An animal model of the hyperactive-child syndrome suitable for the study of the effects of food additives

This report describes the use of an animal model for testing the relationship between the effects of ingesting food additives and hyperactivity. Telomian × beagle hybrid dogs were chosen as subjects because this breed has been observed to exhibit behavior seen as analogous to the hyperactivity of children. Two studies were conducted by adding or deleting butylated hydroxyanisole and Food, Drug, and Cosmetic red dye number 40 to the diet of each dog. A test of sitting was performed to measure the level of activity. While a relationship was not observed between the ingestion of the additive and the level of activity, several issues pertaining to the use of the animal model became apparent. These issues and the use of animals for future research in this area are discussed.     

Hand differences in the rate and variability of rapid tapping

Hand differences in the rate and variability of rapid tapping were evaluated for the intertap interval and its constituents-the key depression and key release phases of each tap. To accentuate potential hand differences, only subjects with a clear manual superiority in one hand were included. Relative manual proficiency on Fitts' reciprocal tapping task was used to exclude individuals with less-defined hand superiority or dominance, and to categorize subjects as having a dominant left (n=13) or right (n=11) hand. Analysis of variance indicated the dominant hand to have a shorter average intertap interval and thus a faster tapping rate. This hand difference in rate was found to be significant for the key-depression phase, but not the key-release.phase, of the tap. In each handedness group the dominant hand exhibited less variability in the intertap interval and both constituents. Potential associations of these findings with hemispheric asymmetries in sequential ability are discussed.     

Incidental learning,attention, and curiosity in squirrel monkeys calorie deprived as infants

The long-term effects of infantile malnutrition on information processing were studied in squirrel monkeys. From 2 through 8 weeks of age, four low-calorie infants were fed reduced amounts of a high protein diet, limiting their mean body weight gain to 23% of that of four well-fed controls, with all of this gain occurring during the first 2 weeks on the low-calorie diet. Thereafter, both groups received the standard diet ad libitum. At 68 weeks of age, incidental learning was tested by introducing shape cues that were redundant to the solution of a previously learned, two-choice, color discrimination. Removal of the color cues showed that the low-calorie monkeys had learned significantly less about the shape cues than had the controls. The basis for this incidental learning failure was then examined with an embedded-figures dicrimination, to measure attentional ability, and a novel stimulus substitution task, to measure curiosity. The groups did not differ in detecting embedded figures, but the low-calorie monkeys were significantly less likely than controls to select or handle novel stimuli that had been substituted for previously learned discriminative cues. It was concluded that undernutrition in infancy may induce a long-term strategy of only learning information which leads to an immediate reward, while suppressing the acquisition of information due to intrinsic curiosity.     

An information processing system for the psychiatric emergency room

An information processing system for a psychiatric emergency room is described. Several studies are presented that show the utility of the system. In the first study, variables involved in diagnosis are explicated. The second study attempts to determine the characteristics that distinguish recidivists from nonrecidivists at an emergency room. The third study attempts to find patient variables related to success in short-term treatment programs. The final study is aimed at discovering whether there are psychopathological effects related to the use of inhalants. Together, these studies show the potential of a mental health information system for learning more about the nature of mental disorders and their treatment.     

Alternative solutions to kinetic stimulus transformations

It has been assumed that certain stimulus transformations lead directly to depth effects, that is, that such transformations are the necessary and sufficient conditions for kinetically generated depth perception. An alternative is to view such perception as the preferred solution to the problem posed by the transforming stimulus as to what even in the world is producing that transformation. In several experiments it is shown that when other solutions are supportable by the stimulus, those same transformations will no longer lead to depth perception. These other solutions become preferred on the basis of rejection of certain coincidental features of the stimulus that otherwise would have to be accepted were the kinetic depth solution to be maintained. The findings are interpreted as challenging any theory that perception is simply the direct result of stimulation or of extraction of stimulus information and as supporting the Helmkoltzian rule of perception as a construction of the most reasonable representation.     

Does nutrition cause intelligence? A reanalysis of the Cali experiment

Recent literature has suggested there is a causal link between malnutrition and impaired cognitive development. From a selective review of this literature it is concluded that owing to methodological imperfections in many of these studies the presence or absence of such a link cannot be established, even if randomized experiments were to be carried out. It is argued that compensatory experiments, even though they are not as logically compelling as experiments where proper nutrition is withheld, are ethically justifiable and more useful strategically since they may suggest ways of improving the cognitive development of currently affected children, especially if a variety of compensatory treatments is implemented. A reanalysis of such an experiment was conducted to determine whether the nutritional or educational component of the treatment was responsible for the observed gains in cognitive development. The reanalysis indicated that after four years of treatment there was no association between cognitive and nutritional status. The results were discussed in relation to previous research. Some of the social implications of the results were also discussed.     

How to maximize reward rate on two variable-interval paradigms

Without assuming any constraints on behavior, we derive the policy that maximizes overall reward rate on two variable-interval paradigms. The first paradigm is concurrent variable time-variable time with changeover delay. It is shown that for nearly all parameter values, a switch to the schedule with the longer interval should be followed immediately by a switch back to the schedule with the shorter interval. The matching law does not hold at the optimum and does not uniquely specify the obtained reward rate. The second paradigm is discrete trial concurrent variable interval-variable interval. For given schedule parameters, the optimal policy involves a cycle of a fixed number of choices of the schedule with the shorter interval followed by one choice of the schedule with the longer interval. Molecular maximization sometimes results in optimal behavior.     

Constrained least squares estimators of oblique common factors

An expression is given for weighted least squares estimators of oblique common factors, constrained to have the same covariance matrix as the factors they estimate. It is shown that if as in exploratory factor analysis, the common factors are obtained by oblique transformation from the Lawley-Rao basis, the constrained estimators are given by the same transformation. Finally a proof of uniqueness is given.The research reported in this paper was partly supported by Natural Sciences and Engineering Research Council Grant No. A6346.