members of high‐ and low‐status groups attribute more positive secondary emotions to the ingroup than to the outgroup. Study 2 verified that the differential attribution extended also to negative secondary emotions. No exemplars of emotions were provided in Study 3. Instead, participants had to estimate the means of two distributions of numbers that supposedly represented characteristics of the ingroup and of the outgroup. The results of this third experiment illustrated the reluctance to attribute secondary emotions to the outgroup. The findings are discussed from the perspective of psychological essentialism. Copyright © 2001 John Wiley & Sons, Ltd.