Differential ethanol olfactory experiences affect ethanol ingestion in preweanlings but not in older rats

Preweanling (21 days old) and adult (60-80 days old) rats were exposed to ethanol odor either paired with the early stages of apomorphine-induced toxicosis, paired with the recovery from toxicosis, or unpaired with the induction of distress. Twenty four hours later, ethanol preferences were measured in a spatial olfactory test (ethanol vs lemon odor) or a drinking test (5.6% v/v ethanol vs 0.25% w/v citric acid solutions). During the olfactory test both young and adult rats expressed substantial ethanol odor aversions when previously exposed to this odor paired with toxicosis. However, changes in ethanol intake became apparent only in preweanling subjects. Preweanlings which received the ethanol odor paired with illness drank significantly less of the ethanol solution relative to controls, while subjects experiencing the odor paired with recovery from distress significantly increased their consumption of the ethanol solution. These prior aversive and appetitive olfactory experiences had no effect upon ethanol intake in adult rats. These results implicate both an ontogenetic and a sensorial factor in the regulation of ethanol intake.     

Potentiation and overshadowing in preweanling and adult rats

Four experiments compared the aversion acquired by 18-day-old and 60-day-old rats to a flavor that was either tasted alone or in combination, simultaneously or successively, with another flavor when paired with illness. The purpose was to study temporal variables and theoretical issues pertinent to potentiation and overshadowing while investigating ontogenetic differences in these phenomena. When either the preweanlings or the adults were presented a simultaneous compound flavor (sucrose/coffee) followed by lithium chloride-induced illness, greater sucrose aversions were found than for animals conditioned on sucrose alone--that is, potentiation. Preweanlings demonstrated greater potentiation than did adults, whether the conditioned stimulus-unconditioned stimulus (CS-US) delay was 0 or 1 hr. This potentiation was eliminated by nonreinforced presentations of the alternative CS element. Potentiation was not seen when the two flavors were presented successively as the CS; instead, overshadowing occurred. Tests of configuring by extinction procedures indicated a tendency for these animals to form a configured representation of the simultaneous compound solution. This disposition for configuring tended to be more pronounced for preweanlings than for adults. Ontogenetic differences in response to configuration, CS saliency, and generalization decrement seem consistent with at least one model of potentiation and the ontogenetic differences in potentiation seen in the present experiments.     

Redundancy: a similar principle in independent adaptation techniques

The present study examined the similarities between four auditory adaptation techniques to determine whether the effects were correlated. The four adaptation techniques compared were: Simultaneous Dichotic Loudness Balance technique (SDLB; Hood, 1950), Magnitude Estimated Binaural technique (MEB; Botté, Canévet, & Scharf, 1982), Magnitude Estimated Monaural technique, (MEM; Weiler, Sandman, & Pederson, 1981), and the Monaural Reaction Time technique (RT; Davis & Weiler, 1976). Results did not show significant correlations between the four techniques, except (r = 0.39) between MEB and MEM procedures. This correlation was much less than the reliability of the measures would allow (r = 0.98 and r = 0.99, respectively). Thus, it appears that the different methods either produced different adaptation effects or measured different aspects of auditory adaptation. The normal ear apparently shows several forms of adaptation, which reduces the perceptual strength of a continuing stimulus, in favor of an intermittent, less redundant one.     

Study of neuromotor reaction times under the influence of thyrotropin-releasing hormone

Neuromotor reaction times (simple, choice, and decision) were measured when Thyrotropin-releasing hormone (TRH) was administered intravenously to nine healthy men in a double-blind study. Measurements were made of simple reaction time, choice reaction time, and decision time for each subject at various intervals over a 54-hr. period. Given the observed inherent interaction of the drug with the long time used (54 hr.), most analyses were conducted across separate time epochs. Injected subjects showed inhibition in the normal improvement of simple reaction time (which occurs with practice), and they reduced the time required to make a decision. Choice reaction time, however, remained unchanged across the drug-nondrug experimental conditions.     

Linking person and context in the daily stress process

In this study we combined daily diary data with interview data to investigate individual differences in the impact of stressful daily events on mood. Using a sample of 96 women in an urban community, we examined perceived neighborhood quality and major life events as possibly potentiating the effects of stressful daily events, and we viewed social supports as potentially buffering this daily process. Results confirmed that the presence of chronic ecologic stress (neighborhood perceptions) exacerbated the immediate effects of stressful daily events on mood and also increased the likelihood of enduring effects of daily stressors on next day's mood. Contrary to expectations, previous exposure to major life events decreased the impact of stressful daily events. The availability of social supports, although not buffering the impact of stressful daily events on mood, did mitigate the enduring effects of these events on next day's mood. This study also presents a method for analyzing daily time-series data, while correcting for potential problems of autocorrelated error terms. As such, this study represents a significant advance over previous analytic approaches to time-series data in the study of the stress process.