The $1000 genome: ethical and legal issues in whole genome sequencing of individuals

Progress in gene sequencing could make rapid whole genome sequencing of individuals affordable to millions of persons and useful for many purposes in a future era of genomic medicine. Using the idea of $1000 genome as a focus, this article reviews the main technical, ethical, and legal issues that must be resolved to make mass genotyping of individuals cost-effective and ethically effective. It presents the case for individual ownership of a person's genome and its formation, and shows the implications of that position for rights to informed consent and privacy over sequencing, testing, and disclosing genomic information about identifiable individuals. Legal recognition of a person's right to control his or her genome and the information that it contains is essential for further progress in applying genomic discoveries to human lives.     

Visual field asymmetries and allocation of attention in visual scenes

Single items such as objects, letters or words are often presented in the right or left visual field to examine hemispheric differences in cognitive processing. However, in everyday life, such items appear within a visual context or scene that affects how they are represented and selected for attention. Here we examine processing asymmetries for a visual target within a frame of other elements (scene). We are especially interested in whether the allocation of visual attention affects the asymmetries, and in whether attention-related asymmetries occur in scenes oriented out of alignment with the viewer. In Experiment 1, visual field asymmetries were affected by the validity of a spatial precue in an upright frame. In Experiment 2, the same pattern of asymmetries occurred within frames rotated 90 degrees on the screen. In Experiment 3, additional sources of the spatial asymmetries were explored. We conclude that several left/right processing asymmetries, including some associated with the deployment of spatial attention, can be organized within scenes, in the absence of differential direct access to the two hemispheres.     

Effects of attention and unilateral neglect on auditory stream segregation

Two pairs of experiments studied the effects of attention and of unilateral neglect on auditory streaming. The first pair showed that the build up of auditory streaming in normal participants is greatly reduced or absent when they attend to a competing task in the contralateral ear. It was concluded that the effective build up of streaming depends on attention. The second pair showed that patients with an attentional deficit toward the left side of space (unilateral neglect) show less stream segregation of tone sequences presented to their left than to their right ears. Streaming in their right ears was similar to that for stimuli presented to either ear of healthy and of brain-damaged controls, who showed no across-ear asymmetry. This result is consistent with an effect of attention on streaming, constrains the neural sites involved, and reveals a qualitative difference between the perception of left- and right-sided sounds by neglect patients.     

A Dual Process Model of Attitudes towards Immigration: Person × Residential Area Effects in a National Sample

This research took a person × situation approach to predicting prejudice by looking at how social worldviews interact with real‐world environmental factors to predict how people respond to immigrants within their local area. Taking a Dual Process Motivational approach, we hypothesized that a higher proportion of immigrants in the local community would be associated with negative attitudes toward immigration for respondents high in dangerous world beliefs. Conversely, we hypothesized that living in a highly affluent (as opposed to socioeconomically deprived) community would be associated with negative attitudes toward immigration for respondents high in competitive world beliefs. Both hypotheses were supported using regional information derived from national census data combined with representative survey data from a large telephone sample conducted in New Zealand (N = 6,489). These findings support the proposition that individual differences interact with specific features of the environment to predict people's levels of prejudice in distinct ways.     

Screening for Depression After Stroke: Occupational Therapists' Performance to Protocols

The ability of occupational therapists to enact post-stroke depression screening protocols was considered. The medical notes of 12 patients admitted to an in-patient stroke unit over a 3-month period were consulted to assess timely, appropriate administration, interpretation, and recording of the results of administering the protocols. Post-stroke depression screening by occupational therapists occurred for 83% of patients. Of the screens conducted, all of the patients were administered the correct tool. In 100% of cases screened, the outcome was recorded and in at least 80% clinicians had provided feedback to the patient on the results of the screen.     

Male Veterans' Perceptions of Midlife Career Transition and Life Satisfaction: A Study of Military Men Transitioning to the Teaching Profession

Members of Troops to Teachers (N = 102 male veterans) were surveyed regarding their career transition experiences and life satisfaction. Primary themes related to career transition included preparation for transition, investment vs. sacrifice, and rewards of new career. Primary themes related to life satisfaction included helping and serving others, accomplishment, and contentment vs. struggle.     

A Note on the Speed-Amplitude Function in Movement Control

An experiment is reported that documents the maximum average speed-amplitude relationship across the full range of motion for elbow flexion. Minimum movement time increased as a negative exponential within the movement range up to 94-97% of the maximum range of motion. At this point a discontinuity occurred with movement time increasing at an increasing rate probably due to anatomical and morphological constraints. These results suggest that the maximum average velocity-amplitude boundary to the movement speed-accuracy relationship is curvilinear. Kinematic analysis of the movements as a function of range of motion suggests that a simple pulse-step model of movement control cannot account for the present findings.     

Observational Learning in Pigeons: The effects of Model Proficiency on Observer Performance

Observational learning of a successive visual discrimination problem by pigeons was studied using conspecifics as models performing at proficient or at nonproficient levels. During the observational period, observers were confined without response opportunity and were subsequently trained in the model's discriminative task. Significantly better performance in subsequent learning was found for observers of nonproficient models. In contrast, no significant differences in learning of the visual discrimination task were found between pigeons that observed proficient models and pigeons that had undergone only confinement in the observation apparatus or those trained without prior observation or confinement experience. The apparent paradox of less proficient models producing better learners may be related to the consequences of observing additional negative-stimulus responding per se or to observation of models' behavior changing from less proficient to more proficient with consequent improvement in reinforcement opportunity.     

Development of Bimanual Skill: The Search for Stable Patterns of Coordination

In 2 experiments, dynamic systems theory predictions concerning intrinsic dynamics and variability of bimanual coordination were examined at different developmental stages. In Experiment 1, ten 4-, 6-, 7-, 8-, and 10-year-old children and adults performed unimanual dominant, unimanual nondominant, and bimanual continuous circle drawing. All tasks were performed at the participants' preferred rate, size, and mode of coordination. The 4-, 6-, and 7-year-old children produced larger circles with longer durations than those of the 8- and 10-year-olds and the adults. That finding demonstrates that younger children display different intrinsic dynamics than older children and adults. The 4-, 6-, and 7-year-old children also displayed more variability in bimanual coordination (more time in less stable patterns of coordination, higher standard deviation in relative phase) and produced more transitions between coordination patterns than the 8- and 10-year-olds and the adults. In Experiment 2, the same participants performed bimanual circles at increasing rates. Consistent with predictions of the HKB model (H. Haken, J. A. S. Kelso, & H. Bunz, 1985), the number of transitions decreased as speed increased. Some support was found for the notion that age-related variables of attention and rate contribute to the increased variability in young children's bimanual coordination.