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41.
42.
Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity 下载免费PDF全文
Boehm J Ehrlich I Hsieh H Malinow R 《Learning & memory (Cold Spring Harbor, N.Y.)》2006,13(5):562-565
The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced synaptic plasticity. 相似文献
43.
There has been growing interest in exploring human performance for situations in which stimuli and/or responses vary along
both horizontal and vertical dimensions. Earlier studies indicated that there is a prevalence of the horizontal dimension
over the vertical dimension in the spatial codes that are used for response selection. We review evidence about spatial coding
for 2-D stimulus—response sets and accounts that have been proposed for explaining how it takes place. Particular attention
is devoted to the relative salience account, which provides the most comprehensive explanation of 2-D spatial coding. We also
evaluate the influence of speed of spatial code formation, number of reference frames, and learning on subjects’ performance
in 2-D tasks. 相似文献
44.
Prado-Alcalá RA Díaz del Guante MA Garín-Aguilar ME Díaz-Trujillo A Quirarte GL McGaugh JL 《Neurobiology of learning and memory》2006,86(2):144-149
The hypothesis that memory is stored through a single stage of consolidation that results in a stable and lasting long-term memory has been challenged by the proposition that reactivation of a memory induces reconsolidation of the memory. The reconsolidation hypothesis is supported by evidence that, under some conditions, post-retrieval treatments affecting amygdala and hippocampus functioning impair subsequent retention performance. We now report that repeated retention testing attenuates the performance impairment induced by post-retrieval reversible inactivation of the amygdala and hippocampus of rats induced by tetrodotoxin. These findings challenge the reconsolidation hypothesis and suggest that the post-retrieval retention performance impairment is best explained as due to temporary retrieval failure. 相似文献
45.
Recognizing individual faces outside one's race poses difficulty, a phenomenon known as the other-race effect. Most researchers agree that this effect results from differential experience with same-race (SR) and other-race (OR) faces. However, the specific processes that develop with visual experience and underlie the other-race effect remain to be clarified. We tested whether the integration of facial features into a whole representation-holistic processing-was larger for SR than OR faces in Caucasians and Asians without life experience with OR faces. For both classes of participants, recognition of the upper half of a composite-face stimulus was more disrupted by the bottom half (the composite-face effect) for SR than OR faces, demonstrating that SR faces are processed more holistically than OR faces. This differential holistic processing for faces of different races, probably a by-product of visual experience, may be a critical factor in the other-race effect. 相似文献
46.
Aguilera A López SR Breitborde NJ Kopelowicz A Zarate R 《Journal of abnormal psychology》2010,119(4):875-885
This study examined whether the sociocultural context moderates the relationship between families' expressed emotion (EE) and clinical outcomes in schizophrenia. In a sample of 60 Mexican American caregivers and their ill relatives, we first assessed whether EE and its indices (criticism, emotional overinvolvement [EOI], and warmth) related to relapse. Second, we extended the analysis of EE and its indices to a longitudinal assessment of symptomatology. Last, we tested whether bidimensional acculturation moderated the relationship between EE (and its indices) and both relapse and symptom trajectory over time. Results indicated that EOI was associated with increased relapse and that criticism was associated with increased symptomatology. Additionally, as patients' Mexican enculturation (Spanish language and media involvement) decreased, EE was increasingly related to relapse. For symptomatology, as patients' U.S. acculturation (English language and media involvement) increased, EE was associated with increased symptoms longitudinally. Our results replicate and extend past research on how culture might shape the way family factors relate to the course of schizophrenia. 相似文献
47.
This article borrowed network analysis tools to discover how the construct formed by the set of all measures of creativity configures itself. To this end, using a variant of the meta-analytical method, a database was compiled simulating 42,381 responses to 974 variables centered on 64 creativity measures. Results, although preliminary, indicate the existence of a core dimension filled with variables that indicate novelty, which is surrounded by the paired dimensions of negative affect and social leadership, and high cognitive performance and positive affect. As for the measurement instruments, it was found that, although tests of divergent thinking, self-reported biographies, and composite scores are the most appropriate tools to gauge creativity itself, both attitude and personality inventories are best for diagnosing the different kinds of creators. 相似文献
48.
Richard S. Balkin Javier Cavazos Jr. Arthur E. Hernandez Roberto Garcia Denise L. Dominguez Alexandra Valarezo 《Journal of Addictions & Offender Counseling》2013,34(1):30-39
Factor analyses were conducted on scores from the Reynolds Adolescent Adjustment Screening Inventory (RAASI; Reynolds, 2001 ) representing at‐risk Latino youth. The 4‐factor model of the RAASI did not exhibit a good fit. However, evidence of generalizability for Latino youth was noted. 相似文献
49.
Hanna Zagefka Dennis Nigbur Roberto Gonzalez Linda Tip 《International journal of psychology》2013,48(1):60-68
A study with British participants (N = 90) tested a potential mediator of the effect of essentialist beliefs about the national ingroup on prejudice against immigrants. Essentialist beliefs were defined as beliefs in genetic determinism, a basic assumption that group membership is “written in the blood” and that the groups’ boundaries and characteristics are determined by genetic and/or biological factors. Essentialist beliefs were expected to play an important role in the formation of prejudice. They were predicted to be associated with a reduction in the perceived possibility of immigrants’ adopting the mainstream culture. Further, it was expected that essentialist beliefs would be positively associated with perceptions of intergroup threat, which in turn would be associated with a stronger demand for immigrants adopting the mainstream culture. Taken together, essentialist beliefs were predicted to be associated with a greater discrepancy between the demand for and perceived feasibility of culture adoption. This discrepancy was hypothesized to mediate the effect of essentialist beliefs on prejudice against immigrants. Structural equation modeling analysis and mediation analysis supported the hypotheses, showing that essentialism attributed to the national ingroup results in people demanding something seemingly impossible from immigrants, and that this situation in which immigrants have little chance of fulfilling majority members’ expectations results in prejudice against them. Thus, results show that perceptions of the ingroup are associated with attitudes to the outgroup, and they outline an explanatory mechanism for the positive correlation between essentialism and prejudice which has been found in previous research. Theoretical and applied implications are discussed. 相似文献
50.
Paola Ricciardelli Cristina Iani Luisa Lugli Antonello Pellicano Roberto Nicoletti 《Cognition & emotion》2013,27(6):1134-1142
Gaze direction and facial expressions are critical components of face processing and have been shown to influence attention deployment. We investigated whether gaze direction (direct vs. averted) combined with a neutral or angry expression modulates the deployment of attentional resources over time. In a Rapid Serial Visual Presentation (RSVP) paradigm participants had to decide the gender of a neutral or an angry target face with direct or averted gaze (T1) and then to judge the orientation of a target picture of a landscape (T2), following the face at different time intervals. Results showed no attentional blink effect (i.e., no deterioration in T2 accuracy) when T1 was an angry face with direct gaze, whereas it was present for angry faces with averted gaze or neutral faces with either averted or direct gaze. These findings are consistent with appraisal theories and are discussed against the background of automatic processing of threat stimuli. 相似文献