Relations between source amnesia and frontal lobe functioning in older adults

A study is reported in which the relations among normal aging, source amnesia, and frontal lobe functioning were explored. Twenty-four older adults (aged 60-84 years) were tested on their ability to remember where they had acquired new factual information; they were also given the Wisconsin Card Sorting Test (WCST), a test of verbal fluency, and other psychometric tests. The degree of source amnesia in this normal sample correlated with age, verbal fluency, and some measures from the WCST. Source amnesia was not related to Performance IQ, however, or to a measure of fact recall. The implications for the relations among aging, memory, and frontal lobe functions are discussed.     

JUDGMENTAL VERSUS STATISTICAL PREDICTION:

Abstract— The relative predictive accuracy of humans and statistical models has long been the subject of controversy even though models have demonstrated superior performance in many studies. We propose that relative performance depends on the amount of contextual information available and whether it is distributed symmetrically to humans and models. Given their different strengths, human and statistical predictions can be profitably combined to improve prediction.     

Offering predictive testing for Huntington disease in a medical genetics clinic: Practical applications

Predictive testing for Huntington disease is presently offered in a select few medical genetics centers in the United States. This is in part due to the labor intensive counseling and psychological testing suggested by the research protocols. We discuss some specific suggestions for establishing programs for Huntington disease predictive testing within pre-existing medical genetics clinics to encourage more centers to offer presymptomatic testing. This will allow more at risk individuals the opportunity to consider predictive testing and cut down the expenses of traveling to the few predictive testing centers that currently exist. The counseling principals will remain similar to those discussed here, even following the identification of the Huntington disease mutation.     

On two arguments for the indeterminacy of personal identity

Both arguments are based on the breakdown of normal criteria of identity in certain science-fictional circumstances. In one case, normal criteria would support the identity of person A with each of two other persons, B and C; and it is argued that, in the imagined circumstances, A=B and A=C have no truth value. In the other, a series or spectrum of cases is tailored to a sorites argument. At one end of the spectrum, persons A and B are such that A=B is clearly true; at the other end, A and B are such that the identity is clearly false. In between, normal criteria of identity leave the truth or falsehood of A=B undecided, and it is argued that in these circumstances A=B has no truth value.These arguments are to be understood counterfactually. My claim is that, so understood, neither establishes its conclusion. The first involves a pair of counterfactual situations that are equally possible or tied. If A=B and A=C have no truth value, a counterfactual conditional with one of them as consequent and an antecedent that is true in circumstances in which either is true should have no truth value. Intuitively, however, any such counterfactual is false. The second argument can be seen to invite an analogous response. If this is right, however, there is an important disanalogy between this and the classical paradox of the heap. If the disanalogy is only apparent, the argument shows at most that the existence of persons can be indeterminate.     

Converging operations on a basic level in event taxonomies

Research on object concepts has identified one level of abstraction as "basic" in cognition and communication. We investigated whether concepts for routine social events have a basic level by replicating the converging operations used to investigate object concepts. In Experiment 1, subjects were presented with event names from a taxonomy and were asked to list the actions comprising the event. Many more actions were listed at the middle than at the highest taxonomic level, without a further increase at the most specific level, paralleling the pattern of superordinate-, basic-, and subordinate-level object concepts. From these action lists, brief stories were composed for each event. In Experiment 2, subjects made pairwise similarity judgments on the stories. The mean similarity of events increased with specificity, as expected. But differentiation of categories (within-category similarity compared to between-category similarity) was highest for super-ordinates, contrary to results with object categories. In Experiment 3, subjects were fastest in recognizing actions as belonging to events named at the basic level. In Experiment 4, subjects predominantly chose basic-level terms to name stories. We conclude that event taxonomies do show basic-level structure, albeit a less sharply defined and less stable structure than in object taxonomies. The benefits and hazards of extending models of object concepts to other entities, such as social events, are discussed.     

Lateralized Changes in Regional Cerebral Blood Flow during Performance of Verbal and Facial Recognition Tasks: Correlations with Performance and “Effort”

Functional neuroimaging has been used to investigate neural substrates of mnemonic processes, and cerebral blood flow (CBF) measures have been sensitive to activation with memory tasks. Studies of memory with two-dimensional¹³³Xenon clearance techniques found that word and face recognition tasks produced contralateral CBF changes in mid-temporal cortical regions. This study replicated the activation paradigm, expanding to the three-dimensional resolution of positron emission tomography (PET). Word and face recognition, and a control baseline task were administered to 19 healthy right-handed volunteers (11 men, 8 women) during successive 10 min PET¹⁵O-water measures of CBF. Quantitative CBF rates were calculated with the arterial input function and the equilibrium model. Redistributions of blood flow were compared across tasks using both absolute and relative (region/whole brain) CBF.Replicating the¹³³Xenon clearance findings, CBF was “appropriately” lateralized during task performance (left–right for words > left–right for faces) in the mid-temporal region. Contrary to predictions, the recognition tasks did not activate expected mesolimbic or prefrontal areas. The task-induced CBF changes also correlated with performance. Bilateral CBF in mid-temporal and parahippocampal gyrus regions of interest correlated with the ability to correctly identify word targets (sensitivity). Left-lateralized CBF in the amygdala and hippocampus correlated with better word sensitivity as well as specificity (ability to correctly reject foils). Complementally, right-lateralized CBF in the parahippocampal gyrus correlated with better face specificity performance. In addition, left-lateralized CBF in the amygdala and right-lateralized CBF in the parahippocampal gyrus and hippocampus correlated with “mental effort” indices (task performance relative to basal ability) for word and face memory tasks, respectively. Thus, whereas this recognition task showed the expected lateralized increase in the mid-temporal region and not in frontal and limbic areas, lateralized activation in some of these areas was associated with better performance. Exploratory analyses on other regions showed lateralized changes in one additional temporal region, the occipital-temporal, and several limbic regions.     

Book reviews

Socializing Epistemology: The Social Dimensions of Knowledge, Frederick F. Schmitt, Ed., 1994. Lanham, MD, Rowman and Littlefield, ix + 315 pp., US$22.95, ISBN: 0847679594

A Dynamic Systems Approach to the Development of Cognition and Action, Esther Thelen & Linda B. Smith. Cambridge, MA, MIT Press, xxii + 376 pp., $50, ISBN 0–262–20095–3 cloth

From Kant to Hilbert: A Source Book in the Foundations of Mathematics, William B. Ewald, Ed., 1996. Oxford, Oxford University Press. xviii+ 1340 pp., £195.00, two volumes, ISBN 0–19–853271–7 (the set)