Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Nonprofessional counselors: Revisiting selection and impact issues

This study examined two issues related to the use of nonprofessional counselors (n = 159) within the context of a diversion program for juvenile offenders. First, the relationship of the nonprofessionals' personality traits and general attitudes to client outcome was examined. No statistically significant correlations were observed. Second, the differential impact of various training and supervision factors was examined in terms of nonprofessional satisfaction, attitudes, and locus of control. Results suggested that training intensity, training content, and supervision setting may influence nonprofessionals' attitudes towards various social groups and their satisfaction with the nonprofessional experience.     

Stability and Change in Type A Components and Cardiovascular Reactivity in Medical Students During Periods of Academic Stress1

This study examined the effects of academic stress upon components of Type A behavior and cardiovascular reactivity. In a longitudinal design, heart rate and blood pressure responses to the Type A Structured Interview (SI) and additional laboratory challenges were measured in medical students at three points during an academic semester. Sessions 1 and 3 were scheduled during vacation periods; Session 2 took place during an intensive examination week. Results indicated that three “stylistic” components of Pattern A derived from the SI—loud and explosive speech, short response latency, and potential for hostility—increased significantly during the exam period. Similar increases achieved marginal significance for another stylistic component, rapid and accelerated speech. By contrast, global Type A assessments did not increase with academic demands. Cardiovascular reactivity was significantly but only moderately stable across the three sessions, showing less consistency than has been reported in previous research. In addition, there was little evidence in this study that cardiovascular reactivity was potentiated by academic stress or by Type A behavior. These results demonstrate the influence of naturalistic environmental factors on overt behavioral components that have recently been suggested as coronary risk factors. Therefore, it is advisable for future experimental and epidemiological research to examine the social and environmental context in which these behaviors occur.     

Stimulus categorization by brain-damaged patients

Patients with localized insult to the right hemisphere, or to either the anterior or the posterior portion of the left hemisphere, as well as neurologically intact controls, evaluated stimuli on a seven-point rating scale for their degree of category membership. The stimuli were taken from one of two continua, one composed of fruit and vegetable items, and the other of items differing in hue and shape. Different subsets of stimuli provided different contexts for the judgments of category membership. The two left-hemisphere groups showed anomalies in categorizing the fruit and vegetable items but not the perceptual items, while the reverse was true for the right-hemisphere patients. Moreover, both left-hemisphere groups demonstrated context effects in their judgments of the representativeness of the fruit and vegetable items, but differed in the way in which they responded to changing contexts. Left posterior patients demonstrated weak category boundaries and even reclassified items. In contrast, patients with left anterior damage showed highly categorical responses and less differentiation of items within a category. All groups showed striking context effects in judgments of perceptual items in terms of changes in representativeness ratings and the location of a category boundary. Alternative interpretations of the results are offered.     

The ABCs of categorical perception

Studies of speech perception first revealed a surprising discontinuity in the way in which stimulus values on a physical continuum are perceived. Data which demonstrate the effect in nonspeech modes have challenged the contention that categorical perception is a hallmark of the speech mode, but the psychophysical models that have been proposed have not resolved the issues raised by empirical findings. This study provides data from judgments of four sensory continua, two visual and two tactual-kinesthetic, which show that the adaptation level for a set of stimuli serves as a category boundary whether stimuli on the continuum differ by linear or logarithmic increments. For all sensory continua studied, discrimination of stimuli belonging to different perceptual categories was more accurate than discrimination of stimuli belonging to the same perceptual category. Moreover, shifts in the adaptation level produced shifts in the location of the category boundary. The concept of Adaptation-level Based Categorization (ABC) provides a unified account of judgmental processes in categorical perception without recourse to post hoc constructs such as implicit anchors or external referents.     

THE PASSIONATE MIND: BRAIN, DREAMS, MEMORY, AND SOCIAL CATEGORIES

Abstract. The intellectualist position held by structuralists does not explain the extremes of emotional reaction to the disruption of social categories. An approach from neuroscience based on the functions of the limbic system in the creation of long-term memory through the role of the hippocampus and REM sleep is proposed to account for the emotive loading of cognitive categories.     

Postnatal development of respiratory and vocal responses during aversive classical conditioning in cats

Respiratory rate, respiration amplitude, and vocal responses were recorded in cats of different ages during classic conditioning. Vocal responses to the conditional stimulus (CS) appeared first in 8-week-old kittens, and became prominent at older ages. An increase in respiration rate occurred after the onset of the CS in cats of all ages. Similarly, the decrease of respiration amplitude was observed at all ages, but only in 8-week-old and older subjects did this response resemble an adult pattern. In 4-week-old kittens the response was characterized by an early and brief peak, suggesting an alpha conditional response (CR). Clear and significant discrimination between a warning and a safety signal was present in both respiratory and vocal responses after the age of 8 weeks.     

Intelligence and age as predictors of motor performance

The Yule-Oseretsky test of motor performance was administered to 10 ‘undifferentiated’ mentally-retarded adults, 10 normal children and 10 normal adults. In accordance with Denny's (1964) 3-group design, the children were matched on mental age with the retardates, the normal adults were matched on chronological age with the retardates, and the children and normal adults were matched on intelligence quotient. The results showed that mental age predicted performance on both fine and gross motor tasks, with the children and retarded adults both obtaining similar relatively-low scores.