AEDs and psychotropic drugs in children with autism and epilepsy

The efficacy of antiepileptic drugs (AEDs) and psychotropic medications in children with autism is limited to the treatment of seizures or to specific behaviors such as irritability, impulsivity, hyperactivity, repetitive behaviors, or aggression. The reliability and value of the available data--to determine the efficacy of these medications in autism--are limited by lack of controlled clinical trials, the small number of subjects, the heterogeneity of the population studied, and the brief duration of most drug trials. Indeed, few controlled clinical trials using AEDs in autism, with or without seizures, have been conducted. Because some AEDs also have a positive effect on mood, the benefits that children with autism sometimes obtain from these medications may not be due to the treatment of the abnormal electrical activity or the seizures per se but to an effect on common neuronal systems responsible for both behavior and epilepsy. The relationship between epilepsy and autism, and specifically the effects that abnormal electrical activity may have on the developing brain, may provide some valuable insights into the type of studies that are needed to help us understand the pathophysiology of autism.     

The effect of context on the processing of type-shifting verbs

Recent research in lexical semantics has suggested that verbs such as begin and enjoy semantically select for a complement that denotes an activity or an event. When no such activity or event is specified in the form of a progressive or infinitival complement, as in John began (to read/reading) the book, the verb is said to "coerce" the NP direct object to shift its role to encompass the activity that begin requires as complement (e.g., writing, reading). Empirical support for this view has been provided by McElree, Traxler, Pickering, Seely, & Jackendoff (2001). In the present study, however, in two self-paced reading experiments, type-shifting effects (taken to be longer reading times engendered by the computation of the coercion process) were not obtained with sentences in isolation (Experiment 1) or with sentences embedded in contexts that specified the nature of the activity performed over the complement NP (Experiment 2). It is argued that type-shifting verbs are similar to non-preferred verbs for given contexts and that type-shifting operations are pragmatic inferences computed over underspecified semantic representations.     

The use of diagrams in analogical problem solving

In four experiments, we examined the impact of perceptual properties on the effectiveness of diagrams in analogical problem solving, using variants of convergence diagrams as source analogues for the radiation problem. Static diagrams representing the initial problematic state (one large line directed at a target) and the final state for a convergence solution (multiple converging lines) were not accessed spontaneously but were often used successfully once a hint to consider the diagram had been provided. The inaccessibility of static diagrams was not alleviated by adding additional diagrams to represent intermediate states (Experiment 1), but spontaneous access was improved by augmenting static diagrams with a verbal statement of the convergence principle (Experiment 3). Spontaneous retrieval and noticing were increased markedly by animating displays representing converging forces and thereby encouraging encoding of the lines as indicating motion toward a target (Experiments 3 and 4). However, neither static nor animated diagrams were effective when the arrows were reversed to imply divergence rather than convergence (Experiment 2). The results indicate that when animation encourages the interpretation of a diagram as a helpful source analogue, it can greatly enhance analogical transfer.     

Processing of global and local information in memory

The experiments reported in this paper were designed to test how global and local information are processed by the memory system. When subjects are required to match a given letter with either a previously presented large capital letter or the small capital letters comprising it, (1) responses to the global level (i.e. the big letter) are faster than responses to the local level (i.e. the small letters), and (2) responses to the latter level only are affected by the consistency between the large and the small letters (Experiment 2), a pattern similar to that obtained in perception (Experiment 1). Such results obtain when subjects are required to attend to only one level with a short ISI between the first and second stimulus, but not when a longer ISI is used (Experiment 5) or when subjects are required to attend to both levels at the same time (Experiments 3 and 4). The results are discussed in the light of a model that postulates a temporal precedence of the global information over the local one at the perceptual level.     

Cross-cultural confirmatory factor analysis of the CES-D in Spanish and Mexican dementia caregivers

The Center for Epidemiologic Studies-Depression Scale (CES-D) is the most frequently used scale for measuring depressive symptomatology in caregiving research. The aim of this study is to test its construct structure and measurement equivalence between caregivers from two Spanish-speaking countries. Face-to-face interviews were carried out with 595 female dementia caregivers from Madrid, Spain, and from Coahuila, Mexico. The structure of the CES-D was analyzed using exploratory and confirmatory factor analysis (EFA and CFA, respectively). Measurement invariance across samples was analyzed comparing a baseline model with a more restrictive model. Significant differences between means were found for 7 items. The results of the EFA clearly supported a four-factor solution. The CFA for the whole sample with the four factors revealed high and statistically significant loading coefficients for all items (except item number 4). When equality constraints were imposed to test for the invariance between countries, the change in chi-square was significant, indicating that complete invariance could not be assumed. Significant between-countries differences were found for three of the four latent factor mean scores. Although the results provide general support for the original four-factor structure, caution should be exercised on reporting comparisons of depression scores between Spanish-speaking countries.